Postradiation osteogenic sarcoma of bone and soft tissues. A clinicopathologic study of 66 patients

Huvos, Andrew G.; Woodard, Helen Q.; Cahan, William G.; Higinbotham, Norman L.; Stewart, Fred W.; Butler, Avital; Bretsky, Sara S.

doi:10.1002/1097-0142(19850315)55:6<1244::aid-cncr2820550617>3.0.co;2-1

Cited by 307 publications

(149 citation statements)

References 38 publications

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“…The most common histological subtypes are osteosarcoma and malignant fi brous histiocytoma, although other histologies (e.g., angiosarcoma, rhabdomyosarcoma) can occur. It is estimated that the risk of developing osteosarcoma in irradiated bone is 0.03-0.8 % (Kalra et al 2007 ;Huvos et al 1985 ;Koshurnikova et al 2000 ;Arlen et al 1971 ;Mark et al 1994 ;Enneking et al 1980 ;Kaplan and Meier 1958 ;Nakanishi et al 1998 ;Mertens et al 2000 ).…”

Section: Malignant Tumorssupporting

confidence: 91%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Medical Radiology-Diagnostic Imaging is a unique series that aims to document the most innovative technologies in all fi elds within diagnostic imaging and interventional radiology, thereby informing the physician in practice of the latest advances in diagnostic imaging and percutaneous imageguided minimally invasive procedures. Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest advances in diagnostic and treatment techniques. Th e contents range from contemporary statements relating to management for various disease sites to explanations of the newest techniques for tumor identifi cation and of mechanisms for the enhancement of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. AbstractA precise knowledge of antineoplastic drugs is an indispensable basis for the care of patients with cancer. The mechanisms of action and resistance, cross-resistance patterns, pharmacodynamics and pharmacokinetics, pharmacological interaction, and last but not least potential adverse effects should be part of this knowledge. As contemporary cancer care requires interdisciplinary and multiprofessional structures, the radiologist is an important a...

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Section: Malignant Tumorssupporting

confidence: 91%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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“…RIS is a serious long-term side effect of radiotherapy, and it is important to assess its significance [18]. The current single institution series is one of the largest reported, and our finding that 3.0% of all sarcomas in the NRH database are RIS, is in agreement with the literature [6,7]. The carcinogenicity of ionizing radiation is partly related to genotoxic stress which can induce sublethal DNA damage, including DNA double-strand breakinduced gene translocation, genomic instability and loss of DNA repair [19].…”

Section: Discussionmentioning

confidence: 99%

Radiation-induced sarcoma: 25-year experience from The Norwegian Radium Hospital

et al. 2008

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“…The efficacy of multidrug chemotherapy for patients with primary osteosarcoma of long bones amenable to en bloc resection is well documented (Huvos et al, 1985;Link et al, 1986;Eilber et al, 1987;Saeter et al, 1991;Meyers et al, 1992;Meyer et al, 2001). Kellie et al (1990) advocate the use of preoperative multiagent chemotherapy to facilitate surgical resection of non-Ewing's sarcomas of flat bone.…”

Section: Discussionmentioning

confidence: 99%

“…With the exception of Ewing's sarcoma, other primary flat bone sarcomas (osteosarcoma, malignant fibrous histiocytoma and chondrosarcoma) are rare in children and adolescents, and their incidence increases with advancing age (Boland and Huvos, 1986;Goorin et al, 1987;Huvos and Marcove, 1987;Tucker et al, 1987;Young et al, 1990). In contrast, bone sarcoma occurring as a second malignant neoplasm after irradiation is more likely to arise in flat bones of the axial skeleton than are de novo bone sarcomas (Weatherby et al, 1981;Huvos et al, 1985;Stea et al, 1987;Pratt et al, 1997;Tabone et al, 1999).…”

mentioning

confidence: 99%

Outcome of flat bone sarcomas (other than Ewing's) in children and adolescents: a study of 25 cases

Minard‐Colin

Kalifa

et al. 2004

Br J Cancer

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We analysed the clinical features and outcome of young patients with non-Ewing's flat bone sarcoma treated during the era of contemporary chemotherapy. The characteristics and outcome of 25 patients (15 males and 10 females) with primary or radiationrelated flat bone sarcoma treated in the Pediatrics Department at the Institut Gustave Roussy from 1981 to 1999 were reviewed. In all, 20 patients had osteosarcoma, four chondrosarcoma and one malignant fibrous histiocytoma. The age at diagnosis ranged from 2 to 23 years (median, 15 years). Nine tumours were located in the craniofacial bones, 11 in the pelvis and five in flat bones at other sites. Four patients had metastatic disease at diagnosis. Radiation-associated flat bone osteosarcoma was diagnosed in 10 out of 25 cases. The projected overall survival and event-free survival (EFS) rates at 5 years were 45.1 and 34.3% for all the 25 patients. The EFS rate of patients with second bone sarcoma was similar to that of patients with de novo flat bone sarcoma (P ¼ 0.1). The aim of treatment was curative for 24 patients, 23 of whom were treated with intensive chemotherapy regimens and 19 with surgery. Significant adverse prognostic factors on survival included incomplete surgical resection (P ¼ 0.001) and use of regimens without preand postoperative chemotherapy (P ¼ 0.007). Nine of the 25 patients were treated with pre-and postoperative chemotherapy and complete surgical resection. Among them, eight are alive with no disease. Radical surgical resection is the overriding prognostic factor for flat bone sarcomas in young patients. Nevertheless, our results suggest a more favourable outcome since the advent of intensive chemotherapy.

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Postradiation osteogenic sarcoma of bone and soft tissues. A clinicopathologic study of 66 patients

Cited by 307 publications

References 38 publications

Female Pelvis: Genital Organs

Female Pelvis: Genital Organs

Radiation-induced sarcoma: 25-year experience from The Norwegian Radium Hospital

Outcome of flat bone sarcomas (other than Ewing's) in children and adolescents: a study of 25 cases

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