Postsurgical Pathology Reporting of Thyroid Cancer in New South Wales, Australia

Kahn, Clare; Simonella, Leonardo; Sywak, Mark; Boyages, Steven; Ung, Owen; O’Connell, Dianne

doi:10.1089/thy.2011.0501

Cited by 16 publications

(11 citation statements)

References 24 publications

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“…A substantial accumulation of evidence has shown that age-adjusted incidence of thyroid cancer has increased worldwide for many decades (1)(2)(3)(4)(5)(6)(7). This trend started as early as 1940 and has steadily increased since that time (8).…”

Section: Introductionmentioning

confidence: 99%

The Clinical and Economic Burden of a Sustained Increase in Thyroid Cancer Incidence

Aschebrook‐Kilfoy

Schechter

Shih

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

201

142

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Background: Thyroid cancer incidence is increasing worldwide at an alarming rate, yet little is known of the impact this increase will have on society. We sought to determine the clinical and economic burden of a sustained increase in thyroid cancer incidence in the United States and to understand how these burdens correlate with the National Cancer Institute's (NCI) prioritization of thyroid cancer research funding.Methods: We used the NCI's SEER 13 database (1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009) and Joinpoint regression software to identify the current clinical burden of thyroid cancer and to project future incidence through 2019. We combined Medicare reimbursement rates with American Thyroid Association guidelines, and our clinical practice to create an economic model of thyroid cancer. We obtained research-funding data from the NCI's Office of Budget and Finance.Results; By 2019, papillary thyroid cancer will double in incidence and become the third most common cancer in women of all ages at a cost of $18 to $21 billion dollars in the United States. Despite these substantial clinical and economic burdens, thyroid cancer research remains significantly underfunded by comparison, and in 2009 received only $14.7 million (ranked 30th) from the NCI.Conclusion: The impact of thyroid cancer on society has been significantly underappreciated, as is evidenced by its low priority in national research funding levels.Impact: Increased awareness in the medical community and the general public of the societal burden of thyroid cancer, and substantial increases in research on thyroid cancer etiology, prevention, and treatment are needed to offset these growing concerns. Cancer Epidemiol Biomarkers Prev; 22(7); 1252-9. Ó2013 AACR.

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Section: Introductionmentioning

confidence: 99%

The Clinical and Economic Burden of a Sustained Increase in Thyroid Cancer Incidence

Aschebrook‐Kilfoy

Schechter

Shih

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

201

142

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“…In pathology literature, the definition of lymphatic invasion is not uniformly accepted and mainly focuses on lymphovascular invasion, which includes vascular invasion of follicular carcinomas 24,25. The absence of a uniformly accepted definition of lymphovascular invasion in PTC explains the wide range (5% to 81%) of lymphovascular invasion prevalence in previous studies 20,22,26,27,28,29. Because lymphatic invasions of PTC may precede lymph node metastasis and recurrence, establishment of a uniform concept of lymphatic invasion is important.…”

Section: Discussionmentioning

confidence: 99%

Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence

et al. 2014

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BackgroundIdentification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, 'tumor sprouting,' and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence.MethodsWe analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics.ResultsTumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence-free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence.ConclusionsIn conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.

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“…Levels I and II evidence demonstrated significant improvement of the completeness of reporting of required data elements for prostate cancer, 17 colorectal cancer, [2][3][4][5][6] pancreatic cancer, 18 breast cancer, 3,7,8 and melanoma. 20 In these studies, the required data fields were based on widely accepted clinical staging systems, including TNM staging, 6,17,18 nationally adopted guidelines based on specialty society clinical requirements, 2,3,5,7,8,20,21 and CAP Cancer Protocols. 4,6,18,19 In all reports that included a statistical analysis, the difference in completeness of required data elements was highly significant with P-values ranging from P , .05 to , .001.…”

Section: Guideline Statementsmentioning

confidence: 99%

Bone Marrow Synoptic Reporting for Hematologic Neoplasms: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center

Sever

Abbott

Baca³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

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Postsurgical Pathology Reporting of Thyroid Cancer in New South Wales, Australia

Cited by 16 publications

References 24 publications

The Clinical and Economic Burden of a Sustained Increase in Thyroid Cancer Incidence

The Clinical and Economic Burden of a Sustained Increase in Thyroid Cancer Incidence

Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence

Bone Marrow Synoptic Reporting for Hematologic Neoplasms: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center

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