Postpartum Restoration of Pregnancy-Induced Cholecystoparesis and Prolonged Intestinal Transit Time

Braverman, D; Herbet, Dina; Goldstein, Robert M.; Persitz, Emanuel; Eylath, Uri; Jacobsohn, W Z

doi:10.1097/00004836-198812000-00014

Cited by 14 publications

(8 citation statements)

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“…It is obvious that the mechanical effect of the gravid uterus on gastric emptying is negligible. On the other hand, human pregnancy prolongs small intestinal transit and is followed by postpartum correction [3,4,13]. A similar inhibition is Fig.…”

Section: Discussionsupporting

confidence: 52%

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Disturbed Small Intestinal Motility in the Late Rat Pregnancy

Chang

Lee

Yeh³

et al. 1998

Gynecol Obstet Invest

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We investigated whether various periods of pregnancy might disturb rat gastrointestinal motility. When the proestrus of female rats occurred, they were housed with male rats. Motility studies were conducted on day 7 (first period), day 14 (second) and day 21 (third) of pregnancy, respectively. After the orogastric feeding of radiochromium marker, rats were sacrificed 15 min later. Gastric emptyings of pregnant rats measured at various periods did not differ from the nonpregnant diestrus controls. The geometric center represented intestinal transits in the first, second and third periods of pregnancy and controls were (mean ±SEM) 4.54 ± 0.25, 4.47 ± 0.17, 3.61 ± 0.27 and 4.98 ± 0.13, respectively (p < 0.01) while their plasma progesterone levels were 15.6 ± 2.6, 18 ± 1.4, 7.1 ± 0.5 and 8.6 ± 0.4 ng/ml, respectively (p < 0.01). This shows that late pregnancy inhibits small intestinal transit, whereas gastric emptying remains unchanged. Altered progesterone during pregnancy is not a main mediator to disturb intestinal transit.

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Section: Discussionsupporting

confidence: 52%

“…Serum progesterone and estradiol levels were markedly increased during pregnancy [4,13]. These hormonal changes are probably responsible for GI dysmotility.…”

Section: Discussionmentioning

confidence: 95%

Disturbed Small Intestinal Motility in the Late Rat Pregnancy

Chang

Lee

Yeh³

et al. 1998

Gynecol Obstet Invest

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“…OCTT is significantly prolonged in late pregnancy compared with control and postpartum values, during the follicular phase of the menstrual cycle. 17 Delayed OCTT has previously been observed during the second and third trimesters of pregnancy in humans, 18 as well as in animal studies. 19 Chang et al 20 investigated whether rat gastrointestinal motility was disturbed during various periods of pregnancy.…”

Section: Discussionmentioning

confidence: 85%

Gastric emptying and orocecal transit time in pregnancy

Chiloiro

Darconza

et al. 2001

Journal of Gastroenterology

169

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“…14 After delivery, bile composition and gallbladder movements return to normal and therefore, sludge or gallstones may resolve. 15,16 In this study, incidence of gallstone and sludge formation during pregnancy was 5.7% and 2.9%, respectively. The observation seems to be consistent with that in a study where during pregnancy in Bangladesh.…”

Section: Discussionmentioning

confidence: 53%

Prevalence of gallstones and biliary sludge formation during pregnancy detected by ultrasonography

Saha

Kumar³

et al. 2017

Mediscope

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The risk of gallstones is thought to increase with number of pregnancies. Cholesterol gallstones are more prevalent in women than men and primarily related to sex steroids, particularly progesterone. During pregnancy there are changes in bile composition and gallbladder motility that promote gallstone formation. This study was conducted to determine incidence and outcome of pregnancy related biliary sludge and gallstone formation. Two hundred and nine consecutive expectant women were evaluated by ultrasonography at 1st trimester, 3rd trimester and at 4-6 weeks after delivery. Socio-demographic, medical and obstetrical history were taken and recorded. Incidence of gallstone and sludge formation were found 5.7% and 2.9%, respectively. The results suggest that pregnancy may be a risk factor for gallstone and biliary sludge formation.Mediscope Vol. 4, No. 2: Jul 2017, Page 21-24

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Postpartum Restoration of Pregnancy-Induced Cholecystoparesis and Prolonged Intestinal Transit Time

Cited by 14 publications

References 0 publications

Disturbed Small Intestinal Motility in the Late Rat Pregnancy

Disturbed Small Intestinal Motility in the Late Rat Pregnancy

Gastric emptying and orocecal transit time in pregnancy

Prevalence of gallstones and biliary sludge formation during pregnancy detected by ultrasonography

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