Posttraumatic stress disorder prevalence in medical populations: A systematic review and meta-analysis

Cyr, Samuel; Guo, De Xuan; Marcil, Marie-Joëlle; Dupont, Patrice; Jobidon, Laurence; Benrimoh, David; Guertin, Marie-Claude; Brouillette, Judith

doi:10.1016/j.genhosppsych.2021.01.010

Cited by 16 publications

(5 citation statements)

References 333 publications

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“…Since propofol has no analgesic or neuromuscular effects, intraoperative awareness and unanticipated movement are more likely in TIVA management. Intraoperative awareness causes posttraumatic stress disorder, and body movement may cause unexpected brain injury or cervical spinal cord injury because the patient’s head is fixed by pinning [ 8 , 19 ]. Therefore, intraoperative awareness and unanticipated body movement should be avoided, especially in neurosurgery.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Low Concentration of Sevoflurane Combined With Propofol on Transcranial Electrical Stimulation Motor Evoked Potential: A Case Series

Yamada¹,

Chaki²,

Kimura³

et al. 2023

Cureus

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Transcranial electrical motor evoked potential (TCeMEP) is used to monitor the integrity of intraoperative motor function. Total intravenous anesthesia (TIVA) is the preferred method because its effect on MEP is relatively smaller than volatile anesthetics. However, maintaining the balanced anesthesia in long-time surgery using TIVA is challenging and may sometime cause problems including body movement during microsurgery. Such problems can be avoided by intraoperative anesthesia management using a mixture of propofol and a low concentration of sevoflurane. We recorded TCeMEP under a mixture of propofol and low concentration of sevoflurane anesthesia in three cases of neurosurgery. Anesthesia was induced with a 5.0 µg/mL target-controlled infusion of propofol and 0.6 mg/kg rocuronium. General anesthesia was maintained by propofol and 0.1-0.25 µg/kg/min remifentanil infusion. After the recording of control TCeMEP, sequential inhalation of 0.2 minimum alveolar concentration (MAC) and 0.5 MAC of sevoflurane was performed. The duration of each sevoflurane inhalation was 10 minutes, and the MACs were adjusted by the patient's age. In our cases, the combination of propofol and 0.2 MAC sevoflurane suppressed the amplitude of TCeMEP to 38.0±21.7% (379.8±212.0 µV), but the amplitude was high enough for evaluation of motor function monitoring. On the other hand, the combination of 0.5 MAC sevoflurane greatly decreased the amplitude of TCeMEP to 6.3±6.0% (71.9±66.9 µV) resulting in less than 150 µV, and it was difficult to record the change in TCeMEP amplitude over time. The combination of 0.2 MAC sevoflurane with TIVA might enable TCeMEP monitoring with TIVA.

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Section: Discussionmentioning

confidence: 99%

Effect of a Low Concentration of Sevoflurane Combined With Propofol on Transcranial Electrical Stimulation Motor Evoked Potential: A Case Series

Yamada¹,

Chaki²,

Kimura³

et al. 2023

Cureus

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“…The suitability of assessing PTSD after medical trauma or significant medical conditions has received more attention in the medical literature. 19…”

Section: Discussionmentioning

confidence: 99%

“…The suitability of assessing PTSD after medical trauma or significant medical conditions has received more attention in the medical literature. 19 PTSD is a common mental health disorder in military Veterans with an overall prevalence between 11% and 20% and higher rates for those deployed to combat theaters. Up to 59% of Veterans diagnosed with PTSD also meet criteria for an anxiety disorder.…”

Section: Discussionmentioning

confidence: 99%

Impact of comorbid post traumatic stress disorder on multiple sclerosis in military veterans: A population-based cohort study

et al. 2021

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Background: Very little is known regarding the impact of post traumatic stress disorder (PTSD) on the course of multiple sclerosis (MS). Objectives: To explore the impact of pre-existing PTSD on MS relapses, magnetic resonance imaging (MRI) activity, and disability in a large population-based cohort. Methods: Military Veterans with MS and PTSD prior to symptom onset (MSPTSD, n = 96) were identified using the Department of Veterans Affairs MS databases. MSPTSD cases were matched to MS controls without PTSD ( n = 95). Number of relapses, number of new T2 lesions and new gadolinium lesions on brain MRI, and neurological disability were abstracted between 2015 and 2019. Results: The mean annualized relapse rate was greater in the MSPTSD group versus controls (0.23 vs 0.06, respectively; p < 0.05), as was the annualized mean number of new T2 and gadolinium-enhancing lesions on brain MRI (0.52 vs 0.16 and 0.29 vs 0.08, respectively; p < 0.05). Disability accrual (time to Disability Status Scale 6.0) was more rapid (23.7 vs 29.5 years, p < 0.05) in relapsing MS patients with PTSD. Conclusion: Patients with MSPTSD have higher disease activity and reach disability endpoints more rapidly than controls. This is the first study to show PTSD as a potentially modifiable risk factor for MS relapses, MRI activity, and disability.

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“…A recent meta-analysis [ 13 ] showed that mental trauma in medical populations is significantly more relevant than previously thought. In particular, sepsis survivors, who are affected by invasive medical care, show high rates of clinically significant PTSD symptoms [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Trajectories of post-traumatic stress in sepsis survivors two years after ICU discharge: a secondary analysis of a randomized controlled trial

Schmidt,

Gensichen,

Schroevers

et al. 2024

Crit Care

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Background Post-traumatic stress has been identified as a frequent long-term complication in survivors of critical illnesses after sepsis. Little is known about long-term trajectories of post-traumatic stress and potentially modifiable risk factors following the ICU stay. Study objective was to explore and compare different clinical trajectories of post-traumatic stress symptoms in sepsis survivors up to two years after discharge from ICU. Methods Data on post-traumatic stress symptoms by means of the Post-traumatic Symptom Scale (PTSS-10) were collected in sepsis survivors at one, six, 12 and 24 months after discharge from ICU. Data on chronic psychiatric diagnoses prior ICU were derived from the primary care provider’s health records, and data on intensive care treatment from ICU documentation. Trajectories of post-traumatic symptoms were identified ex post, discriminating patterns of change and k-means clustering. Assignment to the trajectories was predicted in multinomial log-linear models. Results At 24 months, all follow-up measurements of the PTSS-10 were completed in N = 175 patients. Three clusters could be identified regarding clinical trajectories of PTSS levels: stable low symptoms (N = 104 patients [59%]), increasing symptoms (N = 45 patients [26%]), and recovering from symptoms (N = 26 patients [15%]). Patients with initially high post-traumatic symptoms were more likely to show a decrease (OR with 95% CI: 1.1 [1.05, 1.16]). Females (OR = 2.45 [1.11, 5.41]) and patients reporting early traumatic memories of the ICU (OR = 4.04 [1.63, 10]) were at higher risk for increasing PTSS levels. Conclusion Post-traumatic stress is a relevant long-term burden for sepsis patients after ICU stay. Identification of three different trajectories within two years after ICU discharge highlights the importance of long-term observation, as a quarter of patients reports few symptoms at discharge yet an increase in symptoms in the two years following. Regular screening of ICU survivors on post-traumatic stress should be considered even in patients with few symptoms and in particular in females and patients reporting traumatic memories of the ICU.

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Posttraumatic stress disorder prevalence in medical populations: A systematic review and meta-analysis

Cited by 16 publications

References 333 publications

Effect of a Low Concentration of Sevoflurane Combined With Propofol on Transcranial Electrical Stimulation Motor Evoked Potential: A Case Series

Effect of a Low Concentration of Sevoflurane Combined With Propofol on Transcranial Electrical Stimulation Motor Evoked Potential: A Case Series

Impact of comorbid post traumatic stress disorder on multiple sclerosis in military veterans: A population-based cohort study

Trajectories of post-traumatic stress in sepsis survivors two years after ICU discharge: a secondary analysis of a randomized controlled trial

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