IntroductionNurses, assuming a wide range of clinical and patient care responsibilities in a healthcare team, are highly susceptible to direct and indirect exposure to traumatic experiences. However, literature has shown that nurses with certain traits developed a new sense of personal strength in the face of adversity, known as post‐traumatic growth (PTG). This review aimed to synthesize the best available evidence to evaluate personal and work‐related factors associated with PTG among nurses.DesignMixed studies systematic review.MethodsStudies examining factors influencing PTG on certified nurses from all healthcare facilities were included. Published and unpublished studies were identified by searching 12 databases from their inception until 4th February 2023. Two reviewers independently screened, appraised, piloted a data collection form, and extracted relevant data. Meta‐summary, meta‐synthesis, meta‐analysis, as well as subgroup and sensitivity analyses were performed. Integration of results followed result‐based convergent design.ResultsA total of 98 studies with 29,706 nurses from 18 countries were included. These included 49 quantitative, 42 qualitative, and seven mixed‐methods studies. Forty‐six influencing factors were meta‐analyzed, whereas nine facilitating factors were meta‐summarized. A PTG conceptual map was created. Four constructs emerged from the integration synthesis: (a) personal system, (b) work‐related system, (c) event‐related factors, and (d) cognitive transformation.ConclusionThe review findings highlighted areas healthcare organizations could do to facilitate PTG in nurses. Practical implications include developing intervention programs based on PTG facilitators. Further research should examine the trend of PTG and its dynamic response to different nursing factors.Clinical RelevanceResearch on trauma‐focused therapies targeting nurses' mental health is lacking. Therefore, findings from this review could inform healthcare organizations on the PTG phenomenon and developing support measures for nurses through healthcare policies and clinical practice.