Postprandial Lipemic Response Is Modified by the Polymorphism at Codon 54 of the Fatty Acid–Binding Protein 2 Gene

Abstract

Abstract-Polymorphism of the fatty acid-binding protein 2 (FABP2) gene has been shown to affect the affinity of intestinal FABP for fatty acids. This could cause changes in postprandial triglyceride metabolism. In the present study, postprandial lipemia was studied in normotriglyceridemic subjects with genetic variation in the FABP2 gene. Oral fat-loading tests were performed in 8 subjects homozygous for the Thr-encoding allele at codon 54 of the FABP2 gene and in 7 subjects homozygous for the Ala-encoding allele (wild type). There were no significant differences between these 2 groups in age, body mass index, fasting plasma triglyceride and cholesterol levels, or fasting glucose and insulin levels. With reservations related to a small number of subjects studied, these results indicate that the Thr-encoding allele of the FABP2 gene is associated with increased postprandial lipemia. The lipemic response was associated with postprandial insulin response, suggesting that in the Thr-54 homozygotes, altered postprandial lipemia may also modify insulin action or vice versa.

Association of the Ala54-thr Polymorphism in the Intestinal Fatty Acid–Binding Protein With 2-h Postchallenge Insulin Levels in the Framingham Offspring Study

“…In addition, there was no significant difference between ala54 homozygotes and thr54 homozygotes in fasting insulin levels or the response of plasma insulin to an oral fat load in a Finnish population or in participants of the European Atherosclerosis Study (43,44). However, there was a strong correlation in the Finnish study between TG and insulin responses in thr54 homozygotes, suggesting an association between postprandial triglyceridemia and insulin action in these subjects (43).…”

“…However, there was a strong correlation in the Finnish study between TG and insulin responses in thr54 homozygotes, suggesting an association between postprandial triglyceridemia and insulin action in these subjects (43). In a group of Pima Indians, plasma 1-h insulin levels and nonesterified fatty acid levels were higher after a high-fat test meal in thr54 homozygotes than in ala54 homozygotes (45).…”

Thr-encoding Allele Homozygosity at Codon 54 of FABP 2 Gene May be Associated with Impaired Delta 6 Desatruase Activity and Reduced Plasma Arachidonic Acid in Obese Children

“…Intestinal FABP (I-FABP) encoded by the FABP 2 al lipemic response 6,7) , which may be caused by the altered amount of absorbed FA 8) and increased trafficking of fatty acids to chylomicron assembly 9) . In contrast, reports in other human populations did not confirm the role of Thr54 in lipid and glucose metabolism [10][11][12] .…”

Analyse génotypique de gènes de susceptibilité à l'obésité au sein d'une cohorte de travailleurs forestiers de la compagnie Abitibi Consolotidated de Saint-Félicien /

“…Bien que l'allèle 54T ait déjà été associé avec des concentrations élevées de triglycérides, aucune association à ce niveau n'a été détectée dans la présente étude. Cependant, cette hypothèse est peu probable puisque le polymorphisme A54T n'est pas un marqueur silencieux et ceci est maintenant très bien défini (Baier et al, 1996;Agren et al, 1998). Nos résultats devraient être confirmés dans une plus grande cohorte avant de conclure sur un réel rôle protecteur du variant A54T.…”