Posttraumatic smell loss: Relationship of psychophysica tests and volumes of the olfactory bulbs and tracts and the temporal lobes

Yousem, David M.; Geckle, Rena J.; Bilker, Warren B.; Kröger, Hans; Doty, Richard L.

doi:10.1016/s1076-6332(99)80449-8

Cited by 112 publications

(93 citation statements)

References 14 publications

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“…Bruising of the antero-medial aspect of the frontal lobes, the center for olfaction, can also compromise olfaction [76]. MRI studies of civilians with posttraumatic anosmia demonstrated damage to the olfactory bulbs and tracts, subfrontal cortex, and temporal lobes [77][78]. Importantly, individuals often do not recognize that they have impaired olfaction following TBI [75].…”

Section: Discussionmentioning

confidence: 99%

Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions

Ruff

Ruff²,

Wang³

2008

JRRD

110

146

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Abstract-Traumatic brain injury (TBI) is a common injury type among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) veterans, and headaches are a frequent consequence of TBI. We examined the hypothesis that among veterans who reported mild TBI caused by exposure to an explosion during deployment in OIF/OEF, those with residual neurocognitive deficits would have a higher frequency of headaches and more severe headaches. We evaluated 155 consecutive veterans with neurological examination and neuropsychological testing. We excluded 29 veterans because they did not have mild TBI or they did not complete the evaluation. We analyzed headache pattern, intensity, and frequency. Among the 126 veterans studied, 80 had impairments on neurological examination or neuropsychological testing that were best attributed to TBI. Veterans with impairments had been exposed to more explosions and were more likely to have headache, features of migraine, more severe pain, more frequent headaches, posttraumatic stress disorder, and impaired sleep with nightmares.

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Section: Discussionmentioning

confidence: 99%

Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions

Ruff

Ruff²,

Wang³

2008

JRRD

110

146

View full text Add to dashboard Cite

show abstract

“…Injury to the olfactory parenchyma, specifically the anterior frontal and temporal regions may result in smell loss. In a magnetic resonance imaging study of 24 patients with post-traumatic anosmia, Yousem et al [31,32] found the most common parenchymal lesions were in the olfactory bulb and frontal lobe. Interestingly, most patients in the study with frontal or olfactory bulb injury had bilateral lesions and documented olfactory bulb volume loss.…”

Section: Discussionmentioning

confidence: 99%

Olfactory dysfunction: A sequela of pediatric blunt head trauma

Sandford

Davidson

Herrera

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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“…Axotomy or ZnSO 4 irrigation of the olfactory neuroepithelium does lead to a 33 to 75% decrease of bulb weight in rats after a month, [73][74][75] largely reflecting degenerative changes within the glomerular and external plexiform layers of the bulb. In humans, decreased olfactory bulb volumes determined using magnetic resonance imaging have been reported secondary to age, 76 head trauma, 77 upper respiratory infections that induce epithelial damage, 78 and schizophrenia. 79 Volume decrements of approximately 23% were reported for both older persons and those with schizophrenia.…”

Section: Centrifugal Afferent Innervation Comes From the Horizontal Lmentioning

confidence: 99%

The olfactory vector hypothesis of neurodegenerative disease: Is it viable?

Doty

2008

Annals of Neurology

Self Cite

355

279

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Environmental agents, including viruses, prions, and toxins, have been implicated in the cause of a number of neurodegenerative diseases, most notably Alzheimer's and Parkinson's diseases. The presence of smell loss and the pathological involvement of the olfactory pathways in the formative stages of Alzheimer's and Parkinson's diseases, together with evidence that xenobiotics, some epidemiologically linked to these diseases, can readily enter the brain via the olfactory mucosa, have led to the hypothesis that Alzheimer's and Parkinson's diseases may be caused or catalyzed by agents that enter the brain via this route. Evidence for and against this concept, the “olfactory vector hypothesis,” is addressed in this review. Ann Neurol 2008;63:7–15

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Posttraumatic smell loss: Relationship of psychophysica tests and volumes of the olfactory bulbs and tracts and the temporal lobes

Cited by 112 publications

References 14 publications

Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions

Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions

Olfactory dysfunction: A sequela of pediatric blunt head trauma

The olfactory vector hypothesis of neurodegenerative disease: Is it viable?

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