Postperfusion Syndrome in Cadaveric Liver Transplantations

Aydınlı, Bahar; Karadeniz, Ümit; Demir, Aslı; Güçlü, Çiğdem Yıldırım; Kazancı, Dilek; Koçulu, Rabia; Haytural, Candan; Özgök, Ayşegül; Bostancı, Erdal Birol; Zorlu, Ali

doi:10.5152/tjar.2016.32657

Cited by 2 publications

(2 citation statements)

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“…PRS is the acute hemodynamic disturbance and decreased mean arterial pressure of more than 30% of baseline values. It occurs within the first 5 min after reperfusion of the donor’s liver with the recipient’s blood during the transition from the anhepathic phase to the neohepathic phase, which lasts for at least 1 min [ 4 , 8 , 9 ]. It is associated with poor patient and transplanted liver outcomes [ 3 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is associated with poor patient and transplanted liver outcomes [ 3 , 10 , 11 ]. Although the definitive mechanism of this syndrome is complex and not fully understood [ 7 , 9 , 12 – 14 ], it is attributed to the release of oxygen free radicals, endotoxin, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), IL-2, vasoactive, hyperkalemic, cold, and acidotic substances of maintenance solution, donor’s liver, and recipient ischemic intestine [ 6 , 9 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Risk factors of the post-reperfusion syndrome during orthotopic liver transplantation: a clinical observational study

et al. 2022

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Background Post reperfusion syndrome (PRS) is a relatively common and life-threatening complication during orthotopic liver transplantation (OLT). It is associated with poor patient and transplanted liver outcomes. Objective This study aimed to compare the risk factors of PRS during OLT. Design Clinical-epidemiological observational retrospective study. Setting We gathered the records of patients who underwent OLT in 3 years, from May 22, 2016, to May 22, 2019, in Namazi and Bu-Ali Sina organ transplantation hospitals. Patients In this study, we assessed 1182 patients who underwent OLT. Patients were divided into two groups based on the presence or absence of PRS. Main outcome measures Diagnosing the predictors of PRS was the primary outcome of this study. Results Results showed that age > 60 years, Child-Pugh scores C, higher Model End Stage liver disease score, and preoperative sodium < 130 mmol/l (parameters of the liver recipient), increase in cold ischemic time (the donors’ parameters), and the classical technique (the surgical parameters) were the strong predictors of PRS. Conclusions The results indicated that underlying liver disease was not the predictor of PRS in the presence of other risk factors; therefore, clinicians have to consider these risk factors in patients undergoing OLT.

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