Posttraumatic stress disorder is associated with enhanced interleukin-6 response to mental stress in subjects with a recent myocardial infarction

Lima, Bruno B; Hammadah, Muhammad; Wilmot, Kobina; Pearce, Brad D.; Shah, Amit; Levantsevych, Oleksiy; Kaseer, Belal; Obideen, Malik; Gafeer, Mohamad Mazen; Kim, Jeong Hwan; Sullivan, Samaah; Lewis, Tené T.; Weng, Lei; Elon, Lisa; Li, Lian; Bremner, J. Douglas; Raggi, Paolo; Quyyumi, Arshed A.; Vaccarino, Viola

doi:10.1016/j.bbi.2018.08.015

Cited by 55 publications

(43 citation statements)

References 64 publications

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“…The symptom cluster most strongly associated with MSIMI was reexperiencing trauma, followed by avoidance and numbing, while hyperarousal was not significantly associated with MSIMI. This is consistent with our prior results, 10 which associated symptoms of reexperiencing trauma with higher interleukin-6 response to mental stress in the same patient population. However, whether inflammation is directly associated with MSIMI is still unclear, given that previous literature has yielded mixed results.…”

Section: Discussionsupporting

confidence: 93%

“…[4][5][6][7] The precise mechanisms through which PTSD may increase the risk of adverse cardiovascular outcomes are not fully understood. Poor health behaviors, 8 inflammation, 9,10 and abnormal autonomic function 11,12 have been linked to both PTSD and coronary heart disease (CHD) but whether these factors fully explain the increased risk associated with PTSD is debatable. 3 Another possible mechanism mediating the association between PTSD and adverse outcomes after MI is that patients with MI and comorbid PTSD might be susceptible to developing myocardial ischemia during psychologic stress.…”

Section: Introductionmentioning

confidence: 99%

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Association of Posttraumatic Stress Disorder With Mental Stress–Induced Myocardial Ischemia in Adults After Myocardial Infarction

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IMPORTANCE Posttraumatic stress disorder (PTSD) is prevalent among patients who survived an acute coronary syndrome and is associated with adverse outcomes, but the mechanisms underlying these associations are unclear. OBJECTIVE To evaluate the association of PTSD with mental stress-induced myocardial ischemia among individuals who survived a myocardial infarction (MI). DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study included 303 patients aged 18 to 60 years enrolled from a university-affiliated network. Participants had a verified history of MI within 8 months. Data were collected from June 2011 to March 2016, and data analysis was conducted from March to June 2019. EXPOSURES A clinical diagnosis of PTSD (lifetime and current) was obtained using the Structured Clinical Interview from the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition), and PTSD symptom subscales were assessed with the civilian version of the PTSD Symptom Checklist. MAIN OUTCOMES AND MEASURES Patients received technetium 99m-labeled sestamibi myocardial perfusion imaging at rest, with mental stress (ie, a speech task) and conventional stress (ie, exercise or pharmacologic). A summed difference score (ie, the difference between stress and rest scores) was used to assess ischemia under both stress conditions. RESULTS Among 303 participants (148 [48.8%] women; 198 [65.3%] African American; mean [SD] age, 51 [7] years), the prevalence of PTSD was 14.5% (44 patients). Patients with PTSD had a higher rate of ischemia with mental stress than those without PTSD (12 of 44 [27.3%] vs 38 of 259 [14.7%];

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Association of Posttraumatic Stress Disorder With Mental Stress–Induced Myocardial Ischemia in Adults After Myocardial Infarction

et al. 2020

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“…As depression and stress are associated with an increase of pro-inflammatory cytokines including Interleukin-1 beta (IL-1β) (Lu et al, 2017), Interleukin-6 (IL-6) (Liu et al, 2012), Tumor Necrosis Factor-α (TNF-α) (Osimo et al, 2020) and C-reactive protein (CRP) (Ng et al, 2018), future immunopsychiatry service and research should monitor the relationship between levels of pro-inflammatory cytokines and depression in psychiatric patients during the pandemic. Similarly, PTSD is associated with enhanced interleukin-6 response to mental stress (Lima et al, 2019). If pro-inflammatory cytokines were found to be increased in psychiatric patients during lockdown, further research is required to evaluate pharmacological intervention (Lee et al, 2018a,b) and non-pharmacological intervention (e.g.…”

Section: Discussionmentioning

confidence: 99%

Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry

Hao

Tan

Jiang

et al. 2020

Brain, Behavior, and Immunity

897

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…Families of PRRs that are components of the inflammasome complex include nucleotide-binding domain, leucine-rich repeat containing proteins (NLRs, or NOD-like receptors). These induce caspase-1 and the inflammatory response and play a role in diseases involving inflammation [ 96 ], including PTSD and depression [ 92 , 97 ]. Specialized proresolving mediators (SPMs), including resolvins, lipoxins, maresins, and protectins, act as brakes on the inflammatory response and are released at the time of the initial inflammatory response [ 98 , 99 , 100 ].…”

Section: Methodsmentioning

confidence: 99%

Diet, Stress and Mental Health

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Introduction: There has long been an interest in the effects of diet on mental health, and the interaction of the two with stress; however, the nature of these relationships is not well understood. Although associations between diet, obesity and the related metabolic syndrome (MetS), stress, and mental disorders exist, causal pathways have not been established. Methods: We reviewed the literature on the relationship between diet, stress, obesity and psychiatric disorders related to stress. Results: Diet and obesity can affect mood through direct effects, or stress-related mental disorders could lead to changes in diet habits that affect weight. Alternatively, common factors such as stress or predisposition could lead to both obesity and stress-related mental disorders, such as depression and posttraumatic stress disorder (PTSD). Specific aspects of diet can lead to acute changes in mood as well as stimulate inflammation, which has led to efforts to assess polyunsaturated fats (PUFA) as a treatment for depression. Bidirectional relationships between these different factors are also likely. Finally, there has been increased attention recently on the relationship between the gut and the brain, with the realization that the gut microbiome has an influence on brain function and probably also mood and behavior, introducing another way diet can influence mental health and disorders. Brain areas and neurotransmitters and neuropeptides that are involved in both mood and appetite likely play a role in mediating this relationship. Conclusions: Understanding the relationship between diet, stress and mood and behavior could have important implications for the treatment of both stress-related mental disorders and obesity.

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Posttraumatic stress disorder is associated with enhanced interleukin-6 response to mental stress in subjects with a recent myocardial infarction

Abstract: MI patients with current PTSD exhibit enhanced IL-6 response to psychosocial stress, suggesting a mechanistic link between PTSD and adverse cardiovascular outcomes as well as other diseases associated with inflammation.

Cited by 55 publications

References 64 publications

Association of Posttraumatic Stress Disorder With Mental Stress–Induced Myocardial Ischemia in Adults After Myocardial Infarction

Association of Posttraumatic Stress Disorder With Mental Stress–Induced Myocardial Ischemia in Adults After Myocardial Infarction

Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry

Diet, Stress and Mental Health

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