Postpemphigus acanthomata: a sign of clinical activity?

Krishnan, Srivilliputtur G. Santhana; Jayaraman, Muriugaiya; Janaki, V R; Yesudian, Patrick

doi:10.1046/j.1365-4362.1997.00092.x

Cited by 22 publications

(25 citation statements)

References 5 publications

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“…Postpemphigus acanthomata (seborrhoeic keratosis like changes after healing of pemphigus lesions) was studied by Yesudian et al [36] It occurred in 25% of studied patients (13 of 52 included patients, 10 PV, 3 PF). Most commonly, it was seen over the trunk.…”

Section: Clinical Featuresmentioning

confidence: 99%

Pemphigus in India

Kanwar¹,

De²

2011

Indian J Dermatol Venereol Leprol

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Pemphigus is a chronic epidermal immunobullous disease with potentially fatal outcome. The journey of literature on pemphigus in India has come a long way in last five decades. Pemphigus in Indian patients has unique genetic, clinical, and epidemiological differences from those in the Western countries. Corticosteroids remain the mainstay of treatment for pemphigus. Dexamethasone-cyclophosphamide pulse therapy has revolutionized the management of pemphigus in India and abroad for nearly 3 decades now. Corticosteroid-based treatment, along with adjuvants, has significantly brought down the high mortality rates that had been observed in precorticosteroid era. Present day research is largely based on elucidating the pathogenesis beyond the antidesmoglein antibodies, and newer diagnostic and treatment approaches. In this article, we review various aspects of literature on pemphigus in India, on Indians abroad, or literature from other countries that are considered relevant to the topic.

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Section: Clinical Featuresmentioning

confidence: 99%

Pemphigus in India

Kanwar¹,

De²

2011

Indian J Dermatol Venereol Leprol

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“…[910] In addition to erosions and ulcers, extensive vegetating granulation arise from mucosa of oral cavity, which on histopathology, reveals granulation and a few acantholytic cells attached to it. [11] Yesudian et al .,[12] noted when healing eventually occurs in pemphigus (remission) some patients show seborrheic-keratosis-like lesions, which on histopathology, show intraepidermal cleft and few acantholytic cells within cleft; direct immunofluorescence (DIF) of such lesions show positive DIF staining indicative of disease activity. Indirect immunofluorescence (IIF) was found to be negative.…”

mentioning

confidence: 99%

“…Many studies have shown that clinical activity and duration of treatment on IIF titer were not appropriate; further, IIF is not as sensitive as DIF to detect small amounts of IgG circulating antibody. [12]…”

mentioning

confidence: 99%

“…Clinical criteria and IIF which are not sensitive enough to detect low levels of circulating antibody so cannot be used. [212] In state of remission, DIF[17–21] is more sensitive and small amounts of IgG deposited in epidermis can be easily detected, while the same amount cannot be detected by IIF. Positive IF (both IIF and DIF) in state of remission indicates an immunological activity of the disease and therefore treatment should be continued.…”

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confidence: 99%

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Pemphigus: Active or inactive?

Vaishnani¹,

Bosamiya²

2009

Indian J Dermatol

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“…Those lesions that do heal often leave hyper-or hypopigmentation with no scarring. Acanthomas may occur at sites of previous blisters [ 41 ]. Cases of cutaneous only pemphigus vulgaris are increasingly recognized [ 42 ].…”

Section: Skinmentioning

confidence: 99%