Postsurgery Activation of Dormant Liver Micrometastasis: a Case Report and Review of Literature

Deylgat, Bert; Rooy, Frank Van; Vansteenkiste, Franky; Devriendt, Daniel; George, Christophe

doi:10.1007/s12029-010-9182-8

Cited by 14 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, according to the model, resection of the primary tumor in patients A and B led to a dramatic increase in the rate of growth of bone metastases. This conclusion is supported by clinical reports on sudden exacerbation of metastatic disease following surgery in patients with testicular, skin, pancreatic and lung cancers as well as osteosarcoma [9][10][11][12][13][14].…”

Section: Surgery-induced Acceleration Of Metastatic Growthmentioning

confidence: 52%

Reconstruction of the natural history of metastatic cancer and assessment of the effects of surgery: Gompertzian growth of the primary tumor

Hanin

Bunimovich‐Mendrazitsky

2014

Mathematical Biosciences

View full text Add to dashboard Cite

Section: Surgery-induced Acceleration Of Metastatic Growthmentioning

confidence: 52%

Reconstruction of the natural history of metastatic cancer and assessment of the effects of surgery: Gompertzian growth of the primary tumor

Hanin

Bunimovich‐Mendrazitsky

2014

Mathematical Biosciences

View full text Add to dashboard Cite

“…This augments an understanding of the modulation of distant tumors from the primary, a phenomena recognized more than 100 years ago and termed "concomitant immunity" (41). Third, surgical removal of the primary tumor may trigger progression of existing metastatic sites, which has been seen in the clinic (27)(28)(29)(30) as well as in animal experiments (42,43) and mathematical models (44,45). With 93% of breast cancer (early stage I and II), 98% of colon cancer (stage I, II, and III), and 71% of nonsmall cell lung cancer (early stage I and II) patients undergoing surgery as a part of their treatment (46), systemic perturbation by the presumed local treatment needs to be explored further.…”

Section: Discussionmentioning

confidence: 87%

“…We integrate an extended tumorimmune interaction model (1) into the framework to simulate growth of each metastasis. This provides nonintuitive insights into how the seeding of a new metastatic site can promote the growth of a primary tumor and offers an elegant explanation of the observation of rapid progression of metastatic disease after surgical removal of a primary tumor (27)(28)(29)(30).…”

Section: Cellsmentioning

confidence: 99%

Abscopal Benefits of Localized Radiotherapy Depend on Activated T-cell Trafficking and Distribution between Metastatic Lesions

et al. 2016

View full text Add to dashboard Cite

It remains unclear how localized radiotherapy for cancer metastases can occasionally elicit a systemic antitumor effect, known as the abscopal effect, but historically, it has been speculated to reflect the generation of a host immunotherapeutic response. The ability to purposefully and reliably induce abscopal effects in metastatic tumors could meet many unmet clinical needs. Here, we describe a mathematical model that incorporates physiologic information about T-cell trafficking to estimate the distribution of focal therapy-activated T cells between metastatic lesions. We integrated a dynamic model of tumor-immune interactions with systemic T-cell trafficking patterns to simulate the development of metastases. In virtual case studies, we found that the dissemination of activated T cells among multiple metastatic sites is complex and not intuitively predictable. Furthermore, we show that not all metastatic sites participate in systemic immune surveillance equally, and therefore the success in triggering the abscopal effect depends, at least in part, on which metastatic site is selected for localized therapy. Moreover, simulations revealed that seeding new metastatic sites may accelerate the growth of the primary tumor, because T-cell responses are partially diverted to the developing metastases, but the removal of the primary tumor can also favor the rapid growth of preexisting metastatic lesions. Collectively, our work provides the framework to prospectively identify anatomically defined focal therapy targets that are most likely to trigger an immune-mediated abscopal response and therefore may inform personalized treatment strategies in patients with metastatic disease. Cancer Res; 76(5); 1009-18. Ó2016 AACR.

show abstract

“…(b) Excision of primary melanomas precipitated metastatic spread of the disease in three skin cancer patients [ 35,36 ] . (c) In one case of pancreatic cancer, excision of the primary adenocarcinoma (via the Whipple procedure) caused surfacing of numerous previously undetectable liver metastases within 34 days of the surgery [ 37 ] .…”

Section: Treatment-related Acceleration Of Metastasismentioning

confidence: 99%

Seeing the Invisible: How Mathematical Models Uncover Tumor Dormancy, Reconstruct the Natural History of Cancer, and Assess the Effects of Treatment

Hanin

2012

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

The hypothesis of early metastasis was debated for several decades. Dormant cancer cells and surgery-induced acceleration of metastatic growth were first observed in clinical studies and animal experiments conducted more than a century ago; later, these findings were confirmed in numerous modern studies.In this primarily methodological work, we discuss critically important, yet largely unobservable, aspects of the natural history of cancer, such as (1) early metastatic dissemination; (2) dormancy of secondary tumors; (3) treatment-related interruption of metastatic dormancy, induction of angiogenesis, and acceleration of the growth of vascular metastases; and (4) the existence of cancer stem cells. The hypothesis of early metastasis was debated for several decades. Dormant cancer cells and surgery-induced acceleration of metastatic growth were first observed in clinical studies and animal experiments conducted more than a century ago; later, these findings were confirmed in numerous modern studies.We focus on the unique role played by very general mathematical models of the individual natural history of cancer that are entirely mechanistic yet, somewhat paradoxically, essentially free of assumptions about specific nature of the underlying biological processes. These models make it possible to reconstruct in considerable detail the individual natural history of cancer and retrospectively assess the effects of treatment. Thus, the models can be used as a tool for generation and validation of biomedical hypotheses related to carcinogenesis, primary tumor growth, its metastatic dissemination, growth of metastases, and the effects of various treatment modalities. We discuss in detail one such general model and review the conclusions relevant to the aforementioned aspects of cancer progression that were drawn from fitting a parametric version of the model to data on the volumes of bone metastases in one breast cancer patient and 12 prostate cancer patients.

show abstract

Postsurgery Activation of Dormant Liver Micrometastasis: a Case Report and Review of Literature

Cited by 14 publications

References 18 publications

Reconstruction of the natural history of metastatic cancer and assessment of the effects of surgery: Gompertzian growth of the primary tumor

Reconstruction of the natural history of metastatic cancer and assessment of the effects of surgery: Gompertzian growth of the primary tumor

Abscopal Benefits of Localized Radiotherapy Depend on Activated T-cell Trafficking and Distribution between Metastatic Lesions

Seeing the Invisible: How Mathematical Models Uncover Tumor Dormancy, Reconstruct the Natural History of Cancer, and Assess the Effects of Treatment

Contact Info

Product

Resources

About