Postprandial alterations in hemodynamics and blood pressure in normal subjects

Fagan, Timothy C.; Sawyer, Phyllis R.; Gourley, L; Lee, Jonetta T.; Gaffney, Thomas E.

doi:10.1016/0002-9149(86)90291-2

Cited by 108 publications

(55 citation statements)

References 22 publications

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“…In healthy adults, food ingestion leads to splanchnic dilatation and pooling, reduced SVR and a tendency for the BP to fall. As a consequence, HR and CO increase [17] . In this study, the fall in RBV after food was not accompanied by significant change in CO or SVR, possibly because food ingestion and UF have approximately equal but opposite effects on these parameters, thus effectively cancelling out.…”

Section: Discussionmentioning

confidence: 99%

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Haemodynamic Effects of Food Intake during Haemodialysis

Sivalingam

Banerjee²,

Nevett³

et al. 2008

Blood Purif

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Background: There is some doubt whether food intake during haemodialysis (HD) is detrimental to haemodynamic stability. Methods: We studied 20 stable non-diabetic HD patients during a single session. A standard meal was given 45 min into dialysis. Relative blood volume (RBV), cardiac output (CO), systemic vascular resistance (SVR) and extracellular fluid (ECF) resistance were monitored continuously. Total protein and albumin were measured. Results: There was a significant reduction in RBV after food ingestion (maximum reduction 3.4 ± 1.1%; p < 0.001). There was no significant change in ECF resistance, heart rate, CO or SVR. Mean arterial pressure was significantly different from pre-food levels 30 min after food (p = 0.04). The rate of change of total protein and albumin concentration was significantly higher immediately after food ingestion. Conclusions: Food intake during HD caused significant reductions in RBV, possibly related to fluid shifts from intestinal microcirculation to interstitium. CO and SVR remained stable perhaps because of the opposing effects of food ingestion and UF.

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Section: Discussionmentioning

confidence: 99%

“…The effect on blood pressure (BP) depends on the efficiency of these compensatory mechanisms [3] . Caffeine pre-treatment may ameliorate postprandial hypotension in patients with autonomic insufficiency [4] but generally its effects are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Haemodynamic Effects of Food Intake during Haemodialysis

Sivalingam

Banerjee²,

Nevett³

et al. 2008

Blood Purif

View full text Add to dashboard Cite

show abstract

“…Eating is known to influence blood pressure in healthy subjects [1] and can cause severe hypotension in patients with autonomic insufficiency [2], Postprandial hypoten sion during hemodialysis has been described previously in patients undergoing hemodialysis [3] and has been attributed to the autonomic dysfunction commonly en countered in uremic patients [3,4]. In this report, we focus on a patient undergoing chronic maintenance hemodi alysis, who suffered from severe postprandial hypoten sion resulting in an intense fear of eating, associated with a progredient weight loss.…”

Section: Introductionmentioning

confidence: 99%

Somatostatin-Induced Hyperkalemia in a Patient on Maintenance Hemodialysis

Sharma

Thiede²,

Keller³

1991

Nephron

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A 65-year-old man, who had been undergoing maintenance hemodialysis for 20 years, suffering from severe postprandial hypotension was studied on 2 consecutive interdialytic days. The drop in blood pressure resulting from the oral administration of 75 g glucose was prevented by the concomitant infusion of somatostatin (350 μg/h), but this was accompanied by severe hyperkalemia (7.4 mmol/l). Suppression of insulin by somatostatin may have contributed to the hyperkalemia by impairing cellular potassium uptake. We conclude that although somatostatin prevents postprandial hypotension, hyperkalemia may limit its use in patients with end-stage renal failure

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“…It has been reported that the effects of meals on hemodynamics are related to their amounts 3) , and the cardiac index, stroke volume, HR, and myocardial oxygen consumption are all known to increase when a larger quantity of food is ingested. The calorie count of ingested food used in studies performed in healthy subjects by Kelbaek et al 5) and Fagan et al 6) was found to be approximately 800 k c a l , w h i l e i n t h e p r e s e n t s t u d y , i t w a s approximately half the amount of those studies. With regard to the constituents of ingested food, it has been revealed that the rate of increases in the HR, blood pressure, and cardiac output was smaller when the food ingested consisted of carbohydrate rather than protein, even though they had the same calorie count 3) .…”

Section: Discussionmentioning

confidence: 90%

“…Blood flow to the digestive system increases after ingestion of food, for its digestion and absorption 3) , and is accompanied by increases in the heart rate, systolic blood pressure, and cardiac output [3][4][5][6] , in addition to changes in sympathetic nerve activity 3,5) and hormone response 3) . When exercise takes place immediately after a meal, hemodynamics are altered because of the increased b l o o d s u p p l y t o s k e l e t a l m u s c l e s , a n d , consequently, adverse effects could occur 7) , namely, a decrease in blood flow to the digestive system, imbalance of the autonomic nervous system, and nausea associated with the pendular movement of retained food in the stomach with body motions.…”

Section: Introductionmentioning

confidence: 99%

Effects of Food Intake on Physiological Responses to Cardiopulmonary Exercise Testing

Yokogawa

Ueda²,

Murase

et al. 2007

J Phys Ther Sci

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Abstract. We examined the effects of fluid and food intake on cardiopulmonary status during cardiopulmonary exercise testing (CPX). Twelve young men fasted for 12 hours, followed by CPX under three experimental conditions: 1) continuation of fasting; 2) ingestion of 420 ml of water; and 3) ingestion of 420 g of jelly. For the second and third experimental conditions a 30-min time lapse was imposed after intake of water or food before CPX. Each participant then underwent symptom-limited maximal CPX and also acted as his own control for each experimental condition. The respiratory gas exchange ratio was significantly smaller in the water condition (0.76 ± 0.06) than in the fasting (0.83 ± 0.01) and jelly (0.83 ± 0.05) conditions at rest, but no other differences in cardiopulmonary responses were evident. These findings suggest that blood distribution to skeletal muscles is prioritized at maximal exercise level even during the digestion and absorption of food. In conclusion, careful consideration should be given to the load on the cardiopulmonary system and quantity and types of fluid or food ingested, when engaging in physical exercise.

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Postprandial alterations in hemodynamics and blood pressure in normal subjects

Cited by 108 publications

References 22 publications

Haemodynamic Effects of Food Intake during Haemodialysis

Haemodynamic Effects of Food Intake during Haemodialysis

Somatostatin-Induced Hyperkalemia in a Patient on Maintenance Hemodialysis

Effects of Food Intake on Physiological Responses to Cardiopulmonary Exercise Testing

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