Postpartum maternal exposure to predator odor alters offspring antipredator behavior, basal HPA axis activity and immunoglobulin levels in adult Brandt’s voles

Wu, Ruiyong; Li, Shan; Huang, Yefeng; Pang, Jinyue; Yong-jian, Cai; Zhang, Xinyue; Jiang, Tianyi; Yang, Shengmei; Wei, Wanhong

doi:10.1016/j.bbr.2021.113532

Cited by 5 publications

(1 citation statement)

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“…Repeated exposure to cat urine in-duces behavioral and physiological habituation in adolescent and adult voles [61,62]. CO exposure during adolescence, pregnancy, and the postpartum period has crossgenerational effects [63][64][65][66][67]. Recent evidence indicates that adolescent CO exposure influences adolescent social contact and adult parental behavior of Brandt's voles [38].…”

Section: Introductionmentioning

confidence: 99%

Adolescence Predatory Risk Alters Social Behaviors and Cognitive Ability and Central Oxytocin and Vasopressin Expression in Adult Brandt’s Voles

Pang

et al. 2022

Neuroendocrinology

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Introduction: Stress during adolescence causes long-term behavioral changes in adulthood. We previously found that adolescent exposure to predatory risk augments adolescent social contact and adult parental behavior in Brandt’s voles (Lasiopodomys brandtii). Methods: Here we determined whether this experience alters sexual behavior, pair-bond formation, and recognition ability, as well as basal HPA axis activity, central oxytocin (OT), and arginine-vasopressin (AVP) expression in adulthood. Results: In the social interaction test, repeated cat odor (CO) exposure enhanced the frequency of lordosis by female voles toward an unfamiliar opposite-sex conspecific. CO voles preferred to engage with their partners after 48 h cohabitation whereas the control groups did not, which may reflect stable pair bonds in the CO treatment group. Furthermore, adolescent exposure to CO inhibited novel object and place recognition ability, while it influenced social recognition only among adult males. No effect of adolescent CO exposure was observed for basal HPA axis activity, showing a habituation effect. Finally, we found that CO exposure increased OT and decreased AVP expression in the hypothalamus, including the paraventricular nucleus and anterior hypothalamus. The levels of OT in the medial amygdala were lower, and AVP in the lateral septum was higher in CO voles compared with the control. Discussion/Conclusion: These findings demonstrate that adolescent exposure to predator risk promotes adult reproductive behavior of Brandt’s voles. Deficits in recognition ability may necessitate alterations in reproductive strategies to enhance inclusive fitness. OT and AVP systems may play a modulatory role in the alteration of social behaviors elicited by adolescent predatory risk.

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