Postoperative Resting Metabolic Rate and Successful Weight Loss After Roux-en-Y Gastric Bypass

Cardia, Lilian; Cleva, Roberto de; Ferreira, Leandro Valle; Gadducci, Alexandre Vieira; Estabile, Priscila; Silva, Paulo Roberto Santos; Greve, Júlia Maria D’Andréa; Santo, Marco Aurélio

doi:10.1007/s11695-023-06498-2

Cited by 3 publications

(1 citation statement)

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“…They also found an inverse association between metabolic adaptation and weight loss after surgery, suggesting that the degree of metabolic adaptation might be one of the factors influencing the extent of weight loss post MBS [53]. In their recent study, Cardia et al [54] evaluated the correlation of resting metabolic rate per kilogram with weight loss at 6 and 36 months post MBS. They found the rate of achieving a successful weight loss was nearly 3 times higher in post-RYGB patients with resting metabolic rate >2 kcal/ kg in comparison with <2 kcal/kg.…”

Section: Glp-1-ras and Metabolic Adaptationmentioning

confidence: 99%

Post metabolic bariatric surgery weight regain: the importance of GLP-1 levels

Çalık Başaran,

Dotan,

Dicker

2024

Int J Obes

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Weight regain and insufficient weight loss are essential problems after metabolic bariatric surgery (MBS) in people living with obesity. Changes in the level of glucagon-like peptide-1 (GLP-1) secreted from the gut after bariatric surgery are one of the underlying mechanisms for successful initial weight loss. Studies and meta-analyses have revealed that postprandial GLP-1 levels increase after the Roux-en-Y gastric bypass and sleeve gastrectomy, but fasting GLP-1 levels do not increase significantly. Some observational studies have shown the relationship between higher postprandial GLP-1 levels and successful weight loss after bariatric surgery. There is growing evidence that GLP-1-receptor agonist (GLP-1-RA) use in patients who regained weight after bariatric surgery has resulted in significant weight loss. In this review, we aimed to summarize the changes in endogenous GLP-1 levels and their association with weight loss after MBS, describe the effects of GLP-1-RA use on weight loss after MBS, and emphasize metabolic adaptations in light of the recent literature. We hypothesized that maintaining higher basal-bolus GLP-1-RA levels may be a promising treatment choice in people with obesity who failed to lose weight after bariatric surgery.

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Section: Glp-1-ras and Metabolic Adaptationmentioning

confidence: 99%