Postpartum Group B streptococcal meningitis

George, IA; Mathews, Jiji Elizabeth; Mathews, K.P

doi:10.4103/0022-3859.39208

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…Pored širokog spektra invazivnih neonatalnih infekcija, kolonizacija ovom bakterijom je povezana sa komplikacijama u trudnoći, kao što su prevremeni porođaj i intrauterina smrt ploda (2,3). Osim infekcija novorođenčeta, GBS može da dovede do značajnih infekcija trudnica, kao što su endometritis, mastitis sa pojavom apscesa, meningitis i sepsa (4)(5)(6)(7).…”

Section: Uvodunclassified

Detection of antibiotic resistance and capsular types of group B streptococci isolated from vaginal swabs of pregnant women

Paunović,

Kekić,

Kabić

et al. 2023

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Introduction: Group B streptococcus (GBS) is an opportunistic pathogen that colonizes the gastrointestinal and genital tract of 10 - 30% of healthy people. It can cause early or late-onset neonatal disease manifested as pneumonia, sepsis, and meningitis. Penicillins are the first-choice therapy and prophylaxis of mother-to-child transmission. In the case of penicillin allergy, macrolides or vancomycin are used. Aim: The objectives of study were to determine antimicrobial susceptibility and macrolides resistance phenotypes of GBS isolates, as well as to determine capsular types (CPS) and detection of hypervirulent ST17 clone. Material and methods: From January 1st to December 31st 2021, 134 GBS isolates were collected from vaginal swabs of pregnant women. Identification was performed using conventional microbiological methods and molecular detection of species-specific dltR gene. The disk diffusion method was used to test antibiotic resistance according to EUCAST standards. Capsular typing was conducted by multiplex PCR method. A hypervirulent ST17 clone was identified by the detection of the hvgA gene using PCR. Results: All isolates were susceptible to penicillin, vancomycin, and fluoroquinolones. Tetracycline resistance was the most common, detected in 81.3% (109/134) strains. Macrolide resistance was detected in 3.3% (50/134) of isolates, while 14.9% (20/134) showed resistance to high doses of gentamicin. Resistance to chloramphenicol was noticed in 1.5% (2/134) isolates. The most common macrolide resistance phenotype was cMLS (31/50, 62.0%). The most identified CPS were V found in 33 isolates (25.0%) and III identified in 30 strains (22.0%). A hypervirulent ST17 clone was detected in 12.7% (17/134) of isolates; 15 belonged to CPS III and 2 to CPS IV. Conclusion: The high frequency of macrolide resistance in group B streptococci isolated from colonized pregnant women is a severe public health concern. Also, the detection of numerous CPS III isolates and ST17 clones indicates the need for continuous screening and monitoring of the prevalence of GBS infections in pregnant women and neonates.

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Section: Uvodunclassified

Detection of antibiotic resistance and capsular types of group B streptococci isolated from vaginal swabs of pregnant women

Paunović,

Kekić,

Kabić

et al. 2023

Medicinski podmladak

View full text Add to dashboard Cite

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“…A pesar de que la incidencia de bacteriemia por esta causa es un 10% má s frecuente tras la realizació n de una cesá rea 7,9,10 , todos los casos de meningitis ocurrieron en pacientes con parto vaginal. Otro de los factores para la aparició n de bacteriemia es el posible papel de la episiotomía como puerta de entrada desde donde penetran los microorganismos hacia el torrente sanguíneo 6,7,9,10 . De cualquier manera, estas teorías intentan explicar el paso del S. agalactiae a la sangre, pero có mo este produce la infecció n meníngea está aú n por clarificar.…”

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