Posttraumatic Headache

Dwyer, Brigid

doi:10.1055/s-0038-1673692

Cited by 28 publications

(18 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mast cell activation-mediated histamine and other mediators contribute to the common posttraumatic headache in TBI patients [49]. About 18-58% of TBI patients show posttraumatic headache (PTH) for one year after trauma, and PTH is a significant severity predictor after concussion [50][51][52]. Acute activation of meningeal mast cells contributes to chronic pain and targeting mast cells for early prophylactic treatment after mild closed-head injury [53].…”

Section: Discussionmentioning

confidence: 99%

Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury

Kempuraj

Ahmed

Selvakumar

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is one of the major health problems worldwide that causes death or permanent disability through primary and secondary damages in the brain. TBI causes primary brain damage and activates glial cells and immune and inflammatory cells, including mast cells in the brain associated with neuroinflammatory responses that cause secondary brain damage. Though the survival rate and the neurological deficiencies have shown significant improvement in many TBI patients with newer therapeutic options, the underlying pathophysiology of TBI-mediated neuroinflammation, neurodegeneration, and cognitive dysfunctions is understudied. In this study, we analyzed mast cells and neuroinflammation in weight drop-induced TBI. We analyzed mast cell activation by toluidine blue staining, serum chemokine C-C motif ligand 2 (CCL2) level by enzyme-linked immunosorbent assay (ELISA), and proteinase-activated receptor-2 (PAR-2), a mast cell and inflammation-associated protein, vascular endothelial growth factor receptor 2 (VEGFR2), and blood-brain barrier tight junction-associated claudin 5 and Zonula occludens-1 (ZO-1) protein expression in the brains of TBI mice. Mast cell activation and its numbers increased in the brains of 24 h and 72 h TBI when compared with sham control brains without TBI. Mouse brains after TBI show increased CCL2, PAR-2, and VEGFR2 expression and derangement of claudin 5 and ZO-1 expression as compared with sham control brains. TBI can cause mast cell activation, neuroinflammation, and derangement of tight junction proteins associated with increased BBB permeability. We suggest that inhibition of mast cell activation can suppress neuroimmune responses and glial cell activation-associated neuroinflammation and neurodegeneration in TBI.

show abstract

Section: Discussionmentioning

confidence: 99%

Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury

Kempuraj

Ahmed

Selvakumar

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…Migraine can also occur or become appreciably worse after trauma (termed post-traumatic headache), particularly after a mild traumatic brain injury or concussion (Dwyer, 2018).…”

Section: Discussionmentioning

confidence: 99%

Abnormalities in cortical pattern of coherence in interictal migraine detected using ultra high-density EEG

Chamanzar¹,

Haigh

Grover³

et al. 2020

Preprint

View full text Add to dashboard Cite

Individuals with migraine generally experience photophobia and/or phonophobia during and between migraine attacks. Many different mechanisms have been postulated to explain these migraine phenomena including abnormal patterns of connectivity across the cortex. The results, however, remain contradictory and there is no clear consensus on the nature of the cortical abnormalities in migraine. Here, we uncover alterations in cortical patterns of coherence (connectivity) in interictal migraineurs during the presentation of visual and auditory stimuli, as well as at rest, to capitalize on the sensory sensitivities that are characteristic of migraine, and to reconcile the conflicting literature on migraine cortical connectivity. We used a high-density electroencephalography (HD-EEG) system, with 128 customized electrode locations, to measure inter- and intra-hemispheric coherence from 17 individuals with migraine (12 female) in the interictal period, and 18 age- and gender-matched healthy control subjects, during visual (vertical grating pattern) and auditory (modulated tone) stimulation which varied in temporal frequency (4 and 6Hz), and during rest. To ensure that participants were attending, participants performed a color detection task at fixation. Analyses of the EEG signal included characterizing the inter- and intra-hemisphere coherence between the scalp EEG channels over 2-second time intervals and over different frequency bands at different spatial distances and spatial clusters, and Pearson's correlation coefficients (PCCs) were estimated at zero-lag. Repeated measures (between-group) analyses-of-variance with post hoc multiple comparison correction were conducted. Relative to controls, migraineurs exhibited significantly (i) faster color detection performance; (ii) lower long-distance spatial coherence of alpha-band activity during both evoked conditions, regardless of the stimulation frequency; (iii) lower coherence between the right frontal cluster and all clusters in the left hemisphere (inter-hemisphere coherence) during 4Hz auditory and visual stimulation; and (iv) lower long-distance coherence (in all frequency bands) between the right occipito-parietal cluster and all other clusters during the (4Hz and 6Hz) visual stimuli. No significant group differences were observed in the resting state data. The abnormal patterns of EEG coherence in interictal migraineurs during visual and auditory stimuli may be associated with cortical hyper-excitability in migraineurs.

show abstract

“…The diagnostic criteria of mTBI with posttraumatic headache was chosen because it is a more common clinical presentation and a more debilitating form of chronic mTBI compared with that without headaches. 11 Based on the current literature, the pRNFL and mGCL measurements in migraine patients have been very inconsistent. Some studies have found statistically significant diffuse thinning in the mGCL and/or pRNFL in the eyes of migraine patients compared with that of controls, whereas others have found thinning in only certain mGCL and/or pRNFL quadrants.…”

Section: Discussionmentioning

confidence: 99%

“…We considered the currently available TBI screening questionnaires as insensitive and unreliable for the purposes of our study; rather, we used Department of Defense criteria for the diagnosis of mTBI in conjunction with the associated symptoms of posttraumatic headache, present in up to 90% of mTBI patients. 11 We excluded subjects with any systemic diseases, other neurological disorders, and ophthalmological disorders that would affect the OCT measurements.…”

Section: Subject Selectionmentioning

confidence: 99%

Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury

Chan

Hills

Bakall

et al. 2019

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. To analyze the clinical presentation and optical coherence tomography (OCT) findings in indirect traumatic optic neuropathy (ITON) in veterans with chronic mild traumatic brain injury (mTBI). METHODS. This retrospective study is the first to describe the OCT pattern of subclinical to mild ITON in veterans with chronic mTBI. The thicknesses of the macular ganglion cell layer (mGCL), peripapillary retinal nerve fiber layer (pRNFL), and subfoveal choroidal layer were analyzed in young veterans who had mTBI of >6 months' duration and either blunt head injury or improvised explosive device (IED) concussions. RESULTS. Three major OCT findings were demonstrated: (1) temporal pRNFL thinning was associated with subclinical TON in the eyes of chronic mTBI patients compared with controls; within mTBI subjects, nasal mGCL thinning at the 3-mm modified Early Treatment Diabetic Retinopathy Study circle diameter distance from the fovea correlated with the corresponding temporal retinal nerve fiber layer thinning; (2) inner (1 mm) superior thinning was greater than that of the temporal mGCL in blunt head injury and could potentially distinguish it from IED concussive head trauma; and (3) subfoveal choroidal thinning was significantly worse in eyes of mTBI patients compared with those of controls. CONCLUSIONS. These OCT findings may contribute to the understanding of the spectrum of visual injuries resulting from head trauma.

show abstract

Posttraumatic Headache

Cited by 28 publications

References 56 publications

Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury

Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury

Abnormalities in cortical pattern of coherence in interictal migraine detected using ultra high-density EEG

Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury

Contact Info

Product

Resources

About