Postprandial Triacylglycerol Responses in Simulated Night and Day Shift: Gender Differences

Sopowski, M. J.; Hampton, Shelagh M.; Ribeiro, D. C. O.; Arendt, Joséphine

doi:10.1177/074873040101600310

Cited by 12 publications

(17 citation statements)

References 25 publications

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“…These factors are all considered as risk factors for body weight gain and the onset of the metabolic syndrome, type 2 diabetes, and cardiovascular diseases (19,53,56). Interestingly, Sopowoski et al (57) found that men have higher and longer elevated triacylglycerol levels compared to women in response to eating at night. These findings could mean that women have lower risk to gain weight as a result of night work compared to men.…”

Section: Explanation Of the Findingsmentioning

confidence: 99%

The effects of shift work on body weight change − a systematic review of longitudinal studies

Drongelen¹,

Boot²,

Merkus³

et al. 2011

Scand J Work Environ Health

162

151

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Section: Explanation Of the Findingsmentioning

confidence: 99%

The effects of shift work on body weight change − a systematic review of longitudinal studies

Drongelen¹,

Boot²,

Merkus³

et al. 2011

Scand J Work Environ Health

162

151

View full text Add to dashboard Cite

“…In the last decade, epidemiological studies have documented that postprandial TG concentrations are correlated with the incidence of cardiovascular events, suggesting that postprandial plasma TGs are a good marker for the risk of cardiovascular disease (Miller et al 2011). In humans, postprandial TG responses vary during the day, being higher during the resting phase than during the active phase (Romon et al 1997;Sopowski & Hampton, 2001), suggesting the involvement of the SCN or behavioural activity. Moreover, epidemiological studies show that night workers, who have activity and meal patterns shifted towards the night, have an increased risk for cardiovascular diseases (Gu et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The suprachiasmatic nucleus drives day–night variations in postprandial triglyceride uptake into skeletal muscle and brown adipose tissue

Morán-Ramos

Guerrero‐Vargas

Méndez‐Hernández

et al. 2017

Experimental Physiology

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What is the central question of this study? What are the factors influencing day-night variations in postprandial triglycerides? What is the main finding and its importance? Rats show low postprandial plasma triglyceride concentrations early in the active period that are attributable to a higher uptake by skeletal muscle and brown adipose tissue. We show that these day-night variations in uptake are driven by the suprachiasmatic nucleus, probably via a Rev-erbα-mediated mechanism and independent of locomotor activity. These findings highlight that the suprachiasmatic nucleus has a major role in day-night variations in plasma triglycerides and that disturbances in our biological clock might be an important risk factor contributing to development of postprandial hyperlipidaemia. Energy metabolism follows a diurnal pattern, mainly driven by the suprachiasmatic nucleus (SCN), and disruption of circadian regulation has been linked to metabolic abnormalities. Indeed, epidemiological evidence shows that night work is a risk factor for cardiovascular disease, and postprandial hyperlipidaemia is an important contributor. Therefore, the aim of this work was to investigate the factors that drive day-night variations in postprandial triglycerides (TGs). Intact and SCN-lesioned male Wistar rats were subjected to an oral fat challenge during the beginning of the rest phase (day) or the beginning of the active phase (night). The plasma TG profile was evaluated and tissue TG uptake assayed. After the fat challenge, intact rats showed lower postprandial plasma TG concentrations early in the night when compared with the day. However, no differences were observed in the rate of intestinal TG secretion between day and night. Instead, there was a higher uptake of TG by skeletal muscle and brown adipose tissue early in the active phase (night) when compared with the rest phase (day), and these variations were abolished in rats bearing bilateral SCN lesions. Rev-erbα gene expression suggests this as a possible mediator of the mechanism linking the SCN and day-night variations in TG uptake. These findings show that the SCN has a major role in day-night variations in plasma TGs by promoting TG uptake into skeletal muscle and brown adipose tissue. Consequently, disturbance of the biological clock might be an important risk factor contributing to the development of hyperlipidaemia.

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“…Of the 5 studies included, 3 were conducted in men. Two studies included both males and females, of which one aimed to investigate sex-differences in postprandial TAG (Sopowski et al, 2001). Sample size ranged from 9 to 25; this results in a combined total of 73 participants, of which most were male ( n = 61).…”

Section: Resultsmentioning

confidence: 99%

Effect of Night Time Eating on Postprandial Triglyceride Metabolism in Healthy Adults: A Systematic Literature Review

et al. 2019

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Eating at night time, as is frequent in shift workers, may contribute to increased cardiovascular disease (CVD) risk through a disruption in usual lipid metabolism, resulting in repeated and sustained hyperlipidemia at night. This systematic review aimed to investigate the impact of eating a meal at night compared with the same meal eaten during the day on postprandial lipemia. Six databases were searched: CINAHL Plus, Cochrane Library, EMBASE, Ovid MEDLINE, Informit, and SCOPUS. Eligible studies were original research cross-over design with a minimum fasting period of 5 h before testing preceded by a standardized control meal; measured postprandial triacylglycerol (TAG) for 5 h or greater; had meal time between 0700 h and 1600 h for day time and between 2000 h and 0400 h for night time; and had within-study test meals (food or drink) that were identical in macronutrient composition and energy. Two authors independently completed eligibility and quality assessment using the American Dietetic Association Quality Criteria Checklist for Primary Research. After removing duplicates, 4,423 articles were screened, yielding 5 studies for qualitative synthesis. All studies identified at least one parameter of the postprandial TAG response that was different as a result of meal time (e.g., the total concentration or the time course kinetics). Two studies reported a greater total TAG concentration (area under curve) at night compared with day, and 3 studies found no difference. Four studies reported that the kinetics of the postprandial time course of TAGs was different at night compared with during the day. Inconsistent reporting in the primary studies was a limitation of the review. Night eating may negatively affect postprandial lipemia and this review shows there is a need to rigorously test this using standardized methods and analysis with larger sample sizes. This is critical for informing strategies to lower CVD risk for shift workers.

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Postprandial Triacylglycerol Responses in Simulated Night and Day Shift: Gender Differences

Cited by 12 publications

References 25 publications

The effects of shift work on body weight change − a systematic review of longitudinal studies

The effects of shift work on body weight change − a systematic review of longitudinal studies

The suprachiasmatic nucleus drives day–night variations in postprandial triglyceride uptake into skeletal muscle and brown adipose tissue

Effect of Night Time Eating on Postprandial Triglyceride Metabolism in Healthy Adults: A Systematic Literature Review

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