Posttransplant Epstein-Barr Virus Infection Is Associated With Elevated Levels of Cd19+ B Lymphocytes1

Morrissey, Paul; Lorber, Kathleen M.; Marcarelli, Margaret; Bia, Margaret J.; Kliger, Alan S.; Lorber, Marc I.

doi:10.1097/00007890-199559040-00035

Cited by 1 publication

(1 citation statement)

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“…CTL are of outstanding importance for maintaining the virushost balance in immunocompetent individuals [4][5][6]. The importance of this virus-specific defence mechanism is also inferred from data showing a high frequency of EBV-induced lymphoproliferative disorders in patients affected by inherited immunodeficiencies [5,25,26] or in individuals who experience acquired immunosuppression [6,[27][28][29]. In particular, it is noteworthy that a regression of EBV-induced lymphoproliferative disorders was described in transplant patients following reduction or discontinuation of immunosuppressive therapy [30] or adoptive transfer of either donor leucocytes [31] or virus-specific donor T cell lines [32].…”

Section: Discussionmentioning

confidence: 99%

High frequency of Epstein–Barr virus (EBV) lymphoblastoid cell line-reactive lymphocytes in cord blood: evaluation of cytolytic activity and IL-2 production

Moretta¹,

Comoli²,

Montagna³

et al. 1997

Clinical and Experimental Immunology

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SUMMARYWe investigated natural immunity towards autologous EBV lymphoblastoid cell lines (EBV-LCL) in the cord blood. Cord blood lymphocytes (CBL) from 20 healthy neonates were examined together with three EBV and one EBV ÿ adult donors. We found that high frequencies of EBV-LCL-reactive cytotoxic lymphocytes, ranging from 1/190 to 1/12 205 were detectable in EBV donor. These data demonstrate that CBL are able to develop a strong innate immunity, directed against autologous EBV-infected cells, mediated by both NK cells and CD4T lymphocytes. This characteristic may be relevant for protection against viral infections in both neonates and patients given cord blood transplantation (CBT).

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