Postprandial impairment of flow-mediated dilation and elevated methylglyoxal after simple but not complex carbohydrate consumption in dogs

Adolphe, Jennifer L.; Drew, M. D.; Huang, Qian; Silver, Tawni I.; Weber, Lynn P.

doi:10.1016/j.nutres.2012.03.002

Cited by 44 publications

(50 citation statements)

References 52 publications

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“…A recent study in adult dogs investigated the effects of consumption of complex carbohydrates (barley, corn, peas and rice) supplemented at a daily dose of 10 g of available carbohydrate on glycemic response and cardiovascular health and oxidative stress markers [86]. Among the carbohydrate sources, peas had the lowest glycemic index value (29%) compared to barley and rice (51 and 55%, respectively, p < 0.05).…”

Section: Alternative Dietary Fiber Sources In Companion Animal Nutmentioning

confidence: 99%

Alternative Dietary Fiber Sources in Companion Animal Nutrition

2013

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The US has a pet population of approximately 70 million dogs and 74 million cats. Humans have developed a strong emotional bond with companion animals. As a consequence, pet owners seek ways to improve health, quality of life and longevity of their pets. Advances in canine and feline nutrition have contributed to improved longevity and well-being. Dietary fibers have gained renewed interest in the pet food industry, due to their important role in affecting laxation and stool quality. More recently, because of increased awareness of the beneficial effects of dietary fibers in health, as well as the popularity of functional foods and holistic and natural diets, alternative and novel carbohydrates have become widespread in human and pet nutrition. Fiber sources from cereal grains, whole grains and fruits have received increasing attention by the pet food industry and pet owners. While limited scientific information is available on the nutritional and nutraceutical properties of alternative fiber sources, studies indicate that corn fiber is an efficacious fiber source for pets, showing no detrimental effects on palatability or nutrient digestibility, while lowering the glycemic response in adult dogs. Fruit fiber and pomaces have good water-binding properties, which may be advantageous in wet pet food production, where a greater water content is required, along with low water activity and a firm texture of the final product. Rice bran is a palatable fiber source for dogs and may be an economical alternative to prebiotic supplementation of pet foods. However, it increases the dietary requirement of taurine in cats. Barley up to 40% in a dry extruded diet is well tolerated by adult dogs. In addition, consumption of complex carbohydrates has shown a protective effect on cardiovascular disease and oxidative stress. Alternative fiber sources are suitable ingredients for pet foods. They have been shown to be nutritionally adequate and to have potential nutraceutical properties.

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Section: Alternative Dietary Fiber Sources In Companion Animal Nutmentioning

confidence: 99%

Alternative Dietary Fiber Sources in Companion Animal Nutrition

2013

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“…There is ample experimental but also clinical evidence now that acute transient hyperglycemia may generate oxidative stress and endothelial dysfunction [2,12], ultimately resulting in impaired mitochondrial function, perturbed cellular metabolism and direct deoxyribonucleic acid (DNA) damage at the neuronal level [2]. A recent experimental study in dogs [13] has demonstrated that acute post-meal hyperglycemia may lead to reduced arterial flow-mediated dilatation along with increased serum methylglyoxal concentration. The latter is a highly reactive dicarbonyl intermediate metabolite of glucose that is recognized to induce oxidative stress [13,14].…”

Section: Pathogenesis: a Case For Postprandial Hyperglycemiamentioning

confidence: 99%

“…A recent experimental study in dogs [13] has demonstrated that acute post-meal hyperglycemia may lead to reduced arterial flow-mediated dilatation along with increased serum methylglyoxal concentration. The latter is a highly reactive dicarbonyl intermediate metabolite of glucose that is recognized to induce oxidative stress [13,14]. In another recent experimental work in mice, serum methylglyoxal has been demonstrated to be associated with diminished nerve conduction velocity, depolarization of sensory neurons and mechanical and thermal hyperalgesia [14].…”

Section: Pathogenesis: a Case For Postprandial Hyperglycemiamentioning

confidence: 99%

Polyneuropathy in Impaired Glucose Tolerance: Is Postprandial Hyperglycemia the Main Culprit? A Mini-Review

Παπάνας

Ziegler²

2012

Gerontology

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There is accumulating evidence for the mutual relationship between peripheral neuropathy and impaired glucose tolerance (IGT). The key factor in the pathogenesis of neuropathy in IGT is postprandial hyperglycemia, which induces increased oxidative stress, endothelial dysfunction, and activation of both protein kinase C and the polyol pathway, leading to impaired neuronal metabolism and DNA damage. Other pathogenic factors include dyslipidemia and the metabolic syndrome. The cornerstone of management is improved glycemic control, although a long sustainable effect has not been documented yet, calling for further supportive trials. Secondary therapeutic targets encompass hypolipidemic and antihypertensive treatment, smoking cessation and weight loss. The increasing awareness of peripheral neuropathy in IGT is expected to improve healthcare provision in subjects with this condition.

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“…Animal studies have shown that tissue levels of MG are strongly raised following high glycemic-index meals [16,17], hyperglycaemic episodes [18] and intake of high levels of fructose [19]. Furthermore, MG levels in erythrocytes from diabetic patients have been shown to be increased at least 15-fold compared to controls, possibly due to decreased glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity [20,21].…”

Section: Glycolysis Is a Risk Factormentioning

confidence: 99%

On the Relationship between Energy Metabolism, Proteostasis, Aging and Parkinson’s Disease: Possible Causative Role of Methylglyoxal and Alleviative Potential of Carnosine

Hipkiss¹

2017

Aging and disease

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Recent research shows that energy metabolism can strongly influence proteostasis and thereby affect onset of aging and related disease such as Parkinson’s disease (PD). Changes in glycolytic and proteolytic activities (influenced by diet and development) are suggested to synergistically create a self-reinforcing deleterious cycle via enhanced formation of triose phosphates (dihydroxyacetone-phosphate and glyceraldehyde-3-phosphate) and their decomposition product methylglyoxal (MG). It is proposed that triose phosphates and/or MG contribute to the development of PD and its attendant pathophysiological symptoms. MG can induce many of the macromolecular modifications (e.g. protein glycation) which characterise the aged-phenotype. MG can also react with dopamine to generate a salsolinol-like product, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinaline (ADTIQ), which accumulates in the Parkinson’s disease (PD) brain and whose effects on mitochondria, analogous to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), closely resemble changes associated with PD. MG can directly damage the intracellular proteolytic apparatus and modify proteins into non-degradable (cross-linked) forms. It is suggested that increased endogenous MG formation may result from either, or both, enhanced glycolytic activity and decreased proteolytic activity and contribute to the macromolecular changes associated with PD. Carnosine, a naturally-occurring dipeptide, may ameliorate MG-induced effects due, in part, to its carbonyl-scavenging activity. The possibility that ingestion of highly glycated proteins could also contribute to age-related brain dysfunction is briefly discussed.

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Postprandial impairment of flow-mediated dilation and elevated methylglyoxal after simple but not complex carbohydrate consumption in dogs

Cited by 44 publications

References 52 publications

Alternative Dietary Fiber Sources in Companion Animal Nutrition

Alternative Dietary Fiber Sources in Companion Animal Nutrition

Polyneuropathy in Impaired Glucose Tolerance: Is Postprandial Hyperglycemia the Main Culprit? A Mini-Review

On the Relationship between Energy Metabolism, Proteostasis, Aging and Parkinson’s Disease: Possible Causative Role of Methylglyoxal and Alleviative Potential of Carnosine

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