Postpartum fatty liver in high-producing dairy cows in practice and in animal studies. The connection with health, production and reproduction problems

Wensing, Th.; Kruip, Th.A.M.; Geelen, M.J.H.; Wentink, G. H.; Top, A.M. van den

doi:10.1007/bf02652596

Cited by 34 publications

(24 citation statements)

References 6 publications

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“…BHB, NEFA), and the levels of most of the hormones regulating energy homeostasis (e.g. insulin, IGF-1, T 4 and T 3 ) were similar to those determined in feedrestricted Chelikani et al, 2004) or high-producing (Wensing et al, 1997) postpartum dairy cows, and reflected NEB-related tendencies (Ronge et al, 1988;Chilliard et al, 1998;Veerkamp et al, 2003). In accordance with the experiences of Henze et al (1998), these findings reinforce the supposed role of lower than normal secretory capacity of pancreatic β-cells and/or the low level of insulin in plasma, as primary endocrine factors in the pathogenesis of pregnancy toxaemia.…”

Section: Discussionsupporting

confidence: 63%

“…Therefore in the affected dams the developing follicles were exposed to all the hyperketonaemia-related metabolic and endocrine changes. The long-lasting effects of NEB and its decompensation (ketosis, fatty liver) on intrafollicular steroidogenic capacity and oocyte quality are well documented in high-producing dairy cows (Wensing et al, 1997;Kruip et al, 1999;O'Callaghan and Boland, 1999;Gwazdauskas et al, 2000;Walters et al, 2002;Veerkamp et al, 2005 and. So, the poor reproductive performance of our formerly hyperketonaemic ewes could be based mainly on an analogous follicular malfunction.…”

Section: Discussionmentioning

confidence: 99%

“…The non-responders had lower IGF-1 and leptin levels than those ovulated after this treatment. It was concluded that the subclinical form of ovine ketosis is characterised by complex endocrine altera-In postpartum dairy cows the negative energy balance (NEB) and mainly its decompensation (ketosis, fatty liver disease) are characterised by numerous metabolic changes, which are known to postpone the resumption of cyclic ovarian function, impair the quality of oocyte, and diminish the capacity of intrauterine and intramammary antimicrobial defence mechanisms, predisposing the affected animal to puerperal metritis and mastitis (Wensing et al, 1997;Chilliard et al, 1998;Suriyasathaporn et al, 2000;Jánosi et al, 2003;Veerkamp et al, 2003). A lower ratio of insulin to glucagon and growth hormone has been demonstrated to act as the main endocrine factor (Sartin et al, 1988) in the pathogenesis of bovine ketosis.…”

mentioning

confidence: 99%

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Endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season

Kulcsár¹,

Dankó²,

Delavaud³

et al. 2006

Acta Veterinaria Hungarica

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Ketosis was diagnosed in a flock of Merino ewes that conceived from synchronised oestrus in the early autumn period. On day 140 of pregnancy the ewes were sampled for determination of βOH-butyrate (BHB), AST, glucose, nonesterified fatty acids (NEFA), total cholesterol (TCH), insulin, T 4 , T 3 , cortisol, IGF-1 and leptin. The results were evaluated according to the number of fetuses born some days later and the presence of hyperketonaemia (BHB: ≥ 1.60 mmol/l). In May, about 3 months after lambing, cyclic ovarian function was induced (Cronolone + eCG), and the ewes were inseminated artificially (AI) 48 h after the removal of gestagen-containing sponge. At the time of AI and 10 days later blood samples were collected again to check the plasma levels of the same constituents as previously (in samples taken at AI), and to monitor the ovarian response by assaying progesterone (in both samples). On day 140 of gestation significantly lower BHB levels were detected in dams with single (n = 41) than in those with twin (n = 57) pregnancies. Hyperketonaemia was found only in ewes bearing twins (n = 27). These animals had higher NEFA and cortisol, and lower TCH, insulin, IGF-1, leptin and T 3 levels than their normoketonaemic twin-bearing flockmates, and those with single pregnancy. The blood glucose concentrations varied within a wide range, and the means of groups did not exhibit any significant differences. The formerly hyperketonaemic individuals were characterised by lower leptin level 3 months after lambing, and they showed a poorer response to the cycle-induction procedure than the others. The non-responders had lower IGF-1 and leptin levels than those ovulated after this treatment. It was concluded that the subclinical form of ovine ketosis is characterised by complex endocrine altera-

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season

Kulcsár¹,

Dankó²,

Delavaud³

et al. 2006

Acta Veterinaria Hungarica

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“…Oocytes were harvested, matured in vitro, fertilized and cultured. The production of embryos from oocytes harvested from day 81 to day 120 was significantly lower in experimental animals compared to control animals (46). In the same study it was observed that a concentration of 1 mM NEFA in the maturation medium substantially decreased the percentage of oocytes from experimental cows reaching metaphase-II after 16 h incubation when compared to controls.…”

Section: Fertility Aspectsmentioning

confidence: 76%

Studies on hepatic lipidosis and coinciding health and fertility problems of high‐producing dairy cows using the “Utrecht fatty liver model of dairy cows”. A review

Geelen

Wensing

2006

Veterinary Quarterly

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“…During the transition period, and particularly during the two weeks following parturition, dairy cows are faced with an inevitable energy deficit (NEB), which will play a crucial role for the remainder of lactation (Wensing et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

An Attempt to Prevent Production Diseases in Dairy andad hocTreatment Cows by Intense Monitoring

Coiatelli¹,

Giordano

Sicilia³

et al. 2015

Italian Journal of Animal Science

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A trial has been performed on 201 dairy cows from two Italian commercial herds in order to verify whether the mitigation of a recognized negative energy balance (NEB) by a therapeutic mean may influence the incidence of peri-partum diseases. All animals were tested for beta-hydroxybutyrate (b-HOB) and non-esterified fatty acids (NEFA) three times a week from 2 weeks before the expected due time to 2 weeks after calving. Animals whose blood levels were above b-HOB>1.2 or NEFA>0.5 mmol/L were declared POSITIVE and then split in two groups. Group T animals (n=57) were treated with a glycogenic treatment (ENERGAN KETOSIS, Virbac). The treatment was repeated daily as long as biochemical values remained abnormal. Group C animals (n=48) served as untreated controls. Animals with values within the physiological range over the study period were said NEGA-TIVE (n=96). This study confirmed that animals presenting excessive b-HOB or NEFA concentrations show a higher risk to get sick during the study period (P<0.05), the major risk being clinical ketosis (P<0.01) and in a lesser extend retention of the placenta (P=0.09). The application of a glycogenic treatment did not show an impact on blood metabolite levels due to huge individual differences. However, application of the treatment for an average duration of 5 days tends to reduce the incidence of all the diseases related to a NEB. Moreover, untreated control animals were more likely to get dislocation of the abomasum (P<0.05) than NEGATIVE animals whereas treated animals were not.

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Postpartum fatty liver in high-producing dairy cows in practice and in animal studies. The connection with health, production and reproduction problems

Cited by 34 publications

References 6 publications

Endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season

Endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season

Studies on hepatic lipidosis and coinciding health and fertility problems of high‐producing dairy cows using the “Utrecht fatty liver model of dairy cows”. A review

An Attempt to Prevent Production Diseases in Dairy andad hocTreatment Cows by Intense Monitoring

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