Postprandial Cholecystokinin Secretion in Elderly with Protein‐Energy Undernutrition

Berthélemy, Philippe; Bouisson, M; Vellas, Bruno; Moreau, J; Nicole‐Vaysse,; Albarede, J L; Ribet, A

doi:10.1111/j.1532-5415.1992.tb02136.x

Cited by 43 publications

(18 citation statements)

References 31 publications

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“…Masclee et al (20) found higher CCK concentrations in older than in younger subjects after intraduodenal fat infusion, but no significant difference in fasting CCK concentrations between the 2 age groups. Berthelemy et al (21) reported no significant difference in CCK concentrations, either in a fasting state or after a liquid meal, between well-nourished younger and older people, but did report that postprandial CCK concentrations were higher in malnourished older subjects than in well-nourished young and well-nourished older subjects. This is consistent with evidence that suboptimal energy intake, reduced body weight, or both may be associated with increased plasma CCK concentrations (29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

“…We assessed this by measuring plasma CCK, GLP-1, and PYY concentrations in response to intraduodenal lipid and glucose infusions and correlated these results with measures of appetite, food intake, and pyloric motility reported in a previous study (15). We were particularly interested in assessing the CCK response to intraduodenal lipid infusions because lipid is a more potent stimulator of endogenous CCK release than glucose (19) and there are conflicting reports about the effect of age on increases in plasma CCK concentrations produced by ingestion of lipid (20) or a mixed meal (21). We hypothesized that aging enhances the lipidinduced increase in CCK concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility

MacIntosh

Andrews

Jones

et al. 1999

The American Journal of Clinical Nutrition

225

140

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Background: Aging is associated with a decrease in appetite and a slowing of gastric emptying. The gastrointestinal hormones cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) may mediate these changes. Objective: We investigated whether aging influenced the secretion of CCK, GLP-1, and PYY and their effects on appetite and pyloric motility. Design: Eight healthy older (65-80 y) and 7 younger (20-34 y) men received isoenergetic (12.1 kJ/min) intraduodenal infusions of lipid and glucose for 120 min on separate days. Plasma CCK, GLP-1, and PYY concentrations were measured. Results: Plasma CCK concentrations were higher in older than in younger subjects (P = 0.004) as a result of higher baseline values (4.7 ± 0.2 compared with 3.2 ± 0.2 pmol/L; P < 0.0001) and a greater rise during lipid infusion (increase from baseline: 7.1 ± 0.5 compared with 5.3 ± 0.6 pmol/L; P = 0.048). Plasma GLP-1 and PYY concentrations were not significantly different between groups. The decrease in hunger during intraduodenal lipid infusion was inversely related to the increase in CCK, GLP-1, and PYY in younger but not older subjects. During intraduodenal lipid infusion, the increase in isolated pyloric pressure wave (IPPW) frequency was positively related to GLP-1 and PYY and the increase in IPPW amplitude was positively related to CCK in older but not younger subjects, whereas the increase in IPPW amplitude and pyloric tone was negatively related to GLP-1 and PYY in younger subjects. Conclusions: Human aging is associated with increased CCK concentrations, which may contribute to the slowing of gastric emptying, mediated by increased pyloric motility. The role of increased plasma CCK concentrations in mediating the agerelated decrease in appetite remains to be established.Am J Clin Nutr 1999;69:999-1006. KEY WORDSCholecystokinin, CCK, glucagon-like peptide 1, GLP-1, peptide YY, PYY, appetite, pylorus, gastric emptying, small intestine, elderly, men, aging INTRODUCTIONAging is associated with a decrease in appetite and food intake (1, 2); additionally, body weight tends to decrease from 65 to 70 y of age (1). This anorexia of aging may predispose the elderly to pathologic weight loss and increased morbidity and mortality (3). The causes of the anorexia of aging are unknown but are likely to be multifactorial.Appetite is controlled by a central system that is responsible for the initiation of eating and that is held in check by a peripheral satiety system, which is activated by the presence of food in the gastrointestinal tract (3). An important mediator of gastrointestinal satiety signals is thought to be the release of gastrointestinal satiety hormones, including cholecystokinin (CCK) (4, 5), bombesin, glucagon, and glucagon-like peptide 1 (GLP-1) (6), induced by interaction of nutrients with receptors in the small intestine (4).Gastric emptying of nutrients is slightly slower in healthy elderly than in young adults (7,8) and there is evidence that this may contribute to increased satiation, perhaps by p...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility

MacIntosh

Andrews

Jones

et al. 1999

The American Journal of Clinical Nutrition

225

140

View full text Add to dashboard Cite

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“…Another possible factor is the increased postprandial cholecystokinin hormone in malnutrition based on the work of Berthelemy et al (1992). This hormone inhibits the proximal gastric contraction and hence adds to the delayed GET in PEM (Lieverse et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic gastric emptying in protein energy malnutrition: effect of type of meal and nutritional recovery

et al. 2004

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Objective and Design: The earlier reports of disturbed gastric motility in protein energy malnutrition (PEM) point out to its possible contribution in the difficulties faced during nutritional rehabilitation. This study was thus designed to assess the ultrasonographic gastric emptying time (GET) using 20 ml/kg body weight of both liquid and semisolid meals, in 27 patients suffering from PEM as well as in 15 healthy matching infants to delineate any defect present, its degree in different types of PEM and the effect of nutritional rehabilitation. Patients: The patients were recruited from the in-patient department of Children's Hospital, Ain Shams University, Cairo, Egypt. They were divided into three groups: 10 marasmic infants, 10 marasmic kwashiorkor (marasmic KWO) and seven kwashiorkor (KWO) cases. Ultrasonographic GET assessment was carried out within 72 h of admission and 3077 days after nutritional rehabilitation. Results: The gastric half-emptying time T(1/2) of both liquid and semisolid meals was markedly prolonged in patients with marasmus and marasmic KWO. It was more delayed for the semisolid than the liquid meals. This delay was reversible after nutritional rehabilitation of the patients, indicating that it was secondary to the malnourished status. On the other hand, T(1/2) of both liquid and semisolid meals showed no statistically significant delay in the KWO group and nutritional rehabilitation added no further to the results. Conclusion: PEM, especially marasmus and marasmic KWO, causes a delay in GET, which is reversible on nutritional recovery. This must be considered during nutritional rehabilitation of such patients to decrease the duration of their hospitalization and thus decrease the morbidity in PEM. Sponsorship: This study was supported by a university fund from

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“…Indeed, it has been reported that CCK concentrations are higher in undernourished elderly subjects compared with the healthy elderly (345). Although circulating ghrelin concentrations increase between early adulthood and middle age in humans, there is evidence that old age is associated with decreased ghrelin concentrations in rodents and in humans (311, 346).…”

Section: Aging and Metabolismmentioning

confidence: 99%

Molecular Endocrinology and Physiology of the Aging Central Nervous System

2005

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Aging is associated with a progressive decline in physical and cognitive functions. The impact of age-dependent endocrine changes regulated by the central nervous system on the dynamics of neuronal behavior, neurodegeneration, cognition, biological rhythms, sexual behavior, and metabolism are reviewed. We also briefly review how functional deficits associated with increases in glucocorticoids and cytokines and declining production of sex steroids, GH, and IGF are likely exacerbated by age-dependent molecular misreading and alterations in components of signal transduction pathways and transcription factors. (Endocrine Reviews 26: 203-250, 2005)

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Postprandial Cholecystokinin Secretion in Elderly with Protein‐Energy Undernutrition

Abstract: The increase of postprandial maximal levels of cholecystokinin is more related to malnutrition than to aging.

Cited by 43 publications

References 31 publications

Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility

Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility

Ultrasonographic gastric emptying in protein energy malnutrition: effect of type of meal and nutritional recovery

Molecular Endocrinology and Physiology of the Aging Central Nervous System

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