Postpartum Depression: A Review

Patel, Milapkumar; Bailey, Rahn Kennedy; Jabeen, Shagufta; Ali, Shahid; Barker, Narviar C.; Osiezagha, Kenneth

doi:10.1353/hpu.2012.0037

Cited by 128 publications

(111 citation statements)

References 40 publications

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“…Clinical manifestations of postpartum depression include inability to sleep or sleeping much, mood swings, change in appetite, fear of harming, extreme concern and worry about the baby, sadness or excessive crying, feeling of doubt, guilt and helplessness, difficulty concentrating and remembering, loss of interest in hobbies and usual activities, and recurrent thoughts of death, which may include suicidal ideation (Patel et al, 2012). Many experts in the field consider the extension of postpartum depression onset symptoms to 12 months after delivery .…”

Section: Introductionmentioning

confidence: 99%

Magnitude and risk factors for postpartum symptoms: A literature review

Norhayati

Hussain

Asrenee

et al. 2015

Journal of Affective Disorders

644

510

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The current prevalence of postpartum depression is much higher than that previously reported, and similar risk factors are documented. A culturally sensitive cut-off score with adequate psychometric properties of the screening instruments should be available. In future studies, examining the physical, biological, and cultural factors in qualitative studies and in those with adequate methodological qualities is recommended.

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Section: Introductionmentioning

confidence: 99%

Magnitude and risk factors for postpartum symptoms: A literature review

Norhayati

Hussain

Asrenee

et al. 2015

Journal of Affective Disorders

644

510

View full text Add to dashboard Cite

show abstract

“…The normal cognitive and psychological development of an adolescent plays an important part in adapting to the maternal role, influencing both the mother's integration into the role and the infant's development (Furtenburg, Brook-Gunn, & Morgan, 1987;Patel, Bailey, Jabeen, Ali, Barker, & Osiezagha, 2012). However, motherhood has been considered as a developmental task of adulthood because of the intrapersonal transition period.…”

Section: Adolescent Motherhood Developmentmentioning

confidence: 99%

Early Preterm Infant Feeding Behaviors in Adolescent and Adult Mothers

Kanhadilok¹,

Brown²

2016

Asian Journal for Public Opinion Research

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“…Approximately 13% of women experience PPD within 14 weeks after giving birth [19], and 19% of women experience a depressive episode during pregnancy or during the first 3 months postpartum [20]. PPD has both immediate and long-term effects on a mother's mental health, as well as negative effects on the development of their children [21][22][23]. Women suffering from PPD display a disturbed mother-infant relationship, decreased responsiveness to the demands of parenting, mood disorders, symptoms of anxiety and confusion [24,25].…”

Section: Introductionmentioning

confidence: 99%

Maternal alterations in the proteome of the medial prefrontal cortex in rat

Völgyi

Udvari²,

Szabó³

et al. 2017

Journal of Proteomics

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Proteomic differences between rat dams and control mothers deprived of their pups immediately after delivery were investigated in the medial prefrontal cortex (mPFC).A 2-D DIGE minimal dye technique combined with LC-MS/MS identified 32 different proteins that showed significant changes in expression in the mPFC, of which, 25were upregulated and 7 were downregulated in dams. The identity of one significantly increased protein, the small heat-shock protein alpha-crystallin B chain (Cryab), was confirmed via Western blot analysis. Alpha-crystallin B chain was distributed in scattered cells in the mPFC, as demonstrated by immunohistochemistry. Furthermore, it was found to be localized in parvalbumin-containing neurons using double labeling. The elevation of its mRNA level in rat dams was also demonstrated via RT-PCR.The functional classification of the altered proteins was conducted using the UniProt and Gene Ontology protein databases. The identified proteins predominantly participate in synaptic transport and plasticity, neuron development, oxidative stress and apoptosis, and cytoskeleton organization. A common regulator and target analysis of these proteins determined using the Elsevier Pathway Studio Platform suggests that protein level changes associated with pup nursing are driven by growth factors and cytokines, while the MAP kinase pathway was identified as a common target. A high proportion of the proteins that were found to be altered in the mPFC are associated with depression. Biological significanceThe behavior and emotional state of females change robustly when they become mothers. The brain, which governs these changes, may also undergo molecular alterations in mothers. As no proteomics approaches have been applied regarding maternal changes in the brain, we addressed this issue in the mPFC as this brain area is the uppermost cortical center Alpha-crystallin B chain, a protein confirmed to be increased during maternal behaviors, was selectively found in parvalbumin cells, which, as fast-spiking interneurons, are associated with depression. The function of alpha-crystallin B chain should be further investigated to establish whether it can be used to identify drug targets for future drug development.

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Postpartum Depression: A Review

Cited by 128 publications

References 40 publications

Magnitude and risk factors for postpartum symptoms: A literature review

Magnitude and risk factors for postpartum symptoms: A literature review

Early Preterm Infant Feeding Behaviors in Adolescent and Adult Mothers

Maternal alterations in the proteome of the medial prefrontal cortex in rat

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