2022
DOI: 10.3389/fendo.2022.892677
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Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health

Abstract: IntroductionWhile oral glucose ingestion typically leads to a decrease in circulating glucagon levels, a substantial number of persons display stable or rising glucagon concentrations when assessed by radioimmunoassay (RIA). However, these assays show cross-reactivity to other proglucagon cleavage products. Recently, more specific assays became available, therefore we systematically assessed glucagon and other proglucagon cleavage products and their relation to metabolic health.Research Design and MethodsWe us… Show more

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“…above baseline) at the end of OGTT (i.e. 120 minutes) appears favorable as individuals were leaner, fasting glucagon and glucose levels were lower, insulin sensitivity higher and IGT risk was lower ( 20 , 64 ). In contrast to these adult studies, only a single subject in our study cohort, belonging to the NG-NW group, displayed a greater glucagon 120min concentration above baseline.…”
Section: Discussionmentioning
confidence: 99%
“…above baseline) at the end of OGTT (i.e. 120 minutes) appears favorable as individuals were leaner, fasting glucagon and glucose levels were lower, insulin sensitivity higher and IGT risk was lower ( 20 , 64 ). In contrast to these adult studies, only a single subject in our study cohort, belonging to the NG-NW group, displayed a greater glucagon 120min concentration above baseline.…”
Section: Discussionmentioning
confidence: 99%