Postoperative short‐term outcomes of minimally invasive versus open esophagectomy for patients with esophageal cancer: An updated systematic review and meta‐analysis

Abstract

Background: We performed a systematic review and meta-analysis to synthesize the available evidence regarding short-term outcomes between minimally invasive esophagectomy (MIE) and open esophagectomy (OE). Methods: Studies were identified by searching databases including PubMed, EMBASE, Web of Science and Cochrane Library up to March 2019 without language restrictions. Results of these searches were filtered according to a set of eligibility criteria and analyzed in line with PRISMA guidelines. Results: There were 33 studies included with a total of 13 269 patients in our review, out of which 4948 cases were of MIE and 8321 cases were of OE. The pooled results suggested that MIE had a better outcome regarding all-cause respiratory complications (RCs) (OR = 0.56, 95% CI = 0.41-0.78, P = <0.001), inhospital duration (SMD = −0.51; 95% CI = −0.78−0.24; P = <0.001), and blood loss (SMD = −1.44; 95% CI = −1.95−0.93; P = <0.001). OE was associated with shorter duration of operation time, while no statistically significant differences were observed regarding other outcomes. Additionally, subgroup analyses were performed for a number of different postoperative events. Conclusions: Our study indicated that MIE had more favorable outcomes than OE from the perspective of short-term outcomes. Further large-scale, multicenter randomized control trials are needed to explore the long-term survival outcomes after MIE versus OE.

Side-to-side esophagogastric anastomosis for minimally invasive Ivor-Lewis esophagectomy: operative technique and short-term outcomes

“…Regarding other post-operative complications, our experience is comparable with those reported in the literature [24,25]. The incidence of chyle leak (12.8%) is higher compared to other studies using either side-to-side or others techniques (Table 6, [26,27]) but comparable with recent reports [28,29] adopting the more stringent definition proposed by ECCG classification.…”

Uniportal VATS Approach in Esophageal Cancer – How to Do It Update

“…A recent meta-analysis comparing MIE (n = 4,948) with open esophagectomy (n = 8,321) revealed fewer pulmonary complications (OR = 0.56; CI = 0.41-0.78; p < 0.001), shorter hospital stays (SMD = −0.51; CI = −0.78 to −0.24; p < 0.001), and less bleeding (SMD: −1.44; CI = −1.95 to −0.93; p < 0.001) with MIE, confirming the outcomes of previous studies (11).…”

TRIP13 Induces Nedaplatin Resistance in Esophageal Squamous Cell Carcinoma by Enhancing Repair of DNA Damage and Inhibiting Apoptosis

“…ESCC is one of the common malignant tumors with high level of incidence and mortality, whose incidence ranked seventh and the mortality ranked sixth in the world in 2018 [ 1 ]. The treatments to ESCC include surgery, chemotherapy, and radiotherapy [ 1 , 9 , 32 , 33 ]. At present, chemotherapy and chemoradiotherapy still plays important roles in adjuvant treatments [ 34 ].…”