Postoperative venous thromboembolism and brain tumors: part III. Biochemical profile

Abstract

The plasminogen activator activity of 31 human brain tumor samples was assessed and the results correlated with clinical parameters and the postoperative occurrence of venous thrombosis. A significant negative correlation was found between plasminogen activator activity and venous thrombosis (P = 0.02), while positive correlations were observed between plasminogen activator activity and peritumoral brain edema (P = 0.03) and alpha2 antiplasmin measured in the systemic circulation (P = 0.01). Tissue plasminogen activator was found in higher concentrations in meningioma tissue but did not correlate significantly with the occurrence of venous thrombosis. The results of this study suggest a local enzymatic degradation effect of plasminogen activator on thrombogenic substances present in the brain tumor and/or its environment.

Effect of dalteparin and radiation on survival and thromboembolic events in glioblastoma multiforme: a phase II ECOG trial

“…using I-fibrinogen scanning, demonstrated DVT's in 60% of GBM patients; the presence of TEE did not correlate with ambulatory status, time of surgery, length of operation, or occurrence in a paretic limb. Sawaya and Highsmith (1992) [13] have suggested malignant brain tumors release a factor responsible for this predisposition to coagulopathy. Previous work suggesting increased platelet adhesiveness in malignant brain tumors is consistent with this supposition [14,16].…”

“…Additionally, there was recognized at the onset of clinical trial design that patients with GBM were highly predisposed to thromboembolic phenomena [10][11][12][13][14][15][16][17][18][19][20]. Thus, it was further hypothesized that the administration of dalteparin, a LMWH, might provide prophylaxis for TEE.…”

Complications of the Middle Cranial Fossa Approach for Acoustic Neuroma Removal

“…It can be lowered to 6% by application of heparin [29] . Without prophylaxis, such patients are at risk of sustaining a PE of 1.4%-5% [28,30,31] . Exact guidelines exist for prophylaxis of DVT.…”

Supportive Therapie und Palliativmedizin bei Patienten mit malignen Gliomen

“…Die Häufigkeit thromboembolischer Komplikationen liegt etwa zwischen 15-40 % [39,40]. Vor allem das perioperative Risiko ist hier herauszustreichen.…”