More than 10 million Americans misused prescription opioids in 2019. 1 Prescription drug misuse is second only to marijuana use as the nation's most commonly used illicit drug. 2 From 1999 to 2019, almost half a million people have died from overdoses involving opioids 3 ; of note, the mortality rate in 2019 was more than six times higher than in 1999. 3 Further, we know that almost half of opioid overdose deaths involve prescription opioids. 4 Almost all of us have either