Postoperative single-dose interstitial high-dose-rate brachytherapy in therapy-resistant keloids

Hafkamp, C.J.H.; Lapid, Oren; Fajardo, Raquel Dávila; Kar, Annekatrien L. van de; Koedooder, C.; Stalpers, Lukas J.A.; Pieters, Bradley R.

doi:10.1016/j.brachy.2016.12.009

Cited by 16 publications

(15 citation statements)

References 24 publications

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“…Van Leeuwen et al [ 28 ] conducted a systemic review and found that a short-time interval of less than 7 h between keloid excision and irradiation resulted in a lower recurrence rate than that observed with longer time intervals of more than 24 h. Ping Jiang et al [ 14 ] administered the first fraction using brachytherapy within 6 h and observed a very low risk of recurrence. We compressed this interval to less than 2 h, which is in line with previous report [ 12 ]. However, Enhamre and Hammar [ 9 ] found that the treatment success had nothing to do with the time interval between surgical resection and radiotherapy.…”

Section: Discussionsupporting

confidence: 69%

Retrospective study of immediate postoperative electron radiotherapy for therapy-resistant earlobe keloids

Yuan

2019

Arch Dermatol Res

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Keloid resection followed by adjuvant radiotherapy is the most efficacious treatment for keloids. However, for earlobe keloids, an optimal protocol for the total dose and fractions of adjuvant radiation has not yet been established. We retrospectively analyzed the efficacy and safety of immediate three-fraction electron radiotherapy after operation for resistant earlobe keloids. From 2011 to 2017, three-fraction electron radiotherapy with single dose of 5 Gy was given postoperatively to 23 patients with 30 keloids in our hospital. The first fraction of adjuvant radiotherapy was administered within 2 h of surgery, and the other two sessions were completed within the next day or two. Five (16.7%) primary keloids and 25 (83.3%) recurrent keloids were examined in this study. The primary endpoint was the local control rate, which was 86.7% after a median follow-up of 26 months (14–93 months). Secondary endpoints were acute and late procedure-related complications, and no severe complications were observed after combination therapy. Our results suggest that three-fraction electron radiotherapy after excision within 2 days of surgery is a safe and effective protocol for the prevention of earlobe keloid recurrence that can also improve patient compliance and comfort.

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Section: Discussionsupporting

confidence: 69%

Retrospective study of immediate postoperative electron radiotherapy for therapy-resistant earlobe keloids

Yuan

2019

Arch Dermatol Res

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“…It is very important to start treatment as soon as possible after surgery, if possible 90 min after surgery, and always before 24 h, to avoid the regrowth of the keloid. Different fractionations have been used and there is not a standard recommended schedule [68][69][70][71][72][73][74][75][76][77]. A systematic review of published papers [78] showed that the mean total radiation dose for studies investigating external radiation and HDR brachytherapy was the same (external, 13.5 ± 3.3 Gy; HDR, 13.7 ± 2.6 Gy) and higher when using LDR brachytherapy (19.3 ± 1.2 Gy).…”

Section: Keloidsmentioning

confidence: 99%

GEC-ESTRO ACROP recommendations in skin brachytherapy

Guinot

Rembielak

Pérez‐Calatayud

et al. 2018

Radiotherapy and Oncology

135

134

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“…34 Several successful radiation therapy strategies exist for the postoperative treatment of keloids, 31,33 including externalbeam radiation therapy (using superficial xrays 35,36 or electrons 34,37 ) and brachytherapy. [38][39][40] Local control for resected keloids treated with radiation therapy may be dose-dependent, with higher radiation doses (e.g., biologically equivalent dose 2 > 60, such as 2,000 cGy in five fractions) resulting in lower rates of local recurrence than lower radiation doses. 41,42 Potential complications of radiation therapy are divided into acute (occurring during or shortly after completion of radiation) and late (developing months or years following completion of radiation) and are dose-dependent and generally mild.…”

Section: Radiation Therapymentioning

confidence: 99%

Management of Facial Scars

et al. 2019

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Scarring is a natural process of healing after damage to the skin that extends to the reticular dermis. While some scars may be socially acceptable, even admirable, scars of the face can be viewed as disfiguring or ugly. Minimizing the appearance of facial scars and optimizing their cosmetic outcome ideally begin before surgery or, in the cause of trauma, at the initial reconstruction. Even when there has been poor initial healing, a scar's appearance can be improved. Herein, we review conservative, medical, and surgical therapies to improve the appearance of facial scars.

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Postoperative single-dose interstitial high-dose-rate brachytherapy in therapy-resistant keloids

Cited by 16 publications

References 24 publications

Retrospective study of immediate postoperative electron radiotherapy for therapy-resistant earlobe keloids

Retrospective study of immediate postoperative electron radiotherapy for therapy-resistant earlobe keloids

GEC-ESTRO ACROP recommendations in skin brachytherapy

Management of Facial Scars

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