Postoperative Thecal Sac Compression Induced by Hydrogel Dural Sealant after Spinal Schwannoma Removal

Han, Hee-Jeong; Jeong, Ju Ho; Kim, Jin Wook; Seung, Won-Bae

doi:10.13004/kjnt.2020.16.e10

Cited by 5 publications

(9 citation statements)

References 20 publications

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“…One main disadvantage is the extensive swelling behaviors of PEG‐based hydrogels, which can significantly deteriorate its mechanical properties and limit its uses in circumstances that are sensitive to the hydrogel shape and volume, such as in potential neural compression by a spinal sealant. [ 445 ] Efforts have been made to achieve nonswellable hydrogels by introducing thermosensitive moieties into the backbone ( Figure ), [ 31,118,446 ] or more generally, by controlling the polymer–solvent interaction parameter (χ), [ 447 ] but how these will affect their tissue adhesion remains to be determined. In a recent study, Hayashi and colleagues demonstrated such low swellable PEG hydrogels to be useful for the application as artificial vitreous bodies.…”

Section: Polymer Precursorsmentioning

confidence: 99%

Covalently Crosslinked Hydrogels via Step‐Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact

2021

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Hydrogels are an important class of biomaterials with the unique property of high‐water content in a crosslinked polymer network. In particular, chemically crosslinked hydrogels have made a great clinical impact in past years because of their desirable mechanical properties and tunability of structural and chemical properties. Various polymers and step‐growth crosslinking chemistries are harnessed for fabricating such covalently crosslinked hydrogels for translational research. However, selecting appropriate crosslinking chemistries and polymers for the intended clinical application is time‐consuming and challenging. It requires the integration of polymer chemistry knowledge with thoughtful crosslinking reaction design. This task becomes even more challenging when other factors such as the biological mechanisms of the pathology, practical administration routes, and regulatory requirements add additional constraints. In this review, key features of crosslinking chemistries and polymers commonly used for preparing translatable hydrogels are outlined and their performance in biological systems is summarized. The examples of effective polymer/crosslinking chemistry combinations that have yielded clinically approved hydrogel products are specifically highlighted. These hydrogel design parameters in the context of the regulatory process and clinical translation barriers, providing a guideline for the rational selection of polymer/crosslinking chemistry combinations to construct hydrogels with high translational potential are further considered.

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Section: Polymer Precursorsmentioning

confidence: 99%

Covalently Crosslinked Hydrogels via Step‐Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact

2021

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“…The reduced swelling rate of the bi‐layer patch may be due to the addition of MBG and the extension of the exposure time when printing the first layer of patch. The swelling rate of the bi‐layer patch was lower than that of DuraSeal (50%), [ 53 ] and the grid structure did not deform after swelling (Figure S3E, Supporting Information). According to previous research, [ 54 ] the incorporation of MBG nanoparticles reduces the degradation rate of hydrogels due to the enhanced cross‐linking of MBG.…”

Section: Resultsmentioning

confidence: 99%

A Novel 3D‐Printed Bi‐Layer Cranial‐Brain Patch Promotes Brain Injury Repair and Bone Tissue Regeneration

Zhou,

Liu,

Zhang

et al. 2024

Adv Funct Materials

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Traumatic brain injury (TBI), recognized as the world's most serious public health problem, currently lacks effective treatment options. The development of the patch has great clinical significance whether it is used as a skull implant material or TBI repair. In response to this critical health challenge, a novel 3D‐printed bi‐layer cranial‐brain patch (SMB6) with dual functionality, addressing both TBI repair and skull regeneration, is developed. In the first layer, the incorporation of high concentrations of mesoporous bioactive glass nanoparticles establishes a microenvironment for bone regeneration. Meanwhile, the second layer, comprised of methacrylated silk fibroin hydrogel, provides essential mechanical support for nanocell membrane vesicles loaded with macrophage colony‐stimulating factor and interleukin‐6. This innovative design aims to interrupt the cascade of secondary brain injury. In experimental models of TBI, SMB6 demonstrates remarkable efficacy in inhibiting brain edema, exerting therapeutic effects on blood vessels, nerves, and inflammation. Additionally, promising outcomes are observed in promoting bone regeneration in skull defect models. This work not only introduces a potential therapeutic patch for TBI‐related diseases but also provides novel insights for the clinical translation of cranial patches.

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“…The healing pe-riod of surgical areas such as muscles, skin, and bones may be prolonged due to CSF leakage. This can potentially lead to complications such as meningitis, nausea, vomiting, vertigo, tinnitus, postural headache, and fistula formation 3,5,13) . Therefore, preventing CSF leakage is very important.…”

Section: Discussionmentioning

confidence: 99%

“…Cerebrospinal fluid (CSF) leakage is a rare complication that can occur in spinal surgery. Postoperative CSF leakage can induce delayed healing, wound infections, and intracranial hypotension, which causes neurological symptoms such as postural headache, vomiting, and dizziness 3,5,[11][12][13] . Repair of CSF leakage due to dural defects that may occur during surgery is very important and Dural Sealant System can be used in this case.…”

Section: Introductionmentioning

confidence: 99%

Postoperative Thoracic Cord Compression Induced by a Dural Sealant System (DuraSeal®): A Case Report and Literature Review

Jang,

Sheen,

Han

et al. 2024

Nerve

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Cerebrospinal fluid (CSF) leakage is a rare complication that can occur due to dural defects during spinal surgery, hindering the improvement of the surgical site and increasing the possibility of infection. DuraSeal® is a dural sealing adhesive that prevents CSF leakage and is used as an adjunct to enable the watertight repair of dural defects when the dura is damaged during spinal surgery. In the present case, DuraSeal® was applied to repair a dural defect in the surgical area after thoracic spine surgery, and no neurological problems occurred immediately after surgery. However, a day later, the patient’s paraparesis worsened; therefore, reoperation was performed and the symptoms improved.

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Postoperative Thecal Sac Compression Induced by Hydrogel Dural Sealant after Spinal Schwannoma Removal

Cited by 5 publications

References 20 publications

Covalently Crosslinked Hydrogels via Step‐Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact

Covalently Crosslinked Hydrogels via Step‐Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact

A Novel 3D‐Printed Bi‐Layer Cranial‐Brain Patch Promotes Brain Injury Repair and Bone Tissue Regeneration

Postoperative Thoracic Cord Compression Induced by a Dural Sealant System (DuraSeal®): A Case Report and Literature Review

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