Postpartum depression, a direct and mediating risk factor for preschool wheeze in girls

Alton, Megan E.; Zeng, Yiye; Tough, Suzanne; Mandhane, Piushkumar J.; Kozyrskyj, Anita L.

doi:10.1002/ppul.23308

Cited by 18 publications

(22 citation statements)

References 57 publications

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“…When postnatal exposures were considered, maternal psychological distress, as well IPV exposure, were strongly associated with the child experiencing at least one episode of wheezing during the 24‐month period, as well as recurrent wheeze episodes. These results strengthen the findings of several studies reporting on the relationship between maternal psychosocial risk factors and childhood wheeze and asthma, and extend the association into a LMIC context.…”

Section: Discussionsupporting

confidence: 89%

Associations between maternal mental health and early child wheezing in a South African birth cohort

MacGinty

Lesosky

Barnett

et al. 2018

Pediatric Pulmonology

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BackgroundWheezing in early childhood is common and has been identified in high‐income countries (HIC) as associated with maternal antenatal or postnatal psychosocial risk factors. However, the association between maternal mental health and childhood wheezing has not been well studied in low and middle‐income countries (LMIC), such as South Africa.MethodsA total of 1137 pregnant women over 18 year old, between 20 and 28 weeks’ gestation, and attending either of two catchment area clinics were enrolled in a South African parent study, the Drakenstein Child Health Study (DCHS). Psychosocial risk factors including maternal depression, psychological distress, early adversity, and intimate partner violence (IPV), were measured antenatally and postnatally by validated questionnaires. Two outcomes were evaluated: Presence of wheeze (at least one episode of child wheeze during the first 2 years of life); and recurrent wheeze (two or more episodes of wheezing in a 12‐month period). Logistic regression was used to investigate the association between antenatal or postnatal psychosocial risk factors and child wheeze, adjusting for clinical and socio‐demographic covariates.ResultsPostnatal psychological distress and IPV were associated with both presence of wheeze (adjusted OR = 2.09, 95%CI: 1.16‐3.77 and 1.63, 95%CI: 1.13‐2.34, respectively), and recurrent child wheeze (adjusted OR = 2.26, 95%CI: 1.06‐4.81 and 2.20, 95%CI: 1.35‐3.61, respectively).ConclusionMaternal postnatal psychological distress and IPV were associated with wheezing in early childhood. Thus, screening and treatment programs to address maternal psychosocial risk factors may be potential strategies to reduce the burden of childhood wheeze in LMICs.

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Section: Discussionsupporting

confidence: 89%

Associations between maternal mental health and early child wheezing in a South African birth cohort

MacGinty

Lesosky

Barnett

et al. 2018

Pediatric Pulmonology

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“…New evidence from large, general population cohorts has extended these initial associations in several ways. Second, postpartum depression was found to mediate the association between prenatal distress and preschool wheeze in girls, but it also had a direct association with wheeze [17]. Second, postpartum depression was found to mediate the association between prenatal distress and preschool wheeze in girls, but it also had a direct association with wheeze [17].…”

Section: Introductionmentioning

confidence: 87%

“…First, maternal distress or anxiety during pregnancy was observed to be associated with preschool wheeze [15] but also with school-age asthma [16]. Second, postpartum depression was found to mediate the association between prenatal distress and preschool wheeze in girls, but it also had a direct association with wheeze [17]. Lastly, only maternal distress that persisted beyond the postnatal period has shown to increase the risk of asthma at 7 years of age [18], and Giallo et al [19] found this association to be independent of prenatal distress.…”

Section: Introductionmentioning

confidence: 99%

Associations between postpartum depressive symptoms and childhood asthma diminish with child age

Kozyrskyj

Létourneau

Kang

et al. 2016

Clin Experimental Allergy

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“…Modern living conditions include changing hygiene and exposure to air pollution, but also depression and stress. Alton et al investigated 791 women and their children at 3 years of age, to identify whether postpartum depression is a risk factor for preschool wheeze. Postpartum depression was present in about 8% of the women and it increased the risk of wheezing in girls but not boys.…”

Section: Asthmamentioning

confidence: 99%

Pediatric pulmonology year in review 2016: Part 2

et al. 2017

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Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

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Postpartum depression, a direct and mediating risk factor for preschool wheeze in girls

Cited by 18 publications

References 57 publications

Associations between maternal mental health and early child wheezing in a South African birth cohort

Associations between maternal mental health and early child wheezing in a South African birth cohort

Associations between postpartum depressive symptoms and childhood asthma diminish with child age

Pediatric pulmonology year in review 2016: Part 2

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