Postpartum Thrombosis of a Developmental Venous Anomaly

Prasad, Sashank; Hurst, Robert W.; Kasner, Scott E.

doi:10.1212/01.wnl.0000338623.26818.5f

Cited by 8 publications

(13 citation statements)

References 6 publications

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“…In addition, 21% of patients underwent decompressive surgery for hematoma evacuation . Evaluation for a hypercoagulable state is recommended in patients with thrombosed DVA …”

Section: Symptomatic Dvamentioning

confidence: 89%

“…DVAs characteristically are drained by a single dominant collector vein; however, in 5.9‐9.1%, multiple collecting veins may be present . Given the role of the DVAs as primary venous drainage of brain parenchyma, surgical removal of a DVA could potentially have untoward consequences such as venous infarction and hemorrhage …”

Section: Drainage and Anatomic Locationmentioning

confidence: 99%

“…On brain CT scans without contrast injection, small DVAs may not be visualized unless they are large, in which case they are usually evident by the demonstration of slightly hyperdense blood (Fig ) compared to the normal brain parenchyma. Marked hyperdensity of the collecting vein may be a sign of a thrombosed DVA (Fig ) and warrants further investigation . CT can also demonstrate parenchymal abnormalities related to DVA such as calcification, overt hemorrhage, and atrophy .…”

Section: Neuroimaging Findings: Ct Conventional Mri and Cerebral Anmentioning

confidence: 99%

“…DVAs are considered congenital abnormalities of the venous system of the brain. The most widely described etiology for the development of a DVA is atresia, abnormal development, or ischemia during intrauterine life with secondary development of aberrant venous architecture . Considering the angioarchitecture of medullary venous system, DVAs can be due to the absence of superficial or deep venous collectors, which causes hemodynamic imbalance.…”

Section: Introductionmentioning

confidence: 99%

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The Many Faces of Cerebral Developmental Venous Anomaly and Its Mimicks: Spectrum of Imaging Findings

Nabavizadeh

Mamourian

Vossough

et al. 2016

Journal of Neuroimaging

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Developmental venous anomalies (DVAs) are the most common cerebral vascular malformations and are usually found incidentally on neuroimaging studies. Despite the benign nature of DVAs, occasionally, they can be symptomatic. The objective of this article is to review the spectrum of imaging findings of DVAs on conventional and advanced imaging studies. In addition, neuroimaging findings of symptomatic DVAs as well as imaging mimicks will also be described to assist in the approach to differential diagnosis.

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“…In addition, 21% of patients underwent decompressive surgery for hematoma evacuation . Evaluation for a hypercoagulable state is recommended in patients with thrombosed DVA …”

Section: Symptomatic Dvamentioning

confidence: 89%

Section: Drainage and Anatomic Locationmentioning

confidence: 99%

Section: Neuroimaging Findings: Ct Conventional Mri and Cerebral Anmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Many Faces of Cerebral Developmental Venous Anomaly and Its Mimicks: Spectrum of Imaging Findings

Nabavizadeh

Mamourian

Vossough

et al. 2016

Journal of Neuroimaging

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“…The role of anticoagulation in the setting of DVA thrombosis is unclear, although extrapolating from the experience with dural sinus venous, anticoagulation may be advisable [41]. The finding should also prompt hypercoagulability evaluation [42]. In cases of suspected DVA thrombosis with hemorrhagic presentation, careful evaluation for other sources of bleeding such as CM or AVM, including angiographic evaluation, would be prudent prior to proceeding with anticoagulation.…”

Section: Thrombosismentioning

confidence: 99%

Venous Angiomas

Amin‐Hanjani

2011

Curr Treat Options Cardio Med

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Venous angiomas are currently widely referred to as developmental venous anomalies (DVAs), reflecting the prevailing concept that they represent anomalous, but functional, venous channels within the brain parenchyma. Although DVAs are not infrequently associated with other vascular malformations that harbor hemorrhage risk or can present symptomatically, isolated DVAs themselves appear to be benign lesions with little demonstrable link to hemorrhage, seizures, or headaches. Treatments to remove or occlude DVAs are consequently unnecessary. Furthermore, obliteration of a DVA can be harmful as it can lead to impairment in regional cerebral venous drainage, with the resultant risk of venous congestion, infarction, and hemorrhagic conversion, and the potential for devastating consequences from cerebral edema and mass effect. Consequently, even in the management of associated vascular malformations, it is important to preserve the DVA. In rare cases, DVAs can produce direct compressive symptoms, leading to obstructive hydrocephalus or neurovascular compression. In such cases, cerebrospinal fluid diversion or direct microvascular decompression, respectively, without disruption of the DVA itself is appropriate. In the uncommon setting of spontaneous DVA thrombosis leading to venous infarction, anticoagulation, as recommended for dural and cortical venous thrombosis, is a reasonable consideration. Hemorrhagic presentation from a presumed isolated DVA should prompt careful evaluation for an associated vascular malformation as the true etiology of hemorrhage.

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Beta-Amyloid Deposition and the Aging Brain

2009

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A central issue in cognitive neuroscience of aging research is pinpointing precise neural mechanisms that determine cognitive outcome in late adulthood as well as identifying early markers of less successful cognitive aging. One promising biomarker is beta amyloid (Aβ) deposition. Several new radiotracers have been developed that bind to fibrillar Aβ providing sensitive estimates of amyloid deposition in various brain regions. Aβ imaging has been primarily used to study patients with Alzheimer's Disease (AD) and individuals with Mild Cognitive Impairment (MCI); however, there is now building data on Aβ deposition in healthy controls that suggest at least 20% and perhaps as much as a third of healthy older adults show significant deposition. Considerable evidence suggests amyloid deposition precedes declines in cognition and may be the initiator in a cascade of events that indirectly leads to age-related cognitive decline. We review studies of Aβ deposition imaging in AD, MCI, and normal adults, its cognitive consequences, and the role of genetic risk and cognitive reserve. KeywordsAging; Beta-amyloid; Brain; Cognitive reserve; fMRI; PET Normal aging is associated with measurable declines in neural and cognitive systems. There is a wealth of literature documenting age-related declines in many aspects of cognitive behavior, including decreased speed of information processing, working memory capacity, and long-term memory function. At the same time, knowledge structures are relatively preserved with age (Ghisletta and Lindenberger 2003;Hedden and Gabrieli 2004;Park et al. 2002). Recently, significant advances have been made in our understanding of the structure and function of the aging brain utilizing new neuroimaging technologies (see Park and ReuterLorenz 2009;Park and Goh 2009;Raz and Kennedy 2009; Raz and Rodrigue 2006 for reviews). At present, a central issue in cognitive neuroscience of aging research is pinpointing the precise neural mechanisms that determine cognitive outcome in late adulthood as well as identifying markers of less successful cognitive aging as early in life as possible. Predicting successful vs. pathological aging trajectories requires early identification of sensitive behavioral or neural markers prior to actual neural pathology and cognitive decline. One such promising biomarker that has received recent attention is beta amyloid (Aβ), a protein that is deposited on the brain in some individuals as they age.© Springer Science + Business Media, LLC 2009 Correspondence to: Denise C. Park, denise@utdallas.edu. Disclosures The authors have no financial disclosures to report. NIH Public Access Author ManuscriptNeuropsychol Rev. Author manuscript; available in PMC 2010 December 1. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptSignificant amyloid deposition is a characteristic feature of all patients with Alzheimer's disease (AD). However, it is also present in many normal adults; it is observed in individuals with Mild Cognitive Impairment (MCI) at a leve...

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Postpartum Thrombosis of a Developmental Venous Anomaly

Cited by 8 publications

References 6 publications

The Many Faces of Cerebral Developmental Venous Anomaly and Its Mimicks: Spectrum of Imaging Findings

The Many Faces of Cerebral Developmental Venous Anomaly and Its Mimicks: Spectrum of Imaging Findings

Venous Angiomas

Beta-Amyloid Deposition and the Aging Brain

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