Postpartum depression in rats causes poor maternal care and neurochemical alterations on dams and long-lasting impairment in sociability on the offspring

Zaccarelli-Magalhães, Julia; Abreu, Gabriel; Fukushima, André Rinaldi; Pantaleon, Lorena P; Ribeiro, Beatriz B; Munhoz, Camila; Manes, Marianna; Lima, Mayara A de; Miglioli, Júlia; Flório, Jorge Camilo; Lebrun, Ivo; Waziry, Paula A. Faria; Fonseca, Tatiana L.; Bocco, Bárbara M L C; Bianco, Antonio C.; Ricci, Esther Lopes

doi:10.1016/j.bbr.2022.114082

Cited by 11 publications

(4 citation statements)

References 98 publications

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“…Results relative to the social interaction de cit observed in Al, Cd and the co-exposure groups are in tandem with previous reports related to Al and Cd on their ability to reduce the social interaction index of animals [48,49]. The variation in social interaction index in postpartum mice may have occurred with respect to possible alteration of the brain neurochemistry by the metals and in thyroid homeostasis which normally remains so during lactation [50]. Though there are evidence-based research on existence of postpartum social withdrawal in animals [51,52,53] the fact that these reductions were further aggravated by the exposure of these metals with Cd showing more negative impact is re ective of the potential in uence of the metals in postpartum maternal adjustments.…”

Section: Discussionsupporting

confidence: 86%

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

Biol Trace Elem Res

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Most research has not been done on the possible relationship between pregnant women' cross-metal exposures and postpartum neuroendocrine functions. The purpose of this study was to look into how coexposure to aluminium chloride (AlCl3) and cadmium chloride (CdCl2) affected the neuroendocrine and neurometabolic changes in postpartum mice A total of 24 adult pregnant female mice were used for the study. Group 1 comprised pregnant mice (n = 6) treated with AlCl 3 (10mg/kg), group 2; CdCl 2 (1.5mg/kg), group 3 a combination of AlCl 3 (10 mg/kg) and CdCl 2 (1.5 mg/kg) and group 4 served as control. Oral treatment of animals was done daily from gestation day 7 to gestation day 20. Upon delivery and weaning on postnatal day 21 (PND 21), behavioural assessment was done on the postpartum mice and immediately followed by sacri ce for assessment of histological and neuroendocrine markers. Our ndings revealed that the brain-to-body weight ratio was affected and brain oxidative stress was elevated in mice exposed to AlCl 3 and CdCl 2 during pregnancy. Given the strong association between postpartum hyperactivity, social interaction index, brain catalase, and acetylcholinesterase activity, and the brain/body weight ratio, it is plausible that these effects have played a role in the adverse behavioural abnormalities observed in the postpartum maternal mice. Moreover, it noted that in certain situations, coexposures to the metals tended to have opposite effects to single metal exposures.

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Section: Discussionsupporting

confidence: 86%

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

Biol Trace Elem Res

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“…Postpartum depression in rats causes poor maternal care and neurochemical altera琀椀ons on dams and long-las琀椀ng impairment in sociability on the o昀昀spring (ZACCARELLI-MAGALHÃES J. et.al., 2022) 15 Após a separação materna (simulação dos efeitos da DPP), as mães apresentavam maiores níveis de cor琀椀sol e menores níveis de a琀椀vidade. Quanto ao comportamento, demoravam mais para buscar seus 昀椀lhotes e cuidavam menos deles, além de não apresentarem ins琀椀ntos defensivos tão intensos com a prole.…”

Section: Resultados Conclusõesunclassified

“…Segundo Gunlicks e Weissman, não foram encontradas associações entre remissão na depressão pós-parto e melhora no comportamento infan琀椀l, de modo que o espaço amostral analisado foi limitado dado o número restrito de estudos16. Isso demonstra que a falta de estudos a respeito do tema torna a quan琀椀dade de díades mãe-bebê analisadas insu昀椀ciente para quaisquer a昀椀rmações concretas sobre a relação entre DPP e desenvolvimento cogni琀椀vo da criança 15 . Somado a isso, fatores de confusão associados aos estudos podem prejudicar o estabelecimento de uma relação precisa 2 .…”

Section: Evidências Insu昀椀cientesunclassified

O impacto da depressão pós-parto no desenvolvimento cognitivo infantil

Araújo,

Alves,

Araújo

et al. 2024

J Health Biol Sci.

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Objetivo: avaliar as consequências da depressão pós-parto no desenvolvimento cognitivo infantil. Métodos: trata-se de uma revisão narrativa, com caráter analítico quantitativo, realizada por meio da busca de artigos científicos publicados, nas plataformas Google Acadêmico, Scielo e PubMed, sobre a relação entre depressão pós-parto e desenvolvimento infantil. Resultados: foi selecionado um total de 23 artigos entre os três bancos de dados. Os resultados apontam que filhos de mães deprimidas são mais propensos a ter alterações no desenvolvimento cognitivo, social e linguístico do que filhos de mães não deprimidas. Entretanto, deve-se lembrar que essa alteração não acontece exclusivamente pela depressão pós-parto, uma vez que ela pode estar associada a outros fatores de risco, como condições socioeconômicas e apoio marital. Conclusão: a depressão pós-parto como fator isolado afeta o bebê de maneira sutil, mas, diante de diversos fatores ambientais e conduta parental, o efeito nocivo pode ser intensificado, o que pode prejudicar os desempenhos nos testes cognitivos, de atenção e aprendizagem. Desse modo, compreende-se que é importante incentivar um acompanhamento pré-natal que valorize a saúde mental das gestantes, para que qualquer manifestação psicológica negativa seja prontamente identificada e receba o apoio necessário o mais rápido possível.

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“…Lipids (Keim et al, 2012), vitamins (Batalha et al, 2022), iron (Noh & Lee, 2021), hormones (Aparicio et al, 2020), immune proteins (Kawano & Emori, 2015; Kondo et al, 2011) and the microbiome (Browne et al, 2019) in breast milk were reported to be influenced by the maternal depression state, which may lead to abnormal nutrients and bioactive factor supply for infants. In view of maternal milk's essential role in nutrition support for child development, including neurodevelopment, the abnormal supply of its ingredients may explain why PPD causes long‐lasting impairment of child brain development (Bardanzellu et al, 2020; Zaccarelli‐Magalhaes et al, 2023). The influence of the maternal depression state on child development through breast milk was considered as a way of intergenerational transmission of psychological problems (Bardanzellu et al, 2018; Choi et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Peptidomics analysis of human breast milk from women with postpartum depression reveals its potential pathogenesis

Wang

Mei

et al. 2023

Intl J of Devlp Neuroscience

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Background Postpartum depression (PPD) is a prevalent psychiatric disorder during the postnatal period, and it exerts adverse impacts not only on mothers but also on infants, impairing the well‐being of the whole family. However, the role of peptides in the breast milk of mothers with PPD has not been studied. The purpose of this study was to unveil the peptidomic profile of PPD from breast milk samples. Methods We performed comparative peptidomic profiling of human breast milk from PPD and control mothers using liquid chromatography–tandem mass spectrometry technology with iTRAQ‐8 labelling. GO and KEGG pathway analyses of precursor proteins were used to predict the underlying biological functions of differentially expressed peptides (DEPs). Ingenuity Pathway Analysis (IPA) was further performed to explore the interactions and involved pathways of DEPs. Results A total of 294 peptides from 62 precursor proteins were identified to be differentially expressed in the breast milk of PPD mothers compared with the control group. Bioinformatics analysis predicted that these DEPs were associated with ECM–receptor interaction, neuroactive ligand‐receptor interaction, cell adhesion molecule binding and oxidative stress in macrophages. These results indicate that DEPs from human breast milk may play a part in PPD and become promising noninvasive biomarkers.

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Postpartum depression in rats causes poor maternal care and neurochemical alterations on dams and long-lasting impairment in sociability on the offspring

Cited by 11 publications

References 98 publications

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

O impacto da depressão pós-parto no desenvolvimento cognitivo infantil

Peptidomics analysis of human breast milk from women with postpartum depression reveals its potential pathogenesis

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