Postpolypectomy bleeding of colorectal polyps in patients with continuous warfarin and short-term interruption of direct oral anticoagulants

Harada, Hideaki; Miyaoka, Youichi; Yuki, Takafumi; Iwaki, Toru; Maeda, Gen; Nakahara, Ryotaro; Murakami, Daisuke; Ujihara, Tetsuro; Katsuyama, Yasushi; Hayasaka, Kenji; Kushiyama, Yoshinori; Fujishiro, Hirofumi; Amano, Yuji

doi:10.1016/j.gie.2020.09.046

Cited by 7 publications

(18 citation statements)

References 20 publications

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“…Detailed information about the excluded studies is presented in the supporting information. Eventually, 30 articles were included 24–53 …”

Section: Resultsmentioning

confidence: 99%

“…Only two studies mentioned the usage of epinephrine as injection solution 50,53 . As for the types of DOACs, 14 (46.67%) studies included dabigatran, rivaroxaban, apixaban, and edoxaban 24–28,32–38,41,43 . And five studies reported that the duration of withdrawal of antithrombotic agents was determined according to the guidelines published by the JGES 24,25,28,31,44 .…”

Section: Resultsmentioning

confidence: 99%

“…As for the types of DOACs, 14 (46.67%) studies included dabigatran, rivaroxaban, apixaban, and edoxaban 24–28,32–38,41,43 . And five studies reported that the duration of withdrawal of antithrombotic agents was determined according to the guidelines published by the JGES 24,25,28,31,44 . For DOACs, HB was applied in 17 studies 24,25,27,29,31–34,36,37,39,42,45,46,48,50,52 .…”

Section: Resultsmentioning

confidence: 99%

“…For DOACs, HB was applied in 17 studies 24,25,27,29,31–34,36,37,39,42,45,46,48,50,52 . Six studies just discontinued DOACs before the endoscopic procedures without the usage of HB 26,28,35,40,41,49 . For warfarin, 22 studies mentioned HB before the procedures 24,25,27,29,31–37,39–42,45,46,48–50,52,53 .…”

Section: Resultsmentioning

confidence: 99%

“…No study selected the community population as the control group. Fourteen studies did not report the non‐response rate 25,28–30,34,38,39,41,42,44,49–52 . The detailed information about each item of NOS is provided in the supporting information.…”

Section: Resultsmentioning

confidence: 99%

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Bleeding after endoscopic resection between direct oral anticoagulants or warfarin: Systematic review and meta‐analysis

Zhu

Tao

et al. 2021

J of Gastro and Hepatol

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Background and Aim Oral anticoagulants are risk factors for post‐endoscopic resection bleeding. We aimed to conduct a systematic review and meta‐analysis for the risks of post‐procedural bleeding (PPB) for direct oral anticoagulants (DOACs) and warfarin following endoscopic resection. Methods Two independent reviewers searched PubMed, Web of Science, Embase, and Cochrane Library. The Newcastle–Ottawa Scale score was used to assess the quality of the studies, the pooled odds ratio (OR) to present PPB results, and the funnel plots to assess publication bias. The Higgins I2 statistic was employed to determine the variation across studies due to heterogeneity. Results We reviewed 30 articles. PPB occurred in 586 patients on DOACs and 1782 on warfarin. The patients on DOACs had a significantly lower overall risk of PPB compared with those on warfarin (OR, 0.867, 95% confidence interval, 0.771–0.975; P = 0.017, I2 = 1.6%). Cumulative meta‐analysis showed that the PPB rate of DOACs has the trend to be lower than that of warfarin with publication year and sample size. For the subgroup of endoscopic submucosal dissection, the PPB of DOACs was significantly lower than that of warfarin (OR, 0.786; 95% confidence interval, 0.633–0.976; P = 0.029, I2 = 0%). No significant difference was observed between DOACs and warfarin for anticoagulant strategies, endoscopic procedures, and lesion location. Conclusions Compared with warfarin, DOACs have the possibility to significantly decrease the risk of PPB following endoscopic resection, especially for endoscopic submucosal dissection.

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“…Detailed information about the excluded studies is presented in the supporting information. Eventually, 30 articles were included 24–53 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Bleeding after endoscopic resection between direct oral anticoagulants or warfarin: Systematic review and meta‐analysis

Zhu

Tao

et al. 2021

J of Gastro and Hepatol

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Dabigatran etexilate/edoxaban

2021

Reactions Weekly

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Safety of cholecystectomy in patients under antithrombotic Drugs: A systematic review and meta-analysis

Shao¹,

Cui²

2022

Pak J Med Sci

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Objective: This review aimed to assess evidence on the safety of cholecystectomy in patients under antithrombotic therapy. Methods: PubMed, Embase, Science Direct, CENTRAL, and Google Scholar databases were searched from inception up to 20th January 2022 for studies comparing outcomes of patients undergoing cholecystectomy surgeries with or without concomitant antithrombotic therapy. Results: Nine studies were included. Meta-analysis revealed that the use of antithrombotic medications had no statistically significant effect on intra-operative blood loss in patients undergoing cholecystectomy (MD: 82.31 95% CI: -283.38, 448 I2=98% p=0.66). However, incidence of blood transfusion (OR: 5.65 95% CI: 1.10, 28.86 I2=83% p=0.04) and bleeding complications (OR: 8.02 95% CI: 1.71, 37.58 I2 = 71% p=0.008) were significantly increased in patients under antithrombotic therapy. Pooled analysis indicated that cholecystectomy patients under antithrombotic are at an increased risk of conversion to open surgery (OR: 2.02 95% CI: 1.21, 3.36 I2=0% p=0.007). Meta-analysis revealed significantly shorter LOS in patients under antithrombotic (MD: -5.01 95% CI: -8.29, -1.73 I2=97% p=0.03). Conclusion: Current evidence from a limited number of studies indicates that the use of antithrombotic may be associated with an increased risk of bleeding-related complications in patients undergoing cholecystectomies. Antithrombotic use may also increase the risk of conversion to open surgery in patients undergoing laparoscopic cholecystectomies. doi: https://doi.org/10.12669/pjms.38.8.7032 How to cite this:Shao X, Cui X. Safety of cholecystectomy in patients under antithrombotic Drugs: A systematic review and meta-analysis. Pak J Med Sci. 2022;38(8):2365-2372. doi: https://doi.org/10.12669/pjms.38.8.7032 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Postpolypectomy bleeding of colorectal polyps in patients with continuous warfarin and short-term interruption of direct oral anticoagulants

Cited by 7 publications

References 20 publications

Bleeding after endoscopic resection between direct oral anticoagulants or warfarin: Systematic review and meta‐analysis

Bleeding after endoscopic resection between direct oral anticoagulants or warfarin: Systematic review and meta‐analysis

Dabigatran etexilate/edoxaban

Safety of cholecystectomy in patients under antithrombotic Drugs: A systematic review and meta-analysis

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