Spontaneous coronary artery dissection (SCAD) is still today an underdiagnosed disease that occurs in 0.1-1.1% of the major angiographic series and represents 0.1-4% of all acute coronary syndrome (1-3). Nevertheless, these findings are still today sorely underestimated due to the absence of angiographic hallmarks in more than 70% of cases (4). According to the Literature, in several cases, an intravascular imaging, namely optical coherence tomography analysis (OCT) and intravascular ultrasound images (IVUS), is mandatory for recognize a dissection (3-7).Recently the spotlights were turned on for this entity thanks to the initiatives of European and American societies of cardiology through proper study groups. In this light, we have launched an Experts' survey whose results should be published very soon (8).With this in mind, we have greatly appreciated the effort of this Journal to pay attention to this underdiagnosed entity (9), in this light we recently published an intriguing score system for a faster and efficient SCAD diagnosis (10).Here we present an emblematic case of a 58-year old, smoker, male admitted at our department for unstable angina (UA). ECG and echo did not show abnormalities. Coronary angiography (CA) not showed stenosis of right coronary artery (RCA) but a retrograde flow to middle left anterior descending artery (LAD) ( Figure 1A). Left coronary selective angiography showed a small haziness image at the ostium of the LAD, mimicking a coronary calcification (11), and a significative stenosis, a little further down, at the middle tract ( Figure 1B).With these premises we performed an intravascular ultrasound analysis (IVUS) that showed a 30% stenosis at proximal tract without a clear image of dissection ( Figure 1C), so we decided to position a drug-eluting stent (DES) at mid-LAD with a good final result ( Figure 1D). The patient was discharged after 2 days in optimized medical therapy.After 5 days the patient came back to hospital with angina pectoris and pain radiating up to the neck due to a newer non-ST-elevation myocardial infarction (NSTEMI). Thus we performed a new CA that showed an image mimicking a "vasospasm" suspected for SCAD at distal RCA (Figure 2A,B), moreover, an inexplicable coronary collateral circulation to distal RCA from distal LAD was highlighted ( Figure 2C).After administration of intracoronaric the image of SCAD was strongly suspected through the pathognomonic morphology of parallel double-lumen with contrast dye separated by a radiolucent flap ( Figure 2B) but, according to our score (10), we decided to perform an OCT. The Abstract: Spontaneous coronary artery dissection (SCAD) is still today an underdiagnosed disease due to the absence of angiographic hallmarks in more than 70% of cases. In several cases, an intravascular imaging is a sole tool for recognizing a dissection. Particularly, optical coherence tomography analysis (OCT) could represent the gold standard technique of easy interpretation and prompt diagnosis. Here we present a rare case of multivessel spont...