Objective: This study aims to explore and analyze the associations among posttraumatic symptoms, meaning in life dimensions, and perceived family functioning in trauma-exposed university students. Method: Participants (N = 158) answered a sociodemographic questionnaire, the Posttraumatic Stress Global Assessment (Crespo et al., 2017), the Purpose in Life Test (Crumbaugh & Maholick, 1969), and the Family APGAR (Smilkstein, 1978). Results: Outcomes indicated several negative associations between posttraumatic symptoms and both meaning in life and family functioning areas. Conclusions: These findings suggest family functioning and meaning-in-life clinical practical relevance concerning the assessment, prevention, and intervention in persons affected by trauma.