“…The papers located indicate a wide variety of underlying pathologies as the cause for surgery including ankle arthritis, 17,18 and trauma, 15 or mixed populations including inflammatory disease (OA). 16,19,20 Whilst age and other demographics are reported well in the papers, there is little information regarding comorbidities that may be important in terms of post-operative recovery and complications, for example diabetes. Each of the studies had small numbers of participants (highest n ¼ 60), with only one study using a power calculation to identify their sample size required.…”