Postpartum systemic capillary leak syndrome: a possible etiology

Abramov, Yoram; Galun, Eithan; Granat, Menachem; Barak, Vivian; Abramov, Dan; Plotkin, Vladimir; Samueloff, Arnon

doi:10.3109/00016349509024437

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…We assumed that transperitoneal capillary leakage was the main mechanism behind this phenomenon. Inflammatory cytokines have been reported to play an important role in capillary hyperpermeability and third‐space fluid accumulation in other gynecologic and nongynecologic disorders, such as the ovarian hyperstimulation syndrome (7), Meigs' syndrome (8), sepsis (9) and systemic capillary leak syndrome (10,11). We therefore hypothesized that these compounds may also be involved in the capillary leakage and peritoneal fluid accumulation in arrested first stage of labor.…”

mentioning

confidence: 99%

Markedly elevated levels of inflammatory cytokines in maternal serum and peritoneal washing during arrested labor

Abramov¹,

Ezra²,

Elchalal³

et al. 2004

Acta Obstet Gynecol Scand

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mentioning

confidence: 99%

Markedly elevated levels of inflammatory cytokines in maternal serum and peritoneal washing during arrested labor

Abramov¹,

Ezra²,

Elchalal³

et al. 2004

Acta Obstet Gynecol Scand

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show abstract

“…Inflammatory cytokines have been reported to play an important role in capillary hyperpermeability and third-space fluid accumulation in other gynecologic and nongynecologic disorders, such as the ovarian hyperstimulation syndrome (7), Meigs' syndrome (8), sepsis (9) and systemic capillary leak syndrome (10,11). We assumed that transperitoneal capillary leakage was the main mechanism behind this phenomenon.…”

mentioning

confidence: 99%

Markedly elevated levels of inflammatory cytokines in maternal serum and peritoneal washing during arrested labor

Abramov¹,

Ezra²,

Elchalal³

et al. 2004

Acta Obstet Gynecol Scand

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Background. The role of inflammatory cytokines in the pathophysiology of arrested labor is currently unknown. We measured levels of inflammatory cytokines in maternal serum and peritoneal washings in arrested first stage of labor to assess the possible involvement of these mediators in this obstetric disorder.Methods. This was a prospective, case-control study involving 15 women who underwent cesarean section for arrested cervical dilatation (group I), 15 controls who were operated during active labor for nonreassuring fetal heart-rate tracing (group II) and 15 controls who were operated electively (group III). Blood samples were drawn from all women shortly before the operation. The presence of peritoneal fluid was assessed and peritoneal washings were obtained during the operation. All samples were assayed for the inflammatory cytokines interleukin (IL)-1b, IL-6, IL-8 and soluble IL-2 receptor (sIL-2R) by solid-phase enzyme-linked immunosorbent assay (ELISA). Results. All women from group I and one patient (6.7%) from group II had some degree of peritoneal fluid accumulation, while none from group III had any. Serum samples from group I contained significantly higher IL-1b, IL-6, IL-8 and IL-2R levels than both control groups. Peritoneal washings from group I contained significantly higher IL-1b, IL-6 and IL-8 but similar IL-2R levels.Conclusions. Arrested first stage of labor is associated with peritoneal fluid accumulation and increased levels of inflammatory cytokines in both serum and peritoneal fluids. Inflammatory cytokines may therefore be involved in the pathophysiology of arrested labor.

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Cytokine-Induced Vascular Leak Syndrome

Baluna¹

2007

Methods in Pharmacology and Toxicology

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Postpartum systemic capillary leak syndrome: a possible etiology

Cited by 6 publications

References 23 publications

Markedly elevated levels of inflammatory cytokines in maternal serum and peritoneal washing during arrested labor

Markedly elevated levels of inflammatory cytokines in maternal serum and peritoneal washing during arrested labor

Markedly elevated levels of inflammatory cytokines in maternal serum and peritoneal washing during arrested labor

Cytokine-Induced Vascular Leak Syndrome

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