Poststroke fatigue is associated with caudate infarcts

Tang, Wai Kwong; Liang, Huajun; Chen, Y.K.; Chu, Winnie C.W.; Abrigo, Jill; Mok, Vincent; Ungvári, Gábor S.; Wong, Ka Sing

doi:10.1016/j.jns.2012.10.022

Cited by 55 publications

(70 citation statements)

References 38 publications

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“…He was depressed and mildly apathetic showing reduced communication in activities of daily living. He also felt tired and developed right fronto-parietal headache soon after starting aphasia testing or therapy, a set of symptoms resembling the ones reported in patients with minor strokes in either left parietal, thalamic or caudate regions (Staub and Bogousslavsky, 2001; Radman et al, 2012; Tang et al, 2013). …”

Section: Methodsmentioning

confidence: 68%

Dissociated repetition deficits in aphasia can reflect flexible interactions between left dorsal and ventral streams and gender-dimorphic architecture of the right dorsal stream

Berthier

Dávila

Nabrozidis

et al. 2013

Front. Hum. Neurosci.

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Assessment of brain-damaged subjects presenting with dissociated repetition deficits after selective injury to either the left dorsal or ventral auditory pathways can provide further insight on their respective roles in verbal repetition. We evaluated repetition performance and its neural correlates using multimodal imaging (anatomical MRI, DTI, fMRI, and18FDG-PET) in a female patient with transcortical motor aphasia (TCMA) and in a male patient with conduction aphasia (CA) who had small contiguous but non-overlapping left perisylvian infarctions. Repetition in the TCMA patient was fully preserved except for a mild impairment in nonwords and digits, whereas the CA patient had impaired repetition of nonwords, digits and word triplet lists. Sentence repetition was impaired, but he repeated novel sentences significantly better than clichés. The TCMA patient had tissue damage and reduced metabolism in the left sensorimotor cortex and insula. DTI showed damage to the left temporo-frontal and parieto-frontal segments of the arcuate fasciculus (AF) and part of the left ventral stream together with well-developed right dorsal and ventral streams, as has been reported in more than one-third of females. The CA patient had tissue damage and reduced metabolic activity in the left temporoparietal cortex with additional metabolic decrements in the left frontal lobe. DTI showed damage to the left temporo-parietal and temporo-frontal segments of the AF, but the ventral stream was spared. The direct segment of the AF in the right hemisphere was also absent with only vestigial remains of the other dorsal subcomponents present, as is often found in males. fMRI during word and nonword repetition revealed bilateral perisylvian activation in the TCMA patient suggesting recruitment of spared segments of the left dorsal stream and right dorsal stream with propagation of signals to temporal lobe structures suggesting a compensatory reallocation of resources via the ventral streams. The CA patient showed a greater activation of these cortical areas than the TCMA patient, but these changes did not result in normal performance. Repetition of word triplet lists activated bilateral perisylvian cortices in both patients, but activation in the CA patient with very poor performance was restricted to small frontal and posterior temporal foci bilaterally. These findings suggest that dissociated repetition deficits in our cases are probably reliant on flexible interactions between left dorsal stream (spared segments, short tracts remains) and left ventral stream and on gender-dimorphic architecture of the right dorsal stream.

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Section: Methodsmentioning

confidence: 68%

Dissociated repetition deficits in aphasia can reflect flexible interactions between left dorsal and ventral streams and gender-dimorphic architecture of the right dorsal stream

Berthier

Dávila

Nabrozidis

et al. 2013

Front. Hum. Neurosci.

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“…For example, it was recently observed that individuals with Parkinson’s Disease with significant fatigue had reduced serotonergic function in the basal ganglia compared to patients without fatigue [48]. Tang et al [49], found that individuals with fatigue following stroke are more likely to have had infarcts in the basal ganglia, and specifically the caudate, compared to individuals without fatigue following stroke [50]. Researchers in our lab have observed cognitive fatigue to be associated with brain activity in the basal ganglia and frontal lobes using fMRI in individuals with moderate to severe TBI [11] and MS [10].…”

Section: Discussionmentioning

confidence: 99%

Examination of Cognitive Fatigue in Multiple Sclerosis using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging

et al. 2013

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The present study investigated the neural correlates of cognitive fatigue in Multiple Sclerosis (MS), looking specifically at the relationship between self-reported fatigue and objective measures of cognitive fatigue. In Experiment 1, functional magnetic resonance imaging (fMRI) was used to examine where in the brain BOLD activity covaried with “state” fatigue, assessed during performance of a task designed to induce cognitive fatigue while in the scanner. In Experiment 2, diffusion tensor imaging (DTI) was used to examine where in the brain white matter damage correlated with increased “trait” fatigue in individuals with MS, assessed by the Fatigue Severity Scale (FSS) completed outside the scanning session. During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs. DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS. Results are discussed in terms of identifying a “fatigue-network” in MS.

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“…77,86 Some studies suggest an association between PSF and subcortical infarcts 26,74,87,88 and infratentorial infarcts. 30,77 Physiologically, PSF appears be related to low excitability of corticospinal output and facilitatory synaptic inputs from cortical and subcortical sites.…”

Section: Altered Cortical Excitability and Lesion Locationmentioning

confidence: 99%

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

Hinkle¹,

Becker²,

Kim³

et al. 2017

Stroke

142

129

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At least half of all stroke survivors experience fatigue; thus, it is a common cause of concern for patients, caregivers, and clinicians after stroke. This scientific statement provides an international perspective on the emerging evidence surrounding the incidence, prevalence, quality of life, and complex pathogenesis of poststroke fatigue. Evidence for pharmacological and nonpharmacological interventions for management are reviewed, as well as the effects of poststroke fatigue on both stroke survivors and caregivers.

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Poststroke fatigue is associated with caudate infarcts

Cited by 55 publications

References 38 publications

Dissociated repetition deficits in aphasia can reflect flexible interactions between left dorsal and ventral streams and gender-dimorphic architecture of the right dorsal stream

Dissociated repetition deficits in aphasia can reflect flexible interactions between left dorsal and ventral streams and gender-dimorphic architecture of the right dorsal stream

Examination of Cognitive Fatigue in Multiple Sclerosis using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

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