Posttransplant Lymphoproliferative Disorders of the Central Nervous System After Kidney Transplantation: Single Center Experience Over 40 Years -Two Case Reports-

Abstract

Further reduction of mycophenolate mofetil and increase of steroid led to second remission. The disease remained in complete remission at 60 months after first onset. A 61-year-old woman suffered onset of CNS PTLD 19 years after renal transplantation. After tumor removal, whole brain irradiation was performed. The disease remained in remission at 54 months after onset. Histological examination showed polymorphic-type PTLD in both cases. The first case of polymorphic CNS PTLD was successfully treated by modulation of immunosuppressants without radiation therapy even at recurrence. PTLD should be included in the differential diagnosis of brain tumors in recipients of solid organ transplantation, and histological subtype should be carefully identified to establish the correct treatment strategy.

Spontaneous regression of central nervous system posttransplant lymphoproliferative disease

“…[ 8 ] Arita H, et al presented two cases of P-PTLD treated with RI plus steroids and surgery plus irradiation separately. [ 9 ] Velvet AJJ, et al reported a case treated with RI, craniotomy, radiotherapy and rituximab. [ 10 ] The outcomes of these cases are optimistic, but due to the rarity, there is no consensus of optimal treatment.…”