Postprandial lipaemia in patients with impaired fasting glucose, impaired glucose tolerance and diabetes mellitus

Objective: Postprandial (pp) lipid metabolism is associated with insulin resistance and type 2 diabetes. In young men, pp triglycerides (TGs) are more strongly associated with traits of metabolic syndrome (MS) than fasting TGs. We established a cohort of middle-aged men selected for traits of MS and pp lipid metabolism to determine if fasting TGs or pp TGs are more closely related to MS. Research design and methods: A total of 1558 men were characterized for MS. A total of 755 men underwent an oral metabolic tolerance test consisting of a standardized high-fat meal and an oral glucose tolerance test. Blood samples were drawn in the fasting state and hourly until 9 h to determine pp TGs and free fatty acids. Glucose and insulin were analyzed until 5 h pp. Results: In the overall cohort, 329 subjects (21.1%) had a complete MS based on the Adult Treatment Panel III criteria, and 650 subjects (41.7%) had a complete MS based on the International Diabetes Federation criteria. The association of pp TGs with MS parameters was not stronger than the association of fasting TGs with them. Pp TGs were independently associated with b-cell function. Conclusions: Pp TGs did not show a higher correlation with MS traits than fasting TGs. This finding is probably due to the high incidence of overweight subjects in this middle-aged cohort.

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“…This is in contrast to former small studies, which failed to show a difference in pp TGs between NGT and IGT/IFG (35,36).…”

Section: Discussioncontrasting

confidence: 54%

Association of postprandial and fasting triglycerides with traits of the metabolic syndrome in the Metabolic Intervention Cohort Kiel

Rubin¹,

Helwig

Nothnagel³

et al. 2010

European Journal of Endocrinology

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“…Specifically, delayed clearance of chylomicrons (CM) and their remnants increase the delivery of triglyceride and cholesteryl ester to the vessel wall and can accelerate the progression of atherosclerosis, which may be particularly pertinent to individuals with obesity and insulin resistance (Guerci et al, 2000). An exaggerated PPL response in both increment and duration is observed in both type 2 diabetes (T2DM) (Madhu et al, 2008) and obesity (Couillard et al, 1998;Guerci et al, 2000;van Wijk et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

et al. 2011

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Background/Objectives: Postprandial lipaemia is an established risk factor for atherosclerosis. To investigate the acute effect of four milk-derived dietary proteins (alpha-lactalbumin, whey isolate, caseinoglycomacropeptide and whey hydrolysate) on postprandial lipaemia, we have conducted a randomized, acute, single-blinded clinical intervention study with crossover design. Subjects/Methods: A total of 11 obese non-diabetic subjects (age: 44-74, BMI: 30-41.4 kg m -2 ) were included. On 4 different days the subjects ingested a high-fat meal with the following energy distribution: 66% energy from fat (100 g of butter), 15% of energy from carbohydrate (90 g of white wheat bread) and 19% of energy from protein (45 g of pure protein). Our primary variable was plasma triglyceride measured in the 8-h postprandial period. Secondarily, retinyl palmitate, non-esterified free fatty acids, glucose, insulin, glucagon, GLP-1 and GIP, active and total grehlin and cholecystokinin were measured. Results: We observed no statistically significant (P ¼ 0.8) differences between meals on our primary variable that is, triglycerides. Whey hydrolysate was associated with a significantly (P ¼ 0.02) smaller postprandial suppression of non-esterified free fatty acids compared with the other dietary proteins. Conclusion: We did not observe significant differences in postprandial lipaemia to the four milk-derived dietary proteins. Whey hydrolysate caused less postprandial suppression of free fatty acids.

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“…Postprandial TG response is influenced not only by diet composition 9) but also by the characteristics of the subjects, including gender 10) , genotypes 11) , age 12) , menopausal status 13) , glycemic status 14,15) , and visceral fat deposition 10,16) . In a previous work, we demonstrated that postprandial TG levels were significantly higher in men with impaired glucose tolerance (IGT) than in those with normal glucose tolerance (NGT) 15) ;…”

mentioning

confidence: 99%

Difference between Fasting and Nonfasting Triglyceridemia; the Influence of Waist Circumference

Oka

Kobayashi

Miura

et al. 2009

JAT

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Postprandial lipaemia in patients with impaired fasting glucose, impaired glucose tolerance and diabetes mellitus

Cited by 23 publications

References 33 publications

Association of postprandial and fasting triglycerides with traits of the metabolic syndrome in the Metabolic Intervention Cohort Kiel

Association of postprandial and fasting triglycerides with traits of the metabolic syndrome in the Metabolic Intervention Cohort Kiel

Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

Difference between Fasting and Nonfasting Triglyceridemia; the Influence of Waist Circumference

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