Studying human activities requires an examination of the inherent epistemological problems in building arguments about the past based on chemical residues and modern observations. A reflexive approach to the analysis of chemical residues at the San Lucas archaeological site, a Classic Hohokam settlement located in Marana, Arizona, represents a unique opportunity to evaluate current techniques and paradigms for the interpretation of daily life activities. By incorporating an innovative program rooted in satellite remote sensing image analysis and spatial statistics, including new techniques, such as bulk density, loss on ignition, electrical conductivity, and salinity, results suggest that soil chemical analysis will benefit more from learning about structure and agency than from one single activity.