Postpandemic Influenza Mortality of Venovenous Extracorporeal Membrane Oxygenation–Treated Patients in Reunion Island: A Retrospective Single Center Study

Vandroux, David; Kerambrun, Hugo; Ferdynus, Cyril; Allou, Nicolas; Allyn, Jérôme; Gaüzère, Bernard-Alex; Martinet, Olivier; Jabot, Julien

doi:10.1053/j.jvca.2019.12.043

Cited by 4 publications

(5 citation statements)

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“…Nine studies reported the economic burden of influenza-associated hospital admission, from hospital and ICU length of stay (LOS) and related resource use (Table 5 ) [ 26 , 29 , 30 , 34 , 35 , 37 , 38 , 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…Two studies reported increased median length of hospitalization stay with increasing age [ 26 , 34 ]. Additionally, the median length of mechanical ventilation and ICU stay were reported at 22 and 14 days, respectively, while mean length was 15 and 13 days [ 37 , 47 ]. However, these studies were limited to France, Spain, and the US, and length of mechanical ventilation and ICU stay were not stratified by age, so the impact of increasing age may not apply to these outcomes.…”

Section: Resultsmentioning

confidence: 99%

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Understanding the Global Burden of Influenza in Adults Aged 18–64 years: A Systematic Literature Review from 2012 to 2022

et al. 2023

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Introduction Adults aged 18–64 years comprise most of the working population, meaning that influenza infection can be disruptive, causing prolonged absence from the workplace, and reduced productivity and the ability to care for dependents. Influenza vaccine uptake is relatively low, even among the older adults in this population (i.e., aged 50–64 years), reflecting a lack of perceived need for vaccination. This systematic literature review (SLR) aimed to characterize the global burden of influenza in the 18–64 years population. Methods An electronic database search was conducted and supplemented with conference and gray literature searches. Eligible studies described at least one of clinical, humanistic, or economic outcomes in adults aged 18–64 years and conducted across several global regions. Included studies were published in English, between January 1, 2012, and September 20, 2022. Results A total of 40 publications were included, with clinical, humanistic, and economic outcomes reported in 39, 5, and 15, respectively. Risk of influenza-associated clinical outcomes were reported to increase with age among the 18–64 years population, including hospitalizations (Yamana et al. in Intern Med 60:3401–3408, 2021; Derqui et al. in Influenza Other Respir Viruses 16:862–872, 2022; Fuller et al. in Influenza Other Respir Viruses 16:265–275, 2022; Ortiz et al. in Crit Care Med 42:2325–2332, 2014; Yandrapalli et al. in Ann Transl Med 6:318, 2018; Zimmerman et al. in Influenza Other Respir Viruses 16:1133–1140, 2022). ICU admissions, mortality, ER/outpatient visits, and use of mechanical ventilation were recorded. Adults aged 18–64 years with underlying comorbidities were at higher risk of influenza-related hospitalizations, ICU admission, and mortality than otherwise healthy individuals. Length of hospital stay increased with age, although a lack of stratification across other economic outcomes prevented identification of further trends across age groups. Conclusions High levels of hospitalization and outpatient visits demonstrated a clinical influenza-associated burden on patients and healthcare systems, which is exacerbated by comorbidities. Considering the size and breadth of the general population aged 18–64 years, the limited humanistic and economic findings of this SLR likely reflect an underreported burden. Greater investigation into indirect costs and prolonged absenteeism associated with influenza infection is required to fully understand the economic burden in this population. Supplementary Information The online version contains supplementary material available at 10.1007/s12325-023-02610-1.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Understanding the Global Burden of Influenza in Adults Aged 18–64 years: A Systematic Literature Review from 2012 to 2022

et al. 2023

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“…Despite the higher severity of illness in the H1N1 patients, we did not find a difference in survival according to viral subtype. Studies evaluating the use of ECMO for other viral etiologies of ARDS continue to emerge (33)(34)(35)(36)(37)(38). Since the novel coronavirus disease 2019 pandemic, investigators have reported successful ECMO support with similar survival to hospital discharge, even when directly compared with influenza cohorts (36,37).…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal Membrane Oxygenation Support for Influenza A: Retrospective Review of the Extracorporeal Life Support Organization Registry Comparing H1N1 With Other Subtypes

OʼNeil

Lin

et al. 2021

Critical Care Explorations

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“…The medical infrastructure in Reunion Island meets European standards (P3 laboratories, 16 extracorporeal membrane oxygenation machines, coronary angiography, surgeons trained to perform all types of surgeries, among others). [ 4 ] When Mayotte Hospital became overwhelmed with cases of SARS-CoV-2 pneumonia, several patients were transferred to Félix Guyon University Hospital in Reunion Island, in a context of solidarity among islands of the Indian Ocean region. All patients had to be evacuated by air due to the emergency situation.…”

Section: Introductionmentioning

confidence: 99%

“…In February 2021, the only hospital of the island, Mayotte Hospital, [1] was overwhelmed by the explosion in the number of cases, as it is equipped with only 16 intensive care unit (ICU) beds for a population of 270,000 inhabitants. The medical infrastructure in Reunion Island meets European standards (P3 laboratories, 16 extracorporeal membrane oxygenation machines, coronary angiography, surgeons trained to perform all types of surgeries, among others) [4] . When Mayotte Hospital became overwhelmed with cases of SARS-CoV-2 pneumonia, several patients were transferred to Félix Guyon University Hospital in Reunion Island, in a context of solidarity among islands of the Indian Ocean region.…”

Section: Introductionmentioning

confidence: 99%

Emergency air evacuation of patients with acute respiratory failure due to SARS-CoV-2 from Mayotte to Reunion Island

Berguigua

Iché²,

Roché³

et al. 2021

Medicine

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In February 2021, an explosion of cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia overwhelmed the only hospital in Mayotte. To report a case series of patients with acute respiratory failure (ARF) due to SARS-CoV-2 who were evacuated by air from Mayotte to Reunion Island. This retrospective observational study evaluated all consecutive patients with ARF due to SARS-CoV-2 who were evacuated by air from Mayotte Hospital to the intensive care unit (ICU) of Félix Guyon University Hospital in Reunion Island between February 2, and March 5, 2021. A total of 43 patients with SARS-CoV-2 pneumonia were evacuated by air, for a total flight time of 2 hours and a total travel time of 6 hours. Of these, 38 patients (88.4%) with a median age of 55 (46–65) years presented with ARF and were hospitalized in our ICU. Fifteen patients were screened for the SARS-CoV-2 501Y.V2 variant, all of whom tested positive. Thirteen patients (34.2%) developed an episode of severe hypoxemia during air transport, and the median paO 2 /FiO 2 ratio was lower on ICU admission (140 [102–192] mmHg) than on departure (165 [150–200], P = .022). Factors associated with severe hypoxemia during air transport was lack of treatment with curare ( P = .012) and lack of invasive mechanical ventilation ( P = .003). Nine patients (23.7%) received veno-venous extracorporeal membrane oxygenation support in our ICU. Seven deaths (18.4%) occurred in hospital. Emergency air evacuation of patients with ARF due to SARS-CoV-2 was associated with severe hypoxemia but remained feasible. In cases of ARF due to SARS-CoV-2 requiring emergency air evacuation, sedated patients receiving invasive mechanical ventilation and curare should be prioritized over nonintubated patients. It is noteworthy that patients with SARS-CoV-2 pneumonia related to the 501Y.V2 variant were very severe despite their young age.

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Postpandemic Influenza Mortality of Venovenous Extracorporeal Membrane Oxygenation–Treated Patients in Reunion Island: A Retrospective Single Center Study

Cited by 4 publications

References 15 publications

Understanding the Global Burden of Influenza in Adults Aged 18–64 years: A Systematic Literature Review from 2012 to 2022

Understanding the Global Burden of Influenza in Adults Aged 18–64 years: A Systematic Literature Review from 2012 to 2022

Extracorporeal Membrane Oxygenation Support for Influenza A: Retrospective Review of the Extracorporeal Life Support Organization Registry Comparing H1N1 With Other Subtypes

Emergency air evacuation of patients with acute respiratory failure due to SARS-CoV-2 from Mayotte to Reunion Island

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