Posttransplant eosinophilic gastroenteritis in children

Dhawan, Anil; Seemayer, Thomas A.; Pinsinski, Christina; Gross, Thomas G.; Shaw, Byers W.; Mack, David R.

doi:10.1002/lt.500030606

Cited by 35 publications

(25 citation statements)

References 13 publications

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“…Drug or toxin exposure is the cause of a few cases of eosinophilic gastroenteritis [53][54][55][56][57][58][59]. Recently, a case of enalapril-induced eosinophilic gastroenteritis was reported in a 63-year-old woman from Chicago [57]; in another case, gemfibrozil was associated [58].…”

Section: Drugsmentioning

confidence: 98%

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Eosinophilic gastroenteritis

Daneshjoo

Talley

2002

Curr Gastroenterol Rep

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Eosinophilic gastroenteritis is a rare gastrointestinal (GI) disorder of undetermined cause characterized by infiltration of eosinophils in the GI tract. Eosinophils accumulate in tissues and may release highly cytotoxic granular proteins, which cause severe tissue damage characteristic of eosinophilic gastroenteritis. Eotaxin may play a role in the recruitment of eosinophils into tissue in combination with chemoattractants and cytokines, including interleukin 3 and 5 and granulocyte-macrophage colony-stimulating factor. Food allergy, especially in children, can be a triggering factor, and an amino acid-based diet may be helpful. Accumulation of eosinophils in the gut is a common feature in food-induced GI disorders that can be regulated through a complex molecular network involving Th2 cells, various cytokines, and chemokines. Eosinophilic gastroenteritis has a wide spectrum of clinical presentation depending on the site of involvement. It may be confused with irritable bowel syndrome or dyspepsia and, rarely, mimics pancreatitis or appendicitis. Diagnosis is important and is usually made by a pathologist. Eosinophilic gastroenteritis is a treatable disease; patients generally respond to steroid therapy, although relapse is common. Non-enteric-coated budesonide, a locally acting corticosteroid with little risk of adrenal suppression, may be substituted, although more experience is needed. Promising new drugs for eosinophilic gastroenteritis include montelukast, a selective leukotriene receptor antagonist, and suplaplast tosilate, a selective Th2 cytokine inhibitor with inhibitory effects on allergy-induced eosinophilic infiltration and IgE production. Although it is likely a separate disease, more experience has accumulated, and an elimination or specific amino acid-based diet appears to be helpful in treatment.

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Section: Drugsmentioning

confidence: 98%

“…Recently, a case of enalapril-induced eosinophilic gastroenteritis was reported in a 63-year-old woman from Chicago [57]; in another case, gemfibrozil was associated [58]. Cyclosporine has also been implicated as a cause of eosinophilic gastroenteritis [59].…”

Section: Drugsmentioning

confidence: 98%

Eosinophilic gastroenteritis

Daneshjoo

Talley

2002

Curr Gastroenterol Rep

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“…This diversity in presentation depends mainly on whether the disease is primary or secondary. Various secondary causes of EG have been described such as inflammatory bowel disease, autoimmune diseases, reactions to medications,1 infections, hypereosinophilic syndrome, and following solid organ transplantation 2 , 3…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic gastroenteritis causing stenosis of bulbo-duodenal junction: medical and endoscopic management

Ashraf

Ashraf²,

Al-Karawi³

et al. 2009

Case Reports

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Eosinophilic gastroenteritis is a rare disease characterised by tissue eosinophilia that can involve any layer or part of the gut from the oesophagus to the rectum. In Saudi Arabia, the disease has not been reported in the literature before. We report the disease entity as an unusual cause of gastric outlet obstruction. A 50-year-old man was admitted through the gastrointestinal clinic with complaints of epigastric pain associated with dyspepsia for 1 month, and weight loss of 4 kg in 2 months. Examination revealed only the epigastric tenderness on deep palpation. Laboratory investigations including full blood count, liver function tests and renal function tests were normal. Gastroscopy disclosed stenosis of the second and third part of the duodenum. Biopsies were taken and the patient underwent endoscopic dilatation of the pylorus and duodenal bulb. Histopathology showed chronic active eosinophilic inflammation. The patient was successfully treated with a tapering course of steroids and had a complete recovery post-endoscopic dilatation.

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“…Repeated publications have reported on the occurrence of gastrointestinal eosinophilic inflammation and peripheral eosinophilia after organ transplantation [120][121][122][123], a problem that affects all the digestive tract segments and which also involves the oesophageal mucosa. Moreover, a higher rate of graft loss in these patients has been observed; therefore, this manifestation has been explained as a local graft-versus-host disease [124].…”

Section: Gastrointestinal Eosinophilia and Graft-versus-host Diseasementioning

confidence: 98%

Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia

Lucendo

2015

Best Practice & Research Clinical Gastroenterology

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Posttransplant eosinophilic gastroenteritis in children

Cited by 35 publications

References 13 publications

Eosinophilic gastroenteritis

Eosinophilic gastroenteritis

Eosinophilic gastroenteritis causing stenosis of bulbo-duodenal junction: medical and endoscopic management

Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia

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