Poststeroid Panniculitis in an Adult

de-Andrés-del-Rosario, Ana; Verea-Hernando, M. M.; Yebra‐Pimentel, María Teresa; Rosende‐Maceiras, Laura; Piñeyro-Molina, F.; Fonseca, Eduardo

doi:10.1097/dad.0b013e318217a97d

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…They can appear with pancreatic disease, rheumatoid arthritis, α 1 ‐antitrypsin deficiency, infections, id reactions, myeloid disorders, trauma and factitial disease . Drug‐induced panniculitis is an uncommon event that has been reported with a variety of medications including systemic steroids, filgrastim, vemurafenib and other kinase inhibitors . The diagnosis is based on clinical as well as histopathologic findings, which typically show an acute inflammatory infiltrate predominantly in the lobules that can also extend into the fibrous septae and dermis.…”

Section: Discussionmentioning

confidence: 99%

Ponatinib‐induced neutrophilic panniculitis

et al. 2014

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Ponatinib is a bcr-abl tyrosine-kinase inhibitor (TKI) used to treat resistant and refractory chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia that express bcr-abl. Neutrophilic panniculitis has been described in rare cases of patients on other TKIs in the same class as ponatinib. We present the first case of neutrophilic panniculitis following treatment with ponatinib and summarize the other cases of panniculitis caused by TKIs.

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Section: Discussionmentioning

confidence: 99%

Ponatinib‐induced neutrophilic panniculitis

et al. 2014

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Panniculitis

Requena

2016

Rook's Textbook of Dermatology, Ninth Edition

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The panniculitides comprise a group of heterogeneous inflammatory diseases that involve the subcutaneous fat. Histopathological study is required for the specific diagnosis of these disorders, because different panniculitides usually show the same clinical appearance – which typically consists of erythematous nodules on the lower extremities. However, the histopathological study of panniculitis is difficult because of the poor correlation between clinical and pathological findings and the changing microscopic appearances as the lesions evolve. Furthermore, large scalpel incisional biopsies are required in order to evaluate panniculitis fully. From the histopathological point of view, all panniculitides are somewhat mixed, because the inflammatory infiltrate involves both the septa and lobules. However, differentiation between a predominantly septal and a predominantly lobular panniculitis is usually straightforward at scanning magnification on the basis of which subcutaneous structures are the more intensely involved by the inflammatory infiltrate.

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Panniculitis

Requena,

Cerroni

2024

Rook's Textbook of Dermatology

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The panniculitides represent a group of heterogeneous inflammatory diseases that involve the subcutaneous fat. The specific diagnosis of these disorders requires histopathological study because different panniculitides usually show monotonous clinical appearance, namely subcutaneous erythematous nodules on the lower extremities. Histopathological study of panniculitis is also challenging because of an inadequate clinicopathological correlation and the evolutionary nature of the lesions. Often, biopsy specimens are taken from late‐stage lesions, which results in non‐specific histopathological findings. In addition, large‐scalpel incisional biopsies are required. However, with adequate biopsy samples a histopathological differential diagnosis between a mostly septal and a mostly lobular panniculitis is straightforward and with adequate clinicopathological correlation, a specific diagnosis may be rendered in most cases of panniculitis. Mostly septal panniculitides with vasculitis include superficial thrombophlebitis and cutaneous polyarteritis nodosa (cutaneous arteritis). Septal panniculitides with no vasculitis may appear as the consequence of dermal inflammatory processes extending to the subcutaneous fat, such as necrobiosis lipoidica, scleroderma, subcutaneous granuloma annulare, rheumatoid nodule and necrobiotic xanthogranuloma, whereas in other cases the inflammatory process involves primarily the connective tissue septa of the subcutis with no participation of the overlying dermis. The most frequent septal panniculitis is erythema nodosum. In contrast, the most common lobular panniculitis with vasculitis is erythema induratum of Bazin (nodular vasculitis). Mostly lobular panniculitides without vasculitis comprise a large list of disorders, including sclerosing panniculitis (lipodermatosclerosis), subcutaneous fat necrosis of the newborn, panniculitis associated with connective tissue diseases, pancreatic panniculitis, 1 ‐antitrypsin deficiency‐associated panniculitis, infective panniculitis and factitious panniculitis. In recent years, several cases of both septal and lobular panniculitis have been described as a consequence of the administration of new drugs, including immune checkpoint inhibitors and BRAF inhibitors used as treatment of metastatic melanoma, tyrosine kinase and Bruton tyrosine kinase inhibitors used for treatment of leukemia and other haematological malignancies and tumour necrosis factor inhibitor drugs.

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Poststeroid Panniculitis in an Adult

Cited by 7 publications

References 14 publications

Ponatinib‐induced neutrophilic panniculitis

Ponatinib‐induced neutrophilic panniculitis

Panniculitis

Panniculitis

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