Postprandial Responses of Liver Blood Flow Prior to and Following Hepatectomy in Conscious Dogs

Kameoka, Nobuki; Nimura, Yuji; Sato, Tatsuro; Kato, Masataka; Yasui, Akihiro; Kondo, Satoshi

doi:10.1006/jsre.1996.0142

Cited by 8 publications

(7 citation statements)

References 12 publications

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“…Interestingly, in one unsedated dog, mean PF velocity was reduced at 7 cm/s the first day (preprandially) and reversed the following day (postprandially). Postprandial increase in PF, which was documented in dogs, 54 may have caused the portosystemic collaterals to become functional. Hepatofugal PF appears to be highly specific for portosystemic shunting in dogs and probably cats.…”

Section: Discussionmentioning

confidence: 94%

“…Additionally, the impact of a meal and of sedation or anesthesia on PF measurements has been documented in dogs and humans 54,56 . PF increases postprandially in dogs, 54,56 decreases under general anesthesia using isoflurane or halothane, 57 but appears unaffected by Propofol 58 . The impact of sedation with a combination of butorphanol, acepromazine, and glycopyrrolate on the PF is unknown.…”

Section: Discussionmentioning

confidence: 99%

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Ultrasonographic Diagnosis of Portosystemic Shunting in Dogs and Cats

d’Anjou

Penninck

Cornejo

et al. 2004

Vet Radiology Ultrasound

128

145

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The value of ultrasonography was evaluated in 85 dogs and 17 cats presented with a clinically suspected portosystemic shunt (PSS). A PSS was confirmed in 50 dogs and nine cats (single congenital extrahepatic in 42, single congenital intrahepatic in 11, and multiple acquired in six). Six dogs and one cat had hepatic microvascular dysplasia, and 29 dogs and seven cats had a normal portal system. Ultrasonography was 92% sensitive, 98% specific, and had positive and negative predictive values of 98% and 89%, respectively, in identifying PSS, with an overall accuracy of 95%. When a PSS was identified with ultrasonography, extrahepatic, intrahepatic, and multiple acquired PSS could be correctly differentiated in 53/54 patients (98%). The combination of a small liver, large kidneys, and uroliths had positive and negative predictive values of 100% and 51% for the presence of a congenital PSS in dogs. The portal vein/aorta (PV/Ao) and portal vein/caudal vena cava (PV/ CVC) ratios were smaller in animals with extrahepatic PSSs compared with animals with microvascular dysplasia, intrahepatic PSSs and those without portal venous anomalies (P<0.001). All dogs and cats with a PV/Ao ratio of < or = 0.65 had an extrahepatic PSS or idiopathic noncirrhotic portal hypertension. Dogs and cats with PV/Ao and PV/CVC ratios of > or = 0.8 and > or = 0.75, respectively, did not have an extrahepatic PSS. Reduced or reversed portal flow was seen in four of four patients with multiple acquired PSSs secondary to portal hypertension. The presence of turbulence in the caudal vena cava of dogs had positive and negative predictive values of 91% and 84%, respectively, for the presence of any PSS terminating into that vein.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Diagnosis of Portosystemic Shunting in Dogs and Cats

d’Anjou

Penninck

Cornejo

et al. 2004

Vet Radiology Ultrasound

128

145

View full text Add to dashboard Cite

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“…Firstly, the difference between moderate and high CL and between moderate and low CL is smaller (less than two-fold) and therefore they may be more difficult to distinguish experimentally. Also, liver blood flow itself is subject to variability within species (Kameoka et al 1996) and different test centres are likely to have different estimates of liver blood flow (Kurosawa et al 2002). To the extent that protein binding and CL i measurements are useful generally in understanding and predicting pharmacokinetic behaviour, their utility was expected to be enhanced at these extremes.…”

Section: Discussionmentioning

confidence: 99%

Differences in the total body clearance of lead compounds in the rat and mouse: Impact on pharmacokinetic screening strategy

et al. 2008

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1. The in vivo clearance (CL) for 498 compounds representing more than 40 lead optimization programmes were compared in the rat and mouse. 2. A total of 278 of the compounds had similar CL values in rat and mouse and 41 compounds had a high CL in one rodent species and a low CL in the other (median seven-fold difference). For this latter subset, comparative in vitro plasma protein binding, liver microsomal or hepatocyte intrinsic CL provided plausible explanations for the observed in vivo differences in many cases. 3. A considerable proportion of compounds with substantially different CL in rodents, and those with a high CL in both rat and mouse, had a low-to-moderate CL in dog and/or monkey (43%). A larger proportion (71%) had promising pharmacokinetics in higher species when CL was low in both rat and mouse. 4. Drug-discovery scientists should consider the potential for there to be substantial differences in the disposition of leads in different rodent species and design screening cascades to explore this possibility.

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“…[32][33][34][35][36][37][58][59][60][61][62][63][64][65][66][67] Hemodynamic studies on the perioperative condition of the cholestatic liver have also contributed to safer management of surgical patients. [68][69][70][71][72][73][74][75] Major liver resection with extended autonomic nerve and lymph node dissection has been performed in Nagoya University Hospital to overcome bile duct carcinoma with perineural invasion, which is an inherent characteristic and major prognostic factor of biliopancreatic cancers, 76,77 and we have emphasized here some benefits of this type of surgery. However, not only the advantages but also the hazards of the extended surgery should be carefully evaluated by both Eastern and Western surgeons because autonomic nerve dissection may confer some unknown effects on the surgical patients.…”

Section: Discussionmentioning

confidence: 99%

Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience

Nimura

Kamiya

Kondo

et al. 2000

Journal of Hepato-Biliary-Pancreatic Surgery

Self Cite

364

298

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From 1977 to 1997, surgical resection was possible in 142 (80%) of 177 patients with hilar cholangiocarcinoma after relieving jaundice by single or multiple percutaneous transhepatic biliary drainage followed by percutaneous transhepatic cholangioscopy and/or percutaneous trans-hepatic portal vein embolization. Curative resection was possible in 108 (61%) of the 142 patients, and 100 of these patients underwent various types of hepatectomy with caudate lobectomy for a 30-day operative mortality rate of 6% and 9% hospital mortality. Combined portal vein resection was carried out in 43 cases including 41 hepatectomies and 2 bile duct resections. Hepatopancreatoduodenectomy was performed in 16 patients. Cancer recurrence was observed in 58 of the 108 patients undergoing curative resection. The 3-, 5-, and 10-year survival rates for 100 patients undergoing curative hepatectomy and 8 with curative bile duct resection were 43%, 26%, and 19%; and 31%, 16%, and 0%, respectively; those for 40 patients with positive lymph node metastasis, 84 with perineural invasion, and 43 with combined portal vein resection were 27%, 14%, and 7%; 34%, 21%, and 13%; and 18%, 6%, and 0%, respectively. These survival rates are significantly better than those for 35 patients with unresectable cancer. Curative resection after aggressive preoperative management is recommended as a reasonable surgical approach to hilar cholangiocarcinoma.

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Postprandial Responses of Liver Blood Flow Prior to and Following Hepatectomy in Conscious Dogs

Cited by 8 publications

References 12 publications

Ultrasonographic Diagnosis of Portosystemic Shunting in Dogs and Cats

Ultrasonographic Diagnosis of Portosystemic Shunting in Dogs and Cats

Differences in the total body clearance of lead compounds in the rat and mouse: Impact on pharmacokinetic screening strategy

Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience

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