Postprandial consequences of lipid absorption in the onset of obesity: Role of intestinal CD36

Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway

“…27 Moreover, it has been reported that the localization of CD36 on the cell membrane promotes the chylomicron formation by activating the ERK pathway. 34 Consistently, our data found that CLA decreased the chylomicron formation by inhibiting the ERK pathway. Besides that, the ERK pathway was involved in regulating the fatty acid uptake.…”

“…The CD36/ FYN/LYN complex could subsequently regulate the downstream intracellular signaling pathway such as the ERK signal-ing pathway, which has been proven to be involved in regulating the formation of chylomicrons in intestinal enterocytes. 34 Expectedly, we found that c9, t11-CLA inhibited the activation of the ERK pathway in the PA-treated MODE-K cells (Fig. 5B and C).…”

“…The localization of CD36 on the cell membrane can not only promote the uptake of FAs by intestinal epithelial cells, but also promote the chylomicron formation by activating the ERK (extracellular signal-regulated kinase) signaling pathway. 34 Besides, CD36 palmitoylation also participate in regulating intracellular signaling pathways. For instance, CD36 palmitoylation could promote inflammatory response in the liver cells of NAFLD (nonalcoholic fatty liver disease) patients by activating the JNK (c-Jun N-terminal kinase) signaling pathway.…”

Ultraprocessed plant‐based foods: Designing the next generation of healthy and sustainable alternatives to animal‐based foods

“…Regular and prolonged high blood sugar levels are linked to an increased risk of diabetes, overeating, and obesity due to their impact on insulin control, appetite, and other metabolic processes (Cai et al., 2021). Similarly, regular and prolonged high blood lipid levels have been linked to an increased risk of obesity and metabolic syndrome (Lebrun et al., 2022). It may therefore be advantageous to design UPB foods, so they are not rapidly digested within the GIT (or at least the starches and lipids are not digested rapidly).…”

Immediate-release niacin and a monounsaturated fatty acid-rich meal on postprandial inflammation and monocyte characteristics in men with metabolic syndrome

“…4 The postprandial hypertriglyceridemia is considered a metabolic condition with inflammatory consequences due to the transient increase of plasma proinflammatory biomarkers and to the defective immune response of circulating leukocytes in the period that follows a fatty meal. 5,6,7 Previous studies have reported that the predominant class of dietary fatty acids in the meals can play a role on postprandial metabolic factors associated with cardiovascular disease. Dietary monounsaturated fatty acids (MUFA) and omega-3 long-chain polyunsaturated fatty acids (PUFA) as compared to saturated fatty acids (SFA) have been found to be beneficial in terms of reducing atherogenic and diabetogenic disorders in healthy individuals and in individuals at risk of metabolic syndrome.…”