Postprandial hypertriglyceridemia associated with inflammatory response and procoagulant state after a high-fat meal in hypertensive patients

Liu, Ling; Zhao, Shui‐Ping; Wen, Tie; Zhou, Hang; Hu, Min; Li, Jixiang

doi:10.1097/mca.0b013e3282f487f3

Cited by 14 publications

(8 citation statements)

References 35 publications

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“…Oxidative stress is also suggested to contribute to the postprandial inflammatory response through cytokine production [65,66]. Although IL-6 concentrations were elevated after meal ingestion, this change was equal between age groups.…”

Section: Discussionmentioning

confidence: 99%

Comparisons of the Postprandial Inflammatory and Endotoxaemic Responses to Mixed Meals in Young and Older Individuals: A Randomised Trial

et al. 2017

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Postprandial inflammation and endotoxaemia are determinants of cardiovascular and metabolic disease risk which are amplified by high fat meals. We aimed to examine the determinants of postprandial inflammation and endotoxaemia in older and younger adults following a high fat mixed meal. In a randomised cross-over trial, healthy participants aged 20–25 and 60–75 years (n = 15/group) consumed a high-fat breakfast and a low-fat breakfast. Plasma taken at baseline and post-meal for 5 h was analysed for circulating endotoxin, cytokines (monocyte chemotactic protein-1 (MCP-1), interleukin (IL)-1β, IL-6, and tumour necrosis factor-alpha (TNF-α)), lipopolysaccharide binding protein (LBP), and inflammatory gene expression in peripheral blood mononuclear cells (PBMC). Older subjects had lower baseline PBMC expression of glutathione peroxidase 1 (GPX-1) but greater insulin-like growth factor-binding protein 3 (IGFBP3) and circulating MCP-1 compared to younger subjects. After either meal, there were no age differences in plasma, chylomicron endotoxin, or plasma LBP concentrations, nor in inflammatory cytokine gene and protein expression (MCP-1, IL-1β, and TNF-α). Unlike younger participants, the older group had decreased superoxide dismutase (SOD)-2 expression after the meals. After a high-fat meal, older adults have no increased inflammatory or endotoxin response, but an altered oxidative stress gene response compared with younger adults. Healthy older adults, without apparent metabolic dysfunction, have a comparable postprandial inflammatory and endotoxaemia response to younger adults.

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Section: Discussionmentioning

confidence: 99%

Comparisons of the Postprandial Inflammatory and Endotoxaemic Responses to Mixed Meals in Young and Older Individuals: A Randomised Trial

et al. 2017

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“…Similarly, 10 g of oat husk for 2 weeks has been shown to decrease PAI-1 activity without any changes in fVII (Sundell and Ranby, 1993), and Landin et al (1992) found that 10 g of guar gum administered daily for 2 weeks decreased PAI-1 activity significantly (Landin et al, 1992). Increased postprandial fVII concentrations have been linked to lipid metabolism as it increases after intake of high-fat meals (Liu et al, 2008), and it is likely that the observed reduction in fVII and PAI-1 are linked, at least in part, to the decreased triacylglycerol concentrations observed in the present study. Previous studies have shown that oat bran can reduce postprandial plasma triacylglycerol responses (Cara et al, 1992;Dubois et al, 1995), and it is likely that a decreased postprandial lipemia, if occurring repeatedly over a 2-week period, may reduce not only fasting triacylglycerol concentrations but also PAI-1 activity and fVII concentrations.…”

Section: Discussionmentioning

confidence: 99%

A diet rich in oat bran improves blood lipids and hemostatic factors, and reduces apparent energy digestibility in young healthy volunteers

Kristensen

Bügel

2011

Eur J Clin Nutr

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Background/Objectives: Oat bran shows cholesterol-lowering properties, but its effects on other cardiovascular risk markers are less frequently investigated. This study examined the effects of oat bran on blood lipids, hemostatic factors and energy utilization. Subjects/Methods: A double-blind, randomized crossover study in 24 adults (age 25.2±2.7 years; body mass index: 24.9 ± 2.9 kg/m 2 ), who completed two 2-week dietary intervention periods: low-fiber diet (control) or an oat bran (control þ 102 g oat bran/day) diet. Fasting blood samples were drawn before and after each period, and 3-day fecal samples were collected during the last week of each period. Results: Total cholesterol decreased by 14% during the oat bran period compared with 4% during the control period (Po0.001). Non-high-density lipoprotein (HDL) cholesterol decreased by 16% in the oat bran period compared with 3% in the control period (Po0.01), as did total triacylglycerol (21 vs 10%, Po0.05) and very-low-density lipoprotein triacylglycerol 33 vs 9%, Po0.01). Plasminogen activator inhibitor-1 (PAI-1) and factor VII (fVII) levels decreased more during consumption of oat bran compared with the control period (PAI-1: 30 vs 2.3%, Po0.01; fVII: 15 vs 7.6%, o0.001). Fecal volume and dry matter were greater when consuming the oat bran diet compared with the control (Po0.001), and energy excretion was increased by 37% (1014 vs 638 kJ/day, Po0.001); however, changes in body weight did not differ (oat bran:À0.3 ± 0.5 kg; control: 0.0±0.7 kg). Conclusions: Addition of oat bran (6 g soluble fiber/day) to a low-fiber diet lowered total and non-HDL cholesterol, as well as hemostatic factors, and may affect energy balance through reduced energy utilization.

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“…Indeed, adoption of the Western dietary pattern results in frequent episodes of relatively pronounced postprandial lipaemia, and the magnitude of this response is emerging as an independent predictor of coronary heart disease risk, although the mechanisms underpinning this association remain to be defined . The question of whether or not dietary fat intake promotes systemic inflammation in man is therefore of much current interest, particularly as many groups have reported evidence of an increase in circulating inflammatory markers shortly after ingestion of a high‐fat meal in human volunteers .…”

Section: Introductionmentioning

confidence: 99%

High‐fat meal induced postprandial inflammation

Herieka

Erridge

2013

Molecular Nutrition Food Res

183

148

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Raised levels of circulating inflammatory markers are associated with coronary artery disease, obesity and type II diabetes. It has been proposed that the ingestion of high-fat meals may serve as a stimulus to raise systemic inflammatory tone, although interventional studies have yielded conflicting results. We here review 57 studies of high-fat meal induced acute postprandial inflammation to identify the most frequently reported markers of postprandial inflammation and to compare these results with the highly consistent low-grade endotoxaemia model in man. Most plasma borne markers of inflammation, such as cytokines and soluble adhesion molecules, were not consistently raised after a high-fat meal. However, pro-inflammatory leukocyte surface markers, mRNA and proteins were elevated in almost all studies in which they were measured. These markers followed kinetics similar to those observed following intravenous injection of low doses of endotoxin in man, were positively associated with likelihood of contamination of test meals with pro-inflammatory bacterial molecules and were reduced in several studies examining parallel meals supplemented with foodstuffs containing anti-inflammatory phytochemicals. Future studies of postprandial inflammation may yield more consistent evidence by focusing on leukocyte, rather than plasma-borne, markers of inflammation and by considering the test meal content of pro- and anti-inflammatory dietary constituents.

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Postprandial hypertriglyceridemia associated with inflammatory response and procoagulant state after a high-fat meal in hypertensive patients

Abstract: Postprandial hypertriglyceridemia in hypertensive patients is associated with inflammatory response and procoagulant state.

Cited by 14 publications

References 35 publications

Comparisons of the Postprandial Inflammatory and Endotoxaemic Responses to Mixed Meals in Young and Older Individuals: A Randomised Trial

Comparisons of the Postprandial Inflammatory and Endotoxaemic Responses to Mixed Meals in Young and Older Individuals: A Randomised Trial

A diet rich in oat bran improves blood lipids and hemostatic factors, and reduces apparent energy digestibility in young healthy volunteers

High‐fat meal induced postprandial inflammation

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