Posttraumatic Stress Disorder Complicated by Traumatic Brain Injury: A Narrative Review

Aita, Stephen L.; Schuler, Kaitlyn R.; Isaak, Steven L.; Borgogna, Nicholas C.; Moncrief, Grant G.; Hollis, Sean; Hill, Benjamin D.

doi:10.1007/s42399-023-01431-1

Cited by 5 publications

(2 citation statements)

References 116 publications

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“…Posttraumatic headache (PTH) is a secondary headache disorder defined by the third version of the International Classification of Headache Disorders (ICHD-3) as a headache caused by underlying head and/or neck trauma or injury [ 1 , 2 ]. This condition, which can cause severe pain and disability, is one of the most common symptoms after mild traumatic brain injury (mTBI) and one of the most likely symptoms to persist after mTBI [ 3 , 4 ]. Previous studies have reported that the cumulative incidence of PTH within 1 year after mTBI is as high as 91% [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Li,

Zhang,

Ren

et al. 2024

J Headache Pain

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Objective The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuropathological activity pattern. It is composed of functionally different subdivisions and each of which plays different role in PTH neuropathology. Methods Ninety-four mTBI patients were included in this study. Based on perfusion imaging data obtained from arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI), this study evaluated the insular subregion perfusion-based functional connectivity (FC) and its correlation with clinical characteristic parameters in patients with PTH after mTBI and non-headache mTBI patients. Results The insular subregions of mTBI + PTH (mTBI patients with PTH) and mTBI-PTH (mTBI patients without PTH) group had positive perfusion-based functional connections with other insular nuclei and adjacent discrete cortical regions. Compared with mTBI-PTH group, significantly increased resting-state perfusion-based FC between the anterior insula (AI) and middle cingulate cortex (MCC)/Rolandic operculum (ROL), between posterior insula (PI) and supplementary motor area (SMA), and decreased perfusion-based FC between PI and thalamus were found in mTBI + PTH group. Changes in the perfusion-based FC of the left posterior insula/dorsal anterior insula with the thalamus/MCC were significant correlated with headache characteristics. Conclusions Our findings provide new ASL-based evidence for changes in the perfusion-based FC of the insular subregion in PTH patients attributed to mTBI and the association with headache features, revealing the possibility of potential neuroplasticity after PTH. These findings may contribute to early diagnosis of the disease and follow-up of disease progression.

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Section: Introductionmentioning

confidence: 99%

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Li,

Zhang,

Ren

et al. 2024

J Headache Pain

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“…However, these symptoms were more strongly associated with PTSD and depression than with the history of mTBI. PTSD is also a major risk factor of PTH development following a mTBI and could lead to severe headaches due to the psychological burden of the experienced physical trauma underlying the mTBI [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Post-Traumatic Headache: A Review of Prevalence, Clinical Features, Risk Factors, and Treatment Strategies

Mavroudis

Ciobîcă

Luca

et al. 2023

JCM

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Post-traumatic headache (PTH) is a common and debilitating consequence of mild traumatic brain injury (mTBI) that can occur over one year after the head impact event. Thus, better understanding of the underlying pathophysiology and risk factors could facilitate early identification and management of PTH. There are several factors that could influence the reporting of PTH prevalence, including the definition of concussion and PTH. The main risk factors for PTHs include a history of migraines or headaches, female gender, younger age, greater severity of the head injury, and co-occurring psychological symptoms, such as anxiety and depression. PTH clinical profiles vary based on onset, duration, and severity: tension-type headache, migraine headaches, cervicogenic headache, occipital neuralgia, and new daily persistent headache. Pharmacological treatments often consist of analgesics and non-steroidal anti-inflammatory drugs, tricyclic antidepressants, or antiepileptic medication. Cognitive behavioral therapy, relaxation techniques, biofeedback, and physical therapy could also be used for PTH treatment. Our work highlighted the need for more rigorous studies to better describe the importance of identifying risk factors and patient-centered treatments and to evaluate the effectiveness of the existing treatment options. Clinicians should consider a multidisciplinary approach to managing PTH, including pharmacotherapy, cognitive behavioral therapy, and lifestyle changes.

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PEG hydrogel containing dexamethasone-conjugated hyaluronic acid reduces secondary injury and improves motor function in a rat moderate TBI model

Jones,

Elliott,

Liao

et al. 2023

Experimental Neurology

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Posttraumatic Stress Disorder Complicated by Traumatic Brain Injury: A Narrative Review

Cited by 5 publications

References 116 publications

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Post-Traumatic Headache: A Review of Prevalence, Clinical Features, Risk Factors, and Treatment Strategies

PEG hydrogel containing dexamethasone-conjugated hyaluronic acid reduces secondary injury and improves motor function in a rat moderate TBI model

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