Poststreptococcal reactive arthritis.

Arnold, Mark; Tyndall, A

doi:10.1136/ard.48.8.686

Cited by 49 publications

(14 citation statements)

References 12 publications

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“…What is at issue is whether to recognize PSRA as a separate disease from the polyarthritis clearly associated with RF [57,58]. The characteristics of PSRA that are not typical of ARF are persistence of arthritis for several months, nonmigratory polyarthritis, poor response to NSAIDs, and, in adults, an apparent predilection for female patients.…”

Section: Problematic Isolated Major Manifestationsmentioning

confidence: 96%

Rheumatic Fever in the 21st Century

Stollerman

2001

CLIN INFECT DIS

139

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In the first half of the twentieth century, the group A streptococcus (GAS) was established as the sole etiologic agent of acute rheumatic fever (ARF). In the century's latter half, the clinical importance of variation in the virulence of strains of GAS has become clearer. Although still obscure, the pathogenesis of ARF requires primary infection of the throat by highly virulent GAS strains. These contain very large hyaluronate capsules and M protein molecules. The latter contain epitopes that are cross-reactive with host tissues and also contain superantigenic toxic moieties. In settings where ARF has become rare, GAS pharyngitis continues to be common, although it is caused by GAS strains of relatively lower virulence. These strains, however, colonize the throat avidly and stubbornly. Molecularly distinct pyoderma strains may cause acute glomerulonephritis, but they are not rheumatogenic, even though they may secondarily colonize and infect the throat. Guidelines for the diagnosis, treatment, and prevention of GAS pharyngitis and ARF are reviewed with particular reference to the prevalence of the latter in the community.

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Section: Problematic Isolated Major Manifestationsmentioning

confidence: 96%

Rheumatic Fever in the 21st Century

Stollerman

2001

CLIN INFECT DIS

139

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“…Arthritis following primary throat infection with ␤HSA applies to this definition. Recent papers suggest that a spectrum of reactive post-streptococcal diseases may become manifest secondary to ␤HSA infection [3][4][5][6][7][8][9]. Though arthritis may be very painful in post-streptococcal disease, the complication which is most feared in ARF is a devastating carditis.…”

Section: Introductionmentioning

confidence: 99%

Post‐streptococcal reactive arthritis: a clinical and serological description, revealing its distinction from acute rheumatic fever

Jansen¹,

Janssen

Jong

et al. 1999

Journal of Internal Medicine

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“…In contrast with these studies, other researchers report an increased frequency of HLA-DR4 and HLA-DR2 among white and black patients with rheumatic heart disease [36]. Other studies have implicated DR1 and DRW6 as susceptibility factors in South African black patients with rheumatic heart disease [37].…”

Section: Geneticsmentioning

confidence: 94%

Immunogenic and genetic factors in rheumatic fever

Carreño-Manjarrez

Visvanathan

Zabriskie

2000

Curr Infect Dis Rep

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Although rheumatic fever has virtually disappeared in many developed countries, it remains the number one acquired heart disease among children in developing countries. Many hypotheses advanced to explain the pathogenic mechanisms of this disease include the concept of an abnormal humoral and cellular response within the host to streptococcal antigens cross-reacting with mammalian tissues. This report examines the most recent evidence supporting this concept. It emphasizes the importance of the cellular arm of the immune response in cardiac damage, as wall as possible genetic disposition to the disease.

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Poststreptococcal reactive arthritis.

Cited by 49 publications

References 12 publications

Rheumatic Fever in the 21st Century

Rheumatic Fever in the 21st Century

Post‐streptococcal reactive arthritis: a clinical and serological description, revealing its distinction from acute rheumatic fever

Immunogenic and genetic factors in rheumatic fever

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