Postpartum psychiatric disorders

Meltzer‐Brody, Samantha; Howard, Louise M.; Bergink, Veerle; Vigod, Simone N.; Jones, Ian; Munk‐Olsen, Trine; Honikman, Simone; Milgrom, Jeannette

doi:10.1038/nrdp.2018.22

Cited by 241 publications

(208 citation statements)

References 248 publications

(230 reference statements)

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“…2018). Risk factor screening may be conducted after symptom screening has occurred, or may be included in the development of screening tools which assess both symptoms and risk (Austin et al .…”

Section: Discussionmentioning

confidence: 99%

The development of an ultra-short, maternal mental health screening tool in South Africa

et al. 2019

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Purpose.The burden of common perinatal mental disorders (CPMD) in low-and-middle-income countries is substantially higher than high-income countries, with low levels of detection, service provision and treatment in resource-constrained settings. We describe the development of an ultra-short screening tool to detect antenatal depression, anxiety disorders and maternal suicidal ideation.Methods.A sample of 376 women was recruited at a primary-level obstetric clinic. Five depression and anxiety symptom-screening questionnaires, demographics and psychosocial risk questionnaires were administered. All participants were assessed with the Mini-International Neuropsychiatric Interview (MINI), a structured, diagnostic interview. Screening tool items were analysed against diagnostic data using multiple logistic regression and receiver operating curve (ROC) analysis.Results.The prevalence of MINI-defined major depressive episode (MDE) and/or anxiety disorders was 33%. Overall, 18% of participants expressed suicidal ideation and behaviour, 54% of these had no depression or anxiety diagnosis. Multiple logistic regression identified four screening items that were independently predictive of MDE and anxiety disorders, investigating depressed mood, anhedonia, anxiety symptoms and suicidal ideation. ROC analysis of these combined items yielded an area under the curve of 0.83 (95% CI 0.78–0.88). A cut-off score of 2 or more offered a sensitivity of 78% and specificity of 82%.Conclusion.This novel screening tool is the first measure of CPMD developed in South Africa to include depressed mood, anxiety symptoms and suicidal ideation. While the tool requires further investigation, it may be useful for the early identification of mental health symptoms and morbidity in the perinatal period.

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Section: Discussionmentioning

confidence: 99%

The development of an ultra-short, maternal mental health screening tool in South Africa

et al. 2019

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“…Postpartum depression (PPD) refers to a depressive episode with moderate‐to‐severe severity in four weeks after delivery (Segal, Marty, & Coolidge, 2017). Reviews have reported a prevalence of PPD in low‐income and middle‐income countries, ranging from 14% to 20%, higher than that in high‐income countries (Ding, Chen, & Di, 2014; Fisher et al., 2012; Meltzer‐Brody et al., 2018). More and more researches focused on PPD because PPD has adverse impacts both on new mothers and infants.…”

Section: Introductionmentioning

confidence: 99%

Postpartum depression and its correlates in middle‐class women in Hunan, China

Guan

Bai

Qin

et al. 2020

Asian Soc Wrk & Pol Rev

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Postpartum depression (PPD) has a negative impact on both infants and women. The middle‐class group is rapidly expanding with increased but unmet psychological needs. To determine the risk and its correlates of PPD in middle‐class women in Hunan, China. A sample of 306 middle‐class puerperae from obstetric wards of a large general hospital was enrolled in the study. Our results showed 55.6% middle‐class women were suspected PPD. Related risk factors included a history of complications, pregnancy stress, subjective support, and interaction effect between objective support and negative coping. The protective factors included objective support and an interaction effect between subjective support and negative coping. Early assessment and individualized guidance in terms of social support and coping to identify and prevent PPD in this population are required.

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“…Perinatal depression (PND) is a debilitating disorder that occurs during pre‐ to postpartum transition with a prevalence of 19% . PND has long‐term detrimental effects on mother–infant bonding, infant wellbeing, and socio‐cognitive development and involves both genetic and environmental factors . Mechanisms related to sex‐steroid hormonal fluctuations and alterations in the serotonergic system have been suggested to underlie the pathobiology of PND.…”

Section: Introductionmentioning

confidence: 99%

Genome‐wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms

Mehta

Rex‐Haffner

Søndergaard

et al. 2019

Acta Psychiatr Scand

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Frokjaer VG. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms.Objectives: Sensitivity to sex-steroid hormone fluctuations may increase risk for perinatal depression. We aimed to identify genome-wide biological profiles in women demonstrating sensitivity to pharmacological sex-hormone manipulation with gonadotrophinreleasing hormone agonist (GnRHa). Methods: Longitudinal gene expression (Illumina Human HT12.v4) and DNA methylation data (Infinium HumanMethylation450K BeadChip) from 60 women (30 GnRHa, 30 placebo) were generated (Trial ID: NCT02661789). Differences between baseline and two followup points (initial stimulation-and subsequent early suppression phase) in the biphasic ovarian hormone response to GnRHa were assessed using linear mixed effects models. Results: Genome-wide analysis revealed 588 probes differentially expressed from GnRHa intervention to first stimulatory phase followup (intervention group 9 time) after 10% fdr multiple testing correction. Of these, 54% genes were also significantly associated with estradiol changes over time (proxy for GnRHa response magnitude), 9.5% were associated with changes in depressive symptoms, and 38% were associated with changes in neocortical serotonin transporter binding. The genes were implicated in TGF beta signaling, adipogenesis, regulation of actin cytoskeleton, and focal adhesion pathways and enriched for DNA methylation changes (P = 0.006). Conclusions: These findings point toward an altered peripheral blood transcriptomic landscape in a pharmacological model of sex-hormoneinduced depressive symptoms. Significant outcomes• These data in a pharmacological model of sex-hormone-induced depressive symptoms highlight an altered peripheral blood transcriptomic and epigenomic landscape.• Gene expression and DNA methylation hold promise as biomarkers to help identify women at high risk for developing depressive episodes in relation to hormonal transitions. Limitations• The study may not have enough power to detect subtle gene expression and DNA methylation changes.• The lack of validation experiments is a caveat.

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Postpartum psychiatric disorders

Cited by 241 publications

References 248 publications

The development of an ultra-short, maternal mental health screening tool in South Africa

The development of an ultra-short, maternal mental health screening tool in South Africa

Postpartum depression and its correlates in middle‐class women in Hunan, China

Genome‐wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms

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