Postoperative troponin release is associated with major adverse cardiovascular events in the first year after noncardiac surgery

Immediate postoperative high-sensitivity troponin T concentrations and long-term patient-reported health-related quality of life

“…The current study is nested within an observational cohort registry of patients aged at least 60 years undergoing intermediate-to-high risk noncardiac surgery at the Erasmus University Medical Centre, Rotterdam, the Netherlands between July 2012 and July 2015, who have been described previously. 1,11,12 This registry was reviewed by the Medical Ethical Committee of Erasmus University, Rotterdam, who approved the noninterventional character of the study (MEC-2013-397). The study was conducted in compliance with the Helsinki declaration 13 and strengthening the reporting of observational studies in epidemiology criteria 14 for observational studies.…”

“…For analysis, troponin levels were divided into four categories, as previously published. 1,11,12 The first category (<14 ng l À1 ) is considered normal, based on the manufacturer's 99th percentile of a normal population. 15 The second (14 to 49 ng l À1 ) was based on the 0.03 ng ml À1 threshold of the fourth-generation assay's abnormal elevations, which is equivalent to 50 ng l À1 of the fifth assay.…”

“…A substantial number of patients undergoing intermediate to high-risk noncardiac surgery develop peri-operative myocardial injury, [1][2][3] detected by an elevated troponin level. 4 Postsurgical troponin concentrations have been shown to be independently associated with early and late mortality and also major adverse cardiovascular events (MACE).…”

“…4 Postsurgical troponin concentrations have been shown to be independently associated with early and late mortality and also major adverse cardiovascular events (MACE). 1,2,5,6 Physical wellbeing following surgery is traditionally evaluated by using clinical measures such as surgical outcome and mortality, but patient-reported outcome measures (PROMs) are increasingly being regarded as important. 7 Health-related quality of life (HRQoL) is such a PROM, measuring the impact of disease on physical and mental health.…”

Myocardial injury after non-cardiac surgery: current state of the problem and unresolved issues

“…Определение вч-сТнТ позволяет оценить не только краткосрочный, но и отдалённый прогноз, как показали результаты крупного регистрового исследования. У пациентов старше 60 лет умеренного или высокого риска уровень вч-сТнТ ≥14 нг/л был ассоциирован с 2-10-кратным увеличением ОР больших сердечно-сосудистых событий в течение 1 года после операции [27].…”